Sentences with phrase «of genes associated with disease»

-- 90 percent of genes associated with disease are identical in the human and the mouse, supporting the use of mice as model organisms.

These products are designed to alter the expression of target genes in the body, suppressing expression of genes associated with disease, or restoring expression of genes required for health.

In 2015, the viral «Ice Bucket Challenge» helped fund groundbreaking research that led to the discovery of a gene associated with the disease.

Not exact matches

Collaboration based on new findings from the Regeneron Genetics Center ® showing variant in HSD17B13 gene is associated with reduced risk of chronic liver diseases

One - third of yeast genes have counterparts in the human genome, many of which are associated with diseases, such as cancer.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

Interestingly, as many as nine of the genes have been previously associated with some vascular disease and four more are known to be involved in the regulation of vascular tone, supporting the importance of blood vessels in migraine attacks.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

To find out, the researchers injected a cloned telomerase gene into cultured cells from retina, skin, and blood vessels, all of which are associated with degenerative, aging - related diseases.

Cases associated with changes in each of the four genes were different from each other in terms of symptoms, intelligence level and other disease features.

Meanwhile, the gene - rich X is the most intensely studied of the 23 chromosomes, largely because of its role in rendering men vulnerable to an estimated 300 genetic diseases and disorders associated with those mutations — from color blindness to muscular dystrophy to more than 200 brain disorders.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

An estimated 40 percent of the population has the primary gene variant associated with celiac disease, but only 1 percent of people with these genes go on to develop intestinal inflammation and damage — the hallmarks of the disease — after ingesting gluten.

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

Certain gene variants are associated with an increased risk of disease, but MS is rarely directly inherited.

Although there are several ways to remove RB from the cellular machinery, the group found that complete loss, rather than inactivation, of the RB gene was associated with changes in gene - networks closely linked to aggressive disease.

This breakthrough discovery was one of the first successful attempts to identify a gene associated with a disease.

Scientists have identified unique genetic signatures strongly associated with a long and healthy life, findings that could help to further the understanding of how certain genes may offer protection from common age - related diseases like cancer, dementia and cardiovascular disease.

In addition to speeding up the development of brain plaques associated with Alzheimer's, a gene variant known as APOE4 also makes tau tangles — another signature of the disease — worse, researchers report online September 20 in Nature.

«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.

«With more than 1.7 million people dying globally from TB each year and the rise of strains that are resistant to drug treatment, we need a better way to prevent this disease,» said the study's principal investigator Louis Picker, M.D., who is the associate director of the OHSU Vaccine and Gene Therapy Institute and a professor of pathology, molecular microbiology, and immunology in the OHSU School of Medicine.

Although that marker, called IL21, had not previously been associated with autoimmune diseases, the gene that produces it sits right in the stretch of DNA known to make these mice vulnerable to diabetes, suggesting that IL21 might make a drug target, says Sarvetnick.Furthermore, by giving the animals a shot of dead bacteria — similar to an immunization in humans — when they were newborns, Sarvetnick and her colleagues prevented a surfeit of CD4 + and CD8 + cells.

In theory, this could allow researchers to, say, cripple or replace many parts of genes associated with human disease that CRISPR currently can not touch.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

Some genes are indeed associated with the presence of specific viruses that can cause the disease.

Capra and colleagues examined DNA and electronic health records from more than 28,000 people of European descent to determine whether genes from extinct ancestors were associated with diseases.

Their findings, which appear in the August 2016 issue of the Journal of the American Chemical Society underscore the importance of looking at genes and proteins not classically associated with Alzheimer's to make progress in understanding the disease.

Those who also carried the apoE4 gene — already associated with accelerated development of Alzheimer's — were likely to show signs of the disease at even younger ages.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

A follow - up study of 96 other patients with Alzheimer's disease confirmed that this HLA variant is associated with earlier onset of Alzheimer's, although Payami cautions that another gene very close to HLA - A2, and not HLA - A2 itself, could be at fault.

The new finding is the latest evidence supporting a growing precision medicine model of psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.

It is also known that zebrafish and humans have very similar genes, and these similarities extend to more than 80 % of the genes associated with human disease.

However, most disease genes discovered in the past decade indicate only an elevated risk, not a certainty, of developing the disorders with which they are associated, including cancer, diabetes, and heart disease.

Harris cited other examples of concern — a review of 100 studies in the field of psychology in which the findings in only about a third of the studies were reproducible; an effort by scientists at Bayer, another large drug company, that managed to reproduce the findings of only one - quarter of the studies under review; a just - published review of 25 historical candidate genes for schizophrenia which found no evidence that the candidate genes are more associated with the disease than other genes.

The new study suggests that even rare mutations that disable both copies of a gene, which scientists thought would be associated with diseases, aren't necessarily a problem.

A series of genes is now associated with Parkinson's disease.

Silencing of one of the «cell death» genes may be the first step in finding treatments to help woman delay menopause or avoid the health problems — osteoporosis, heart disease — associated with the cessation of estrogen production.

To help in his hunt for disease genes, Pe'er founded The Ashkenazi Genome Consortium (TAGC) in September 2011 with Todd Lencz, an investigator at The Feinstein Institute for Medical Research, director of the Laboratory of Analytic Genomics at the Zucker Hillside Hospital, and associate professor of molecular medicine and psychiatry at the Hofstra North Shore - LIJ School of Medicine.

Researchers studying two generations of a family affected by pediatric acute lymphoblastic leukemia (ALL) have identified an inherited variation in the ETV6 gene that is associated with an increased risk of developing the disease.

The largest - ever study to sequence the whole genomes of breast cancers has uncovered five new genes associated with the disease and 13 new mutational signatures that influence tumour development.

Ataxin - 7 is one of several genes associated with neurodegenerative diseases, including Huntington's disease and other spinocerebellar ataxias.

«Any treatments that help these children will methuselah of hyperaging and genes very likely help millions of people with cardiovascular disease and potentially other problems associated with aging,» she says.

This past September, a pair of research teams announced that they had identified three new genes associated with Alzheimer's disease.

A decade ago, they also identified a relationship between ALS and excess iron accumulation when they found that 30 percent of ALS patients in their clinic carried a variant of a gene known as HFE that is associated with iron overload disease.

Researchers led by Baylor College of Medicine have developed a new computational method to study the function of disease - causing genes, starting with an important new discovery about a gene associated with malaria — one of the biggest global health burdens.

Many companies advertise a laundry list of disease risks associated with your genes.

Indeed, nine of the 16 most distinctive genes are ones that in humans are associated with heart disease, Willerslev says.

«As the gene loci that had previously been associated with DLB were also implicated in Alzheimer's and Parkinson's, it was unclear if DLB's genetic roots were simply a combination of the other two diseases.

Interestingly, the team also found the spread of two gene variants associated with celiac disease.