Sentences with phrase «of gene regulators»

Freiburg researchers map out the atlas of gene regulators in human cardiac cells for the first time

I am particularly interested in the neuronal tissue and the analysis of gene regulators implicated in both differentiation and brain tumor development.

«Surprising role of gene regulator protein in development of skin tumors.»

Not exact matches

The field of cancer epigenetics was recently transformed by the finding that genes encoding for epigenetic regulators are among the most commonly mutated genes in human cancers.

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

The team found that humans are equipped with tiny differences in a particular regulator of gene activity, dubbed HARE5, that when introduced into a mouse embryo, led to a 12 % bigger brain than in the embryos treated with the HARE5 sequence from chimpanzees.

The KAP1 protein acts as a regulator for several other genes which allow the brain to grow healthily and develop several types of brain cell.

Molecular studies of gene expression during long - lasting synaptic plasticity related to memory storage initially focused on the identification of positive regulators.

CLOCK is an acronym for «Circadian Locomotor Output Cycles Kaput,» because it is a central regulator of gene expression related to the body's circadian rhythm of sleeping and waking.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Rho, found in many bacteria, acts as a protein regulator of bacterial gene expression, determining which genes get turned on or off.

Federal regulators approved the first direct - to - consumer test for the BRCA genes, which increase the risk of breast and ovarian cancer, the agency announced on Tuesday.

«Now it's important to do the downstream work of validating these master regulators in the lab before we can test these genes in experimental models,» says Dr. Papapanou.

The drug turns off some of the regulators for the overactive tuberculosis gene network that was fighting off the bedaquiline.

In addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growth.

In mice, when the researchers inactivated the gene regulator GRHL2 in the fetal part of the placenta and in the embryo, the development of the labyrinth was severely disrupted.

Researchers at Columbia University College of Dental Medicine (CDM) Columbia University Medical Center (CUMC) have identified 41 master regulator genes that may cause gum disease, also known as periodontal disease.

He proved that the BCL6 gene was like an on and off switch, or master regulator, that triggered the production of Tfh cells, which in turn told the B cells to make more antibodies.

Regulators in the US could soon be asked to approve a human trial of gene therapy for cystic fibrosis that uses a hybrid of the HIV and Ebola viruses.

Igoshin said that when the researchers set out to find how sporulation decisions were timed to the cell cycle, several studies including prior work by team members, provided a significant clue: Under starvation conditions, the activity of the master regulator gene had been shown to spike once per cell cycle.

«Using yeast as a model organism, we studied the Tup1 protein, a negative regulator of gene expression,» says Biology Professor Emanuel Rosonina, adding, «This protein binds to some genes and blocks their expression, helping to ensure genes that shouldn't be turned on remain inactive.»

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

While miRNAs are generally negative regulators of gene expression in eukaryotes, they also negatively regulate larval development when honeybee larvae consume beebread / pollen and take up plant miRNAs.

They found evidence that the drug turns on the gene that produces the protein «FOXO,» a master regulator of stress resistance in many organisms that is often central in longevity studies.

For the first time, a research team led by Dr. Ralf Gilsbach and Prof. Dr. Lutz Hein from the Institute of Experimental and Clinical Pharmacology and Toxicology at the University of Freiburg have mapped out the gene regulators in the DNA of human cardiac muscle cells.

Sifting through this mountain of data, the scientists found three key genes that were altered by the NOTCH1 mutation and also acted as master regulators, turning off the critical pathways that normally prevent inflammation and calcification.

The Eischen group focused on the role of long non-coding RNAs (lncRNAs), which have emerged as key regulators of genes.

The study suggests that a less common version of the BDNF gene may predispose people to obesity by producing lower levels of BDNF protein, a regulator of appetite, in the brain.

Akassoglou and her colleagues thought they had a good candidate in the gene for the p75 neurotrophin receptor (p75NTR), a regulator of cell death in the brain that also switches on soon after liver injuries.

Using sophisticated genetic sequencing technology, King and Yin identified a common set of genes that are controlled by a shared network of genetic regulators known as microRNAs.

This pharyngeal gene cluster contains six genes ordered in a common pattern in all deuterostomes and includes the genes for four proteins that are critical transcriptional regulators that control activation of numerous other genes.

The researchers found that mutations to a gene called ATF6, a key regulator of the unfolded protein response, can lead to achromatopsia, a hereditary visual disorder characterized by color blindness, decreased vision, light sensitivity, and uncontrolled eye movement in children.

«The most intriguing of these genes is FGFRL1, which has a cluster of amino acid substitutions unique to giraffe that are located in the part of the protein that binds fibroblast growth factors — a family of regulators involved in regulating many processes including embryo development,» Cavener said.

«While many genes have been identified as genetic regulators of sleep or metabolic state, mounting evidence from our study indicates that translin functions as a unique integrator of these processes,» said Kazuma Murakami, co-first author and a Ph.D. student in the FAU / Max Planck Florida Institute Integrative Biology and Neuroscience (IBAN) program.

The MECP2 gene encodes methyl - CpG - binding protein - 2 (MeCP2), a transcriptional regulator of many genes including brain - derived neurotrophic factor (BDNF).

In the past five years, European regulators have approved two gene therapies - the first of their kind in the world, outside China - but only three patients have so far been treated commercially.

After decades of development, regulators have recommended approval for the first commercial gene therapy in Europe and the US.

In 2008, Dr. Côté's team explained the role of the DOCK1 and DOCK5 genes in the development of muscle tissue by showing that these two genes were critical regulators of the fusion process in mice.

It comprises nearly 35,000 genes, including the full set of oil biosynthesis genes and other transcriptional regulators highly expressed in the oil - rich palm fruit.

«People are more understanding of this research,» says Fan, who points to UK fertility regulators» approval in February of a proposal by developmental biologist Kathy Niakan to edit genes in healthy human embryos, at the Francis Crick Institute in London.

SP110 is a regulator of gene expression, mainly in immune cells.

Niakan's group focused on a gene called OCT4 (also known as POU5F1), a master regulator of gene activity, which is important in mouse embryo development.

When committee member Jennifer Kuzma, a policy analyst at North Carolina State University in Raleigh, asked what exactly represents a «different type of risk» from existing products, several regulators invoked another nascent technology, known as gene drive.

In 2003 Sinclair's lab published a paper in Nature that described the discovery of a gene that switched on in the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.»

Defects in this gene mean it can no longer fulfil its role as a regulator that helps purge the body of autoreactive immune cells termed T cells that can react against the body's own proteins, mistaking them for a foreign invader.

«This tells us that the NuRD complex is very influential — not only does it affect the activity of genes directly, it also controls other regulators of multiple genes,» Bonni said.

«The thing that really came home to us was that these ancestral Y chromosome genes — these real survivors of millions of years of evolution — are regulators of lots of different processes,» Bellott says.

The papers described the location of the newly named cystic fibrosis transmembrane regulator (CFTR) gene, its specific genetic code and the proposed structure and function of the protein it produced.

The molecules — YAP (Yes - associated protein) and TAZ (PDZ - binding motif)-- are critical regulators of downstream genes and proteins that are important for the expansion and specification of myelin - forming Schwann cells.

Mutation of a bacterial flagellar regulator gene can be compensated for by changes in a related nitrogen uptake regulator.