Sentences with phrase «of gene transduction»

The use of viral vectors in research is beneficial for a number of reasons, including but not limited to: helping to get difficult - to - deliver DNA into mammalian cells, increasing the efficiency of gene transduction, allowing for control over which cells are infected through viral pseudotyping, and ease of vector cloning and modification.

Not exact matches

Mutations of the gene Lps selectively impede lipopolysaccharide (LPS) signal transduction in C3H / HeJ and C57BL / 10ScCr mice, rendering them resistant to endotoxin yet highly susceptible to Gram - negative infection.

FosB is a transcription factor in the brain which, together with other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines whether certain genes are activated or not.

However, their initial finding demonstrated that progenitor derived from iPSCs generated using lentiviral gene transduction led to the high incidence of highly aggressive tumors in immunodeficient mice after transplantation under the kidney capsule.

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

A well - known class of proteins may fill in the dotted lines that connect signal transduction pathways to the genes they regulate.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

The involvement of NF - κB in β - interferon gene regulation reveals its role as widely inducible mediator of signal transduction.

«Conventional techniques of producing transgenic animals, such as microinjection of genes into eggs and the retroviral transduction of genes into embryos, often produce many animals that are mosaic, which means they do not contain the foreign gene in all their cells.

Augmentation of adenovirus 5 vector - mediated gene transduction under physiological pH conditions by a chitosan / NaHCO3 solution.

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector.

The range of subjects includes, but is not limited to, immune cell development and senescence, signal transduction, gene regulation, innate and adaptive immunity, autoimmunity, infectious disease, allergy and asthma, transplantation, and tumor immunology.

Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].

His laboratory focuses on the roles of reversible protein modifications that are involved in modulating signal transduction, chromatin dynamics and gene activation.

Introducing new DNA often is achieved by viral transduction of target cells with a therapeutic transgene, through either a direct or cell - based gene therapy modality.

This induced pluripotent stem cell (iPSC) line was generated from IMR90 fetal lung fibroblasts by viral transduction of a combination of OCT4, SOX2, NANOG, and LIN28 genes.

The transduction of the genes into the primary cells requires the lentivirus and the transduction is much less efficient.

The AR is able to integrate into a composite signal transduction that acts as a conduit which will lead to a much bigger expression of certain genes.