This information may help to predict which other bacterial species might participate in this
form of gene transfer, and to identify just how widespread the phenomenon is.
More study is needed to pursue that possibility and to investigate the potential
use of this gene transfer technology to introduce other protective proteins into the brain.»
Dr. Verma, a professor in Salk's Laboratory of Genetics, has made outstanding advances in research ranging from cancer biology to development
of gene transfer technologies.
Failure to do this will render patients and families vulnerable, and risk bringing the wider field
of gene transfer for serious diseases into disrepute.»
Smith with graduate student M. Imran and collaborator D. Jones have constructed a simple model
of gene transfer in an immersed biofilm.
«Once we had discovered 120 new variants, we started testing them and, lo and behold, some were significantly better in
terms of gene transfer efficiency to specific tissues and organs,» Wilson says.
Kam Leong, a biomedical engineer at Columbia University in New York City whose team was the first to demonstrate success with this approach in mice, has even tried feeding the chitosan — DNA nanoparticles to dogs with haemophilia A. Leong found some
evidence of gene transfer and a reduction in inhibitors in the animals.
DNA analyses of the Oaxaca corn revealed several
signs of gene transfer from transgenic plants, including a gene of Bacillus thuringiensis (Bt), a bacterium that produces a toxin lethal to common pests.
Using computer models that calculate the
frequency of gene transfer between bacteria on the hyphae, the researchers came to the same result.
This is because the fungal highway enables pollutant - degrading bacteria to reach their food faster and, with the
help of gene transfer, they may even be upgraded along the way.
Strikingly the domestication of genes harboured by bracoviruses is not limited to» viral» genes, some of them originated from the wasp: in armyworm species, a
group of genes transferred was shown to be clearly more closely related to genes from hymenoptera, including the honey bee, rather than lepidoptera.
Dr. Sadelain is founding director of the Center for Cell Engineering and
head of the Gene Transfer and Gene Expression Laboratory at Memorial Sloan Kettering Cancer Center (MSKCC), where he holds the Stephen and Barbara Friedman Chair.
Specific activities include optimizing the conduct and
oversight of gene transfer research, updating and interpreting biosafety policies under the NIH Guidelines Involving Research with Recombinant and Synthetic Nucleic Acids, providing critical input on governmental policies regarding dual use research, the NIH Stem Cell Registry.
A Pilot Feasibility
Study of Gene Transfer For X-Linked Severe Combined Immunodeficiency (SCID) in Newly Diagnosed Infants Using a Self - Inactivating Lentiviral Vector To Transduce Autologous CD34 + Hematopoietic Cells