Sentences with phrase «of gene regulation»

She leads a multidisciplinary team integrating computational and experimental approaches to develop an understanding of gene regulation in immune cells.

The quantum machine was also able to generate conclusions that were consistent with a biologist's current understanding of gene regulation.

But people often reject ideas which don't fit into the bacterial model of gene regulation, which is that genes are turned on and off by proteins binding to DNA.

The fact that RNA interference, another mode of gene regulation, is pervasive has only been realized in the past 10 years.

Recent discoveries have unveiled another means of gene regulation.

We want to understand this observation through the investigation of gene regulation in the context of the epigenetic landscape.

The objective of this meeting is to bring together leaders in the field to discuss the latest advances in stem cell biology with an emphasis on transcriptional and epigenetic mechanisms of gene regulation in pluripotent and neural stem cells.

Professor of Quantitative Biology of Gene Regulation at the University Medical Center Utrecht and Utrecht University since 2013

The second insight involved changes in the evolution of gene regulation: As social complexity increased, so did the speed of changes to parts of the genome involved in regulating gene activity, located in the promoters of the genes, the researchers report.

The modern study of gene regulation started in the 1950s, but researchers only started to unravel the complex array of histone modifications that fine - tune chromatin control of gene expression 20 years ago.

One aspect of gene regulation involves enzymes placing chemical tags or modifications on histone proteins — which control a cell's access to the DNA sequences that make up a gene.

The unexpected finding may also spark a new avenue of research on a type of gene regulation known as imprinting.

«We found that normal tissue affects the cancer that grows in that organ — in other words, the specific pattern of gene regulation in the normal breast affects breast cancer, the characteristics of the disease, and its clinical behavior,» said Dr. Avraham, a biologist and a researcher in the lab.

The researchers demonstrated the efficiency of the chip laboratory using a model system of gene regulation, the Lac - Operon.

This helps open the door to a functional dissection of the role of gene regulation during the evolution of modern humans.»

Her scientific expertise lies in understanding the epigenetic basis of gene regulation during embryonic development and disease ontology.

Professor of Quantitative Biology of Gene Regulations at the University Medical Center Utrecht and at Utrecht University

«New crystal structures reveal mysterious mechanism of gene regulation by the «magic spot».»

This silencing, or imprinting, mechanism has long been a central focus of gene regulation research, says Zhang, a geneticist at Boston Children's Hospital and Harvard Medical School.

This finding by Whitehead Institute scientists challenges current understandings of gene regulation via DNA methylation, from development through adulthood.

Epigenetic mechanisms give tortoiseshell cats their markings, but are also involved in our development in the womb and the day - to - day regulation of our genes

Weaving together perspectives from the fields of gene regulation and chromatin, Turner offers a concise discussion of the relations between the packing and organization of DNA within the cell nucleus and the regulation and expression of genes.

They believe that once quantum processors known as annealers accumulate qubits and have increased processing power, more complex cellular determinants of gene regulation that Rohs is currently studying could be encoded into new models that use quantum computers.

Epigenetic changes do not alter the structure of the DNA, but they do change the way the DNA is modified, which subsequently determines the potential of gene regulation.

MiRNAs are robust players of gene regulation in cells, and there are more than 1,300 different miRNAs at work in the brain.

A vital and ancient component of gene regulation, miRNA tunes the expression of as many as 30 - 60 % of mammalian protein - encoding genes, usually silencing them.

The findings from both studies open up tremendous possibilities for combatting cancer while simultaneously expanding our knowledge of gene regulation at a molecular level.

The publication of the latest Canine genome build and annotation, CanFam3.1 provides an opportunity to enhance our understanding of gene regulation across tissues in the dog model system.

We had suspected that the Mycoplasma genome might have a similar overall organisation to other bacteria, but we were completely surprised to find that it was also organised into domains, which can be considered as regulatory units of chromatin organisation and that we had identified a previously unknown layer of gene regulation.

Indeed, to get the full picture of gene regulation we need to look at the three - dimensional organisation of the chromatin that also coordinates gene activity.»

«The knowledge gained will help us understand many human disorders caused by malfunctions of gene regulation, a major goal of the NIH and of our new Institute for Genomics and Systems Biology in Chicago» White said.

Moreover, we observed that developmental genes associated with mm10 DNA loss hotspots were in genomic regions enriched for conserved elements that likely contribute to conservation of gene regulation [72].

Liu's scientific research focuses on the functional genomics of human cancers, particularly breast cancer, uncovering new oncogenes, and deciphering on a genomic scale the dynamics of gene regulation that modulate cancer biology.

Alexander van Oudenaarden is group leader at the Hubrecht Institute and professor of quantitative biology of gene regulation at the University Medical Center Utrecht and Utrecht University.

Among the speakers is Barbara Stranger, PhD, assistant professor in the Section of Genetic Medicine at the University of Chicago, who will speak on the genomics of gene regulation and its impact on health and disease.

The San Diego Epigenome Center, headed by Bing Ren, Ph.D., Professor of Cellular and Molecular Medicine at the University of California, San Diego School of Medicine and head of the Laboratory of Gene Regulation at the Ludwig Institute for Cancer Research, is an integral part of the five - year, $ 190 million push to accelerate research into modifications that alter genetic behavior across the human genome.

Combined with the right computational approaches, scNMT - seq has the potential to reveal undiscovered mechanisms of gene regulation, both in development and disease.»

Dr Penso - Dolfin, added: «Our results represent a clear improvement in our knowledge of the dog genome, paving the way for further research on the evolution of gene regulation, and the contribution of microRNAs to pathological conditions.

Dubbed model - organism ENCODE (modENCODE), this new focus will apply innovative methods and technologies for the study of gene regulation to the smaller, and therefore more manageable, genomes of the fruit fly (Drosophila melanogaster) and the round worm (Caenorhabditis elegans).

Even so, Siepel thinks the finding supports the theory that increased biological complexity in vertebrates and insects derives mainly from elaborate forms of gene regulation.

It's interesting to think about the way in which cultural phenomena, which we used to think were things by themselves, can have this effect on how much messenger RNA is made, and therefore on many aspects of gene regulation.

RNA interference (RNAi) is a type of gene regulation that naturally occurs in eukaryotes.

Eukaryotic cells have a very sophisticated pattern of gene regulation, much more complicated than the comparable system in bacteria.

Now, a team of researchers at Johns Hopkins has discovered that non-CpG methylation occurs later and more dynamically in neurons than previously appreciated, and that it acts as a system of gene regulation, which can be independent of traditional CpG methylation.

The role of gene regulation in C. auris drug resistance mechanisms and host interactions — such as overexpression of ERG11 and other known fluconazole resistance genes — are currently unknown.

«What is important in our study is that we proved that there was a unique and consistent solution to the fitting problem, something that has never before been achieved for a realistic complex model of gene regulation,» stated Dr. Jaeger.

The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases.