Sentences with phrase «of genes affected»

This approach and the threshold of 0.2 allows us to test our hypothesis that T cell DNA methylation is associated with aggression trajectory and to generate further hypotheses about the functions of genes affected by the associated methylation changes.

Many of the genes affected by the temperature treatment are also involved in important developmental processes (Long et al., 2012).

The study looked at genes and investigated how the loss of those genes affected the fly.

Gene ontology analysis of the genes affected across several tissues (Supplementary Fig. 8) shows enrichment for genes in the extracellular region and genes involved in nucleosome and chromatin assembly and in protein — DNA complexes.

We found that an unusually high number of genes affected by these DNA deletions / duplications are associated with the functioning of synaptic transmission between nerve cells.

In the associated paper, Vitkup, Iossifov and others use a novel form of analysis called NETBAG (network - based analysis of genetic associations) to identify «the large biological network of genes affected by rare de novo CNVs in autism.»

For example, 16 of the genes affected in the rats have analogs in humans, and those genes are linked to a predisposition for Alzheimer's, the study reports.

A single miRNA can ramp down expression of multiple genes — but the number of genes affected by known miRNAs hasn't been determined.

These researchers say that there are hundreds of genes affected by nurturance.

Some of these genes affect how you should train, some affect nutrition, and some affect both.

Additional research is also needed to determine how the C version of the gene affects the protein's function.

NMD also ensures that many mutations in our genes do not cause any disease symptoms — as long as the second copy of the gene affected is still intact and thus a correct version of the body plan is available.

The illness occurs when a DNA mutation within one of the genes affects the normal ocular development or induces photoreceptor — the cones and rods - degeneration.

One of those genes affects a hormone that raises blood sugar levels.

Not exact matches

In Kilgrave's case, for example, the gene therapy would need to be done extensively until all of his millions of affected cells were treated, something that's quite unlikely.

It probably sounds crazy, but it seems like there are a lot of possibilities of affecting factors with these gene traits.

But what's really significant in the research is the identification of which genes are selectively affected by consumption of dietary fat or by capsaicin.

Moshe Szyf, a molecular biologist at McGill University, discusses the way parental licking and grooming affects the expression of certain genes in rat pups.

Neuroscientists have over the past decade uncovered evidence, both in rodent and human studies, that parental caregiving, especially in moments of stress, affects children's development not only on the level of hormones and brain chemicals, but even more deeply, on the level of gene expression.

The evidence for epigenetic effects on emotion regulation is quite solid: Early caregiving experiences can affect the expression of the genes that regulate a baby's stress and they can shape how the endocrine system will mobilize to stress.

The Harvard School of Public Health reports that both a baby's genes and her environment can affect whether she will gain too much weight.

According to a 2006 article published in the «American Journal of Human Genetics,» mutations and genes can affect tooth development.

They examined whether there were differences in the composition of the breast milks» microRNAs, snippets of RNA that affect gene expression and can be passed to the infant.

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

It may be that those 37 different genes could affect the personality of the resulting child.

When looking into mechanisms that might affect the levels of SMN protein in neurons, the researchers scanned a genomic database called the UCSC Genome Browser and identified two genetic sequences that matched the opposite DNA strand of the SMN gene.

But over the past decade, researchers have identified hundreds of gene variations that seem to affect brain development in ways that increase the risk of autism.

The most common form of SMA is caused by mutation of the SMN gene, and manifests over a wide range of severity affecting infants through adults.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

Before this can happen though, Teixeira said that his team will first have to determine whether the Stk11 gene or the other genes and proteins it controls are similarly affected in the human form of BPH.

Because this imprinting affects hundreds of genes that are non-coding, including microRNAs and non-coding RNAs, it's a very interesting fine - tuning mechanism for the dosage of gene expression in the brain and elsewhere in the body.»

These are small molecules that can affect the way genes work, and the types of microRNA in our blood are known to vary according to age.

The handful of cases that still occur are most likely to affect non-Jews, families carrying mutations other than the distinctly Ashkenazi variants of the Tay - Sachs gene.

Additionally, the agency would continue efforts to advance precision medicine and cancer genomics in support of the Million Veteran Program (MVP), which aims to collect blood samples and health information from one million veteran volunteers to study how genes affect health.

«Over 40 % of prostate cancers lose PTEN and some lose both PTEN and another tumour suppressor gene, INPP4B, but we didn't previously have a clear picture of how this affects tumour growth,» says IMED Biotech Unit scientist Sabina Cosulich, at AstraZeneca.

The goal of early SMA drug discovery programs has been to identify small molecules that induce the SMN gene to produce sufficient levels of protein to improve motor neuron functioning in affected patients.

GWAS identify regions of the genome that can contain hundreds of genes potentially affected by a mutation.

Examples of gene networks in the hippocampus affected by brain trauma.

Standard approaches also struggle to find combinations of multiple genes that affect disease risk in complex ways (known as genetic interactions).

Because of either a genetic mutation or environmental factors that affect how the gene directs the protein's development, some people's oxytocin receptors may be folded up in ways that prevent them from binding well to the hormone.

The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

«It's sort of the tip of the iceberg,» says Uitterlinden, who led one of four groups that identified several variations in a gene called LIN28B that affect the timing of girls» first period, or menarche.

Now everything we do — everything we eat or smoke — can affect our gene expression and that of future generations.

Analysis of affected genes revealed possible functional effects from 532 of the mutations.

More and more, researchers are finding that an extra bit of a vitamin, a brief exposure to a toxin, even an added dose of mothering can tweak the epigenome — and thereby alter the software of our genes — in ways that affect an individual's body and brain for life.

Using a novel form of gene therapy, scientists from Harvard Medical School and the Massachusetts General Hospital have managed to restore partial hearing and balance in mice born with a genetic condition that affects both.

It involves the addition of a methyl group to DNA that changes the way genes are transcribed and affects gene expression.

Specific genes affect the risk of leprosy, says Amos, which may drown out the subtler effects of relatedness.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

Researchers then tested cell cultures and mouse models by using a gene editing process called CRISPR - Cas9 to demonstrate how the presence or absence of myomaker and myomerger — both individually and in unison — affect cell fusion and muscle formation.