Sentences with phrase «of gene variations»

According to Hakonarson, two of the gene variations — acting alone — appear to increase one's odds of developing diabetes by 50 percent.

But over the past decade, researchers have identified hundreds of gene variations that seem to affect brain development in ways that increase the risk of autism.

The researchers plan to continue their research into the effects of the gene variation.

Dr. Innocentis NIH - funded research program is currently focused on the discovery of genomic determinants of efficacy and toxicity of cancer chemotherapy, integrating clinical genomic investigation with functional evaluation of gene variation.

Studies have shown that another possible consequence of this gene variation includes being sensitive to certain anesthetics such as nitrous oxide, which is commonly used for dental surgeries.

This is because atopic dermatitis, better known as eczema, is often a result of gene variation.

Not exact matches

The OAR proposal uses a variation of therapeutic cloning called altered nuclear transfer (ANT) in which the nucleus of a donor cell (a skin cell, for example), containing the 30,000 genes of the genetic code, is altered in such a way that it produces an epigenetic factor, a protein called nanog.

In the case of homosexuality we potentially are talking about randomly occurring variations of a a specific gene that would seem to occur with regularity.

The best model of what's happening is constrained randomness — random mutation constrained to a sort of space of all possible functioning variations of the gene.

An Israeli research group found that certain variations of the gene made people much more likely to affirm such statements as «I bubble with happiness» and «I am a cheerful optimist.»

In this paper, I tried to interpret evolution as a continually shifting balance, spatially and temporally, among what I called the pressures of mutation, selection, and migration on gene frequencies, in conjunction with the effects of random drift composed of random variations in these pressures and of local accidents of sampling.

This massive dataset is a powerful resource for understanding natural genetic variation in rice as well as for large - scale discovery of new genes associated with economically important traits.

Other research shows that ADHD children with a particular gene variation have thinner tissue in the area of the brain that's associated with attention.

Genetic variation can take the form of common base changes (polymorphisms) that alter gene function or rare base changes (mutations) that often have highly deleterious effects.

«Some people are protected from the effects of sleep deprivation by this particular gene variation but, for most of us, sleep loss does something to the brain that simply prevents us from switching gears when circumstances change.»

In the current study, Whitney, along with colleagues John Hinson, WSU professor of psychology, and Hans Van Dongen, director of the WSU Sleep and Performance Research Center at WSU Spokane, compared how people with different variations of the DRD2 gene performed on tasks designed to test both their ability to anticipate events and their cognitive flexibility in response to changing circumstances.

Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial - nuclear interactions alter the frequency of alternative forms of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population of the fish with mixed ancestry.

McCarroll found that patients who had certain variations of a gene called C4 were more likely to inherit the disease.

The sudden switch confounded most of the sleep - deprived participants, but those who had a particular variation of the DRD2 gene handled the switch as well as they did when well - rested.

Sleep - deprived people with two other variations of the gene tend to perform much more poorly on the same kinds of tasks, the researchers found.

There is no single mutation that causes Alzheimer's, says Wild, but we know of several gene variations that increase the risk of the disease.

Lacking money to outfit the new lab, Wang and Xin bought used equipment: a single channel DNA sequencer (bought and barely touched by a Harvard Medical School researcher); second - hand centrifuges and pipettes; a reconditioned CytoScan HD system that detects variations in the number of copies of a gene.

Based on the core principles of behavioral genetics, if genetics explain variations in distrust and trust behaviors, then identical twins should behave more similarly to each other than fraternal twins, since the genes of identical twins are shared, while the genes of fraternal twins are only imperfectly correlated, Reimann said.

Genetic variations most strongly associated with high scores were found near the GATA2 gene — involved in the development of inner ear hair cells and the inferior colliculus.

«Identifying which of these candidate genes actually causes variation in responses to cold snaps will give us the potential to understand whether evolution to climate change can occur in both wild and domesticated animals, allowing us to better predict which species or breeds will be «winners» and «losers» and to better mitigate the effects of anthropogenic climate change on a wide range of organisms from beneficial pollinators to invasive pests,» said Theodore Morgan an associate professor of evolutionary genetics in the Division of Biology at Kansas State University and senior author of the study.

For example, some variations of a gene are better suited for a dry climate, while other variations of that same gene are better suited for wetter environments.

They made these clones by a process called automatic parthenogenesis: The egg is formed normally (with half the species» usual number of chromosomes), then fertilized by the «polar body,» a cell that is created during oogenesis and contains the same gene copies as the egg, resulting in the shark having half the genetic variation of its mother.

Our genomes are strewn with millions of rare gene variations, the result of the very fast, very recent population growth of the human species.

More to the point, your health, your life span — and even some of your actions — may have more to do with the genetic variation in those microorganisms you host than they do with your own genes.

«It's sort of the tip of the iceberg,» says Uitterlinden, who led one of four groups that identified several variations in a gene called LIN28B that affect the timing of girls» first period, or menarche.

The study found that in the 18th and 19th centuries, about four to 18 per cent of the variation between individuals in lifespan, family size and ages at first and last birth was influenced by genes, while the rest of the variation was driven by differences in various aspects of their environment.

He had noted subtle variations between the resistance genes he pulled out of soil organisms and their doppelgängers in disease - causing bacteria.

To find other genes associated with these traits, researchers will need to scan the genomes of even more women and look for less common genetic variations, says Kári Stefánsson, CEO of deCODE Genetics in Reykjavik, Iceland.

So geneticists Stephen O'Rahilly and Sadaf Farooqi at the University of Cambridge, and colleagues, turned to a different kind of genetic variation, known as a deletion, in which entire genes are absent.

All four teams focused their hunts on gene variations found in at least 10 per cent of the population, while Stefánsson thinks that rarer variants may play a more significant role in menarche.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

«Within the context of our emerging appreciation of polygenic risk, where gene variations are implicated in several disorders, the new findings point to only partial overlap in the risk mechanisms for these two forms of bipolar disorder,» said Dr. Krystal.

Because of these variations, genes may be expressed differently from one individual to another.

The researchers discovered that patients who had certain genetic variations in interleukin genes had a better response to either surgery or chemotherapy, resulting in improvements in overall survival, disease - free survival and the amount of time until disease recurred.

The researchers found that adolescents who had a variation of another gene, which contributes to how quickly serotonin is recycled in the brain and which has been linked to hostile behavior in children, were more likely to exhibit signs of psychopathy.

Researchers at Moffitt Cancer Center hope to improve NSCLC patient survival with the results of a study that found that inherited genetic variations in interleukin genes are associated with improved patient survival and response to therapy.

This gene, which controls the amount of melanin pigment produced, accounts for about 74 percent of the total variation in people's eye color.

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

Next, he synthesised 50,000 DNA strands with sequences that almost matched parts of the 24 genes involved in lycopene production, but with a range of variations that he hoped would affect the amount of lycopene produced.

What turns out [is] that scientists are having [a] really, really hard time finding them, and what that tell [s] us is that there are these genes that influence intelligence but each particular gene is responsible for a tiny, tiny amount of variation — like a fraction of 1 percent.

Brin writes on his blog that the genome scan of his saliva from 23andMe told him he has a mutation on the LRRK2 gene, a variation called G2019S, which ups the risk for Parkinson's in some families.

One variation of the IRS1 gene caused lower fat in men.

In the current work, they used a new variation of the gene - editing system to repair the defect in both a mouse model and in human cells.

Scientists have found a variation of the miR - 182 gene in patients with primary open - angle glaucoma that results in this overexpression, said Dr. Yutao Liu, vision scientist and human geneticist in the Department of Cellular Biology and Anatomy at the Medical College of Georgia at Augusta University.

The number of copies of the resistance gene varies among cultivars; a new method, developed by University of Illinois researchers, is able to efficiently quantify this variation for the first time.