Sentences with phrase «of gene signatures»

Development of gene signatures to predict treatment efficacy in endocrine resistant ER + breast cancers

Those trials have since been halted, but the Institute of Medicine is setting up a panel to study clinical use of these gene signatures.

The prognostic role of a gene signature from tumorigenic breast - cancer cells.

Not exact matches

To answer these questions, Senior lecturer Xiao - Ru Wang and colleagues examined the signature of selection among members of a large gene family, the glutathione S - transferase (GST) in pine genome.

«Cancer cells disguise themselves by switching off genes, new research reveals: A genome - wide map of the genes switched off in aggressive tumors reveals a «signature».»

In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genome.

On its surface, the presence of Australasian genes might seem to indicate that people had sailed from that area across the Pacific Ocean to the Americas, but that genetic signature does not show up in people in the Pacific islands, which likely would have been along the route.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

By identifying gene expression signatures common to sight, touch and hearing, neuroscientists at the University of Geneva (UNIGE), Switzerland, discovered a sensory «lingua franca» which facilitates the brain's interpretation and integration of sensory input.

The authors defined the gene signature of the different regions surrounding the wound to uncover the gene expression signature of the cells that actively divide and those that migrate to repair the wound.

Surveillance organizations like the U.S. and world antidoping agencies «will look for those signatures and patterns that can be tied, with confidence, to the existence of a foreign gene,» Friedmann says.

The gene signature identified by Hancock and his colleagues relates to a special type of immune suppression called cellular reprogramming and suggests that treating inflammation in sepsis is a bad idea.

The researchers found that, beyond conferring resistance to proteasome inhibitors, the suppressed expression of proteasome subunits reflects a broad remodeling of the cell's gene signature.

Proponents of the gene protection initiative — a diverse coalition of environmental, animal - rights, and political groups that collected 111,000 signatures to bring the proposal to a vote — say their fight isn't over.

Today's findings augment recent research also published in Nature (Dec. 7, 2016) detailing the team's development of a «stemness biomarker» — a 17 - gene signature derived from leukemia stem cells that can predict at diagnosis which AML patients will respond to standard treatment.

Although a bad outcome was possible without the gene expression pattern, patients with the genetic signature were found to survive for less time than those who didn't have it, they wrote in the 9 December online edition of Nature Genetics.

Sure enough, salmon with a certain pattern of gene expression in their gill tissue were 13.5 times more likely to die than those that didn't carry the «you've not got long to live» signature, as co-author and University of British Columbia (U.B.C.) fish physiologist Tony Farrell puts it.

Scientists have identified unique genetic signatures strongly associated with a long and healthy life, findings that could help to further the understanding of how certain genes may offer protection from common age - related diseases like cancer, dementia and cardiovascular disease.

In addition to speeding up the development of brain plaques associated with Alzheimer's, a gene variant known as APOE4 also makes tau tangles — another signature of the disease — worse, researchers report online September 20 in Nature.

Rudich says that the study enabled the researchers to identify a «signature» for each source of bacteria based on the prevalence of antibiotic resistant genes, which revealed whether the genes were local or imported from distant deserts.

«Multiple genes, capable of enhancing T - cell responses, were found in the NF - κB signature.

«We're generating so much sequence data right now, from so many species, that it's relatively straightforward to look for signatures of selection in genes and to find good candidates for adaptations,» Montooth said.

Their findings indicate that intuition and signatures of selection in gene sequence may not be enough for scientists to conclusively solve the puzzles of molecular evolution.

More than two decades ago, in one of the first papers using gene sequences to find signatures of natural selection, scientists hypothesized that a molecular change in an enzyme gave the Drosophila melanogaster fruit fly species its superior ability to metabolize alcohol.

His troubles also led to an Institute of Medicine report that faulted Duke's oversight and found broad problems in the cancer field with using gene signatures and other biomarkers to guide treatment.

Surveillance organizations like the U.S. and world agencies «will look for those signatures and patterns that can be tied, with confidence, to the existence of a foreign gene,» Friedmann says.

Therefore, we sequenced the whole exomes of 98 HCCs from two hospitals in Taiwan and found that 78 % showed the distinctive mutational signature of AA exposure, accounting for most of the nonsilent mutations in known cancer driver genes.

Rapidly evolving genes are often a signature of a molecular arms race between organisms sharing an environment.

The researchers also analyzed an independent database of 536 glioblastoma samples and found the same signature of eight genes in those cases.

In a March 2009 study published in Genes and Immunity, researchers at the National Center for Computational Toxicology compared the genetic signatures of 16 people who experienced smallpox vaccine side effects, including fever, rashes and enlarged lymph nodes, to 45 people who did not.

One defends that these molecular signatures suggest a common evolutionary origin of skin appendages, whereas the other proposes that the same genes are re-used for developing different skin appendages.

Moreover, certain signature Mimi genes, such as those that code for the production of the soccer - ball shape of its capsid (an outer protein coat common to all viruses), have been conserved in viruses that infect organisms from all three of the domains, particularly in eukaryotes.

Greenberg's lab also found that the disruption of long gene expression appears to be a distinctive signature of Rett Syndrome and related disorders.

However, all regions of the human brain have molecular signatures very similar to those of our primate relatives, yet some regions contain distinctly human patterns of gene activity that mark the brain's evolution and may contribute to our cognitive abilities, a new Yale - led study has found.

The initial hint that KLF4 regulates mitochondrial biology came from genome - wide studies that revealed a strong signature for KLF4's control of mitochondrial genes.

When the team looked at what gene signatures the RORγt - dependent ILCs expressed, they found high expression of major histocompatibility complex class II (MHCII) protein, which some cells use to display foreign proteins to the immune system and directly interact with T cells.

Twisted signatures of GC - biased gene conversion embedded in an evolutionary stable karyotype

Epigenetic signatures in older cells — patterns of chemical marks on DNA that dictate what genes are expressed when — were reset to match younger signatures in the process.

The largest - ever study to sequence the whole genomes of breast cancers has uncovered five new genes associated with the disease and 13 new mutational signatures that influence tumour development.

Our next step is to start exploring our dataset in the search of such patterns of selection, for new signatures of gene flow among chimpanzee subspecies.»

But researchers are beginning to uncover a biological explanation for the problem: they have found a gene that may contribute to its development as well as a pathological signature of the disorder in the brain.

They found that 238 genes were significantly less active in the latter group — comprising a gene «signature» of metastatic myeloma.

Specifically, data from the Cancer Genome Atlas showed signatures of APOBEC3 - mediated mutations in the PIK3CA gene of about 40 percent of HPV - positive head and neck cancers, but only about 10 percent of HPV - negative head and neck cancers.

«If we knock out, one by one, a wide range of genes of known function, and analyze proteins, metabolites and lipids, using the technology that Josh's group has developed, the data provide a «signature» for what each protein is doing.

For example, the researchers were able to identify previously unknown gene expression differences between the neural stem cells that give rise to the brain's deep structures versus its neocortical surface, and to show that molecular signatures of different neural cell types arise much earlier in brain development than previously realized.

Lead researcher Dr Gabriella Ficz from QMUL's Barts Cancer Institute said: «It's surprising that cells from several healthy individuals are so permissive to gaining this epigenetic change and that one «hit» from an epigenetic editing tool is sufficient to set off this chain reaction of epigenetic inheritance and establish a cancer cell - like gene expression signature.»

Researchers from UCL (University College London) identified an epigenetic signature in the blood of women predisposed for breast cancer owing to an inherited genetic mutation of the BRCA1 gene.

Glioblastoma cells from patients that could be linked by the gene signature analysis with an immature origin generally showed a higher sensitivity to cancer drugs than glioblastoma cells that were associated with a more differentiated cell of origin.

So the shark - specific signature of adaptation found in the Bag1 gene may indicate an alternative, or modified role for this important gene — one that could alter its tendency to inhibit programmed cell death in sharks.

They were able to identify a «gene signature» of almost 200 genes.