Sentences with phrase «of gene repression»

Gilbert, Luke A., et al. «Genome - scale CRISPR - mediated control of gene repression and activation.»

«How epigenetic memory is passed through generations: Sperm and eggs transmit memory of gene repression to embryos.»

Not exact matches

Epigenetics refers to biological processes — mostly biochemical modifications of the DNA and its associated proteins — that condition the expression or repression of genes.

They achieved this by transiently disturbing interactions between target genes and PcG proteins, which are complexes involved in the repression of several genes governing development.

Through temporary disruption of these interactions, the scientists were able to produce Drosophila epilines characterized by different levels of PcG - dependent gene repression or activation.

An example of epigenetic inheritance, this color diversity reflects varying degrees of heritable, but reversible, gene repression by PcG proteins.

Trithorax - like group complex containing KDM6A acts antagonistically to Polycomb - repressive complex 2 (PRC2) containing EZH2 in maintaining the dynamics of the repression and activation of gene expression through H3K27 methylation.

It had long been assumed that specific proteins bind to a metabolite and trigger expression or repression of genes.

This modification is usually associated with repression of genes in humans.

In addition, a number of key developmental regulators were expressed at higher levels in bsl1 - 1 mutants, including orthologs of classical genes from maize that specify AM identity and determinacy (e.g., bd1 [Chuck et al., 2002] and ramosa1 [Vollbrecht et al., 2005]-RRB-, that pattern lateral organ development (e.g., narrow sheath1 [Scanlon et al., 1996] and yabby10 [Juarez et al., 2004]-RRB-, and those implicated in carpel repression in maize tassels (e.g., grassy tillers1 [Whipple et al., 2011], tasselseed 1 [Acosta et al., 2009], and tasselseed 2 [Irish and Nelson, 1993]-RRB-(Table 2).

In the medium - term, CRISPR technology will be useful not for killing DNA but for real DNA editing: for gene replacement, or to modify specific amino acids and provide new functionalities to existent genes, and for transcriptional activation of repression of genes, modulating their expression levels.»

His group is are studying the mechanism of stable inherited epigenetic transcriptional repression by Polycomb - group (Pc - G) protein complexes, and the effects of deregulation of Pc - G genes on Homeobox gene expression, development, Cell cycle control and cancer formation.

Perhaps during normal inflorescence development, SMs poised to become bristles accumulate higher levels of BR, resulting in local increased cell division and expansion, loss of boundary identity genes, and repression of the SM identity program.

We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47 - base 3» untranslated region motif is implicated in this process.

As hemin levels are reduced, Bach1 is resynthesized and repression of HMOX1 and other genes is restored.

Now, researchers at the Hebrew University of Jerusalem and elsewhere have succeeded in graphically revealing this process, resolving a long - standing question as to whether the stem cells achieve their development through selective activation or selective repression of genes.

Bach1 has an endogenous ligand, heme, that inhibits Bach1 binding to ARE, thus allowing Nrf2 - mediated gene expression including that of heme - oxygenase - 1 (HMOX1), a well described target of Bach1 repression.

Similarly, HPP - 4382 was able to overcome repression of ARE - dependent gene expression by wild - type Bach1 protein but not mutant Bach1 protein.

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

In fact, CH methylation within a gene correlated more highly with repression than inaccessibility of DNA to transcription machinery (as measured by the ability of a transposase to grab onto genes).

It is often useful to deliver distinct functions to separate genomic loci, such as, activation of a set of genes and repression of another set of genes.

Although we could confirm a function of CHRAC / ACF in gene silencing, the extent of transcriptional repression scored in our tethering system was much stronger compared to the one in developing embryos.

We showed that Casilio modules are orthogonal, allowing simultaneous and independent activation and repression of different genes.

There it correlates with gene repression, but likely only in distinct subsets of cells within each organ, (see Schultz et al., 2015).