Sentences with phrase «of genes switching»

«Cancer cells disguise themselves by switching off genes, new research reveals: A genome - wide map of the genes switched off in aggressive tumors reveals a «signature».»

The same seems to be true of the gene switches that turn on cancer cells.

Epigenetic therapies are thought to work in two ways to fix these errors in cancer cells — by correcting the «position» of the gene switches and by making the cell appear as though it's infected by a virus, triggering the immune system.

Not exact matches

Our gee show that micro changes in our epigenetics can turn on and off genes or have them exhibit themselves in different ways and with enough flipping of the micro switches you can get some pretty impressive macro changes in relatively short periods of time.

Rather than jamming the operon, the relevant genes were copied and placed within the reach of a genetic switch which turned them on.

Davies and Lineweaver suggest that genes active in embryogenesis and switched off later may be reactivated because of damage, causing the accelerated cell division of these rogue cancer cells.

Vocabularies proliferate as repressor genes, corepressors and aporepressors, modifier and switch genes, operator genes that activate other genes, cistrons and operons that constitute subsystems of interacting genes — even genes that regulate the rate of mutation in other genes — are invoked.

Experiments proved that Heat Shock Factor 1 (HSF1), a sort of protective switch against some types of cellular stress, could bind to the TTR gene's promoter (a segment of DNA near the TTR gene).

Gene, Gene the Coke Machine (that's Coke as in soda pop) is the team's moniker for the 6» 3», 280 - pound Chilton, who's being switched from tackle to center, where he'll anchor an offensive line that lost four of five starters, not counting both tight ends.

Using gene - sequencing technology, researchers established that the precise segment of the pup's DNA «switched on» by the act of grooming was the part that controlled the future function of the hippocampus, which processes stress hormones.

They discovered an orchestrated switching on and off of various genes as the mammary gland transitions from secreting small amounts of immunity - boosting colostrum in the first days after giving birth to the copious production of milk in mature lactation.

«Some people are protected from the effects of sleep deprivation by this particular gene variation but, for most of us, sleep loss does something to the brain that simply prevents us from switching gears when circumstances change.»

The sudden switch confounded most of the sleep - deprived participants, but those who had a particular variation of the DRD2 gene handled the switch as well as they did when well - rested.

Epigenetic tags help tell genes — stretches of DNA that act as biological instruction manuals — when to switch «on» and «off,» ultimately determining cell type and function.

Epigenetic processes are essentially switches that control a gene's potentially heritable levels of protein production but without involving changes to underlying structure of a gene's DNA.

In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genome.

Nathaniel Hoyle of the MRC Laboratory of Molecular Biology in Cambridge, UK, and his colleagues have discovered that genes in a type of skin cell switch on and off during day - night cycles.

Clones may be the way to go when nutrients and water are plentiful, but when the going gets tough, plants often switch to sex, which lets them try out different, possibly advantageous arrangements of genes.

This finding came as a surprise since it was assumed that as a consequence of the evolutionary divergence between human and other animal viruses, the genes that code for LANA could not be switched.

«It's a master switch that turns on hundreds of genes necessary to build the powerhouse machinery of the cell.»

The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.

Keith Pardee, also at the Wyss Institute, made synthetic chunks of DNA containing gene switches called toeholds.

This action can result in the activation of genes that had been switched off, and could be the cause of the recovery of synaptic strength.

The key insight for building such drugs came to Tim Tully, founder and chief science officer of Helicon, when his team at Cold Spring Harbor Laboratory on Long Island stumbled upon the molecular switch: a gene called CREB, which is involved in converting short - term memories into long - term ones.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

Using this technique, the team first identified millions of short fragments of RNA located at the start of genes — at the so - called «5 [prime]» end, where genes are switched on.

Over time, some of these developed the ability to build proteins and switched to double - stranded DNA to carry their genes.

These epigenetic switches and markers in turn help switch on or off the expression of particular genes.

Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.

But after months of painstaking research they had at last succeeded in switching off the gene and getting rid of the glow.

She also sought out genes that controlled the switch for maturation of T helper cells, maintaining just the right balance of T helpers — between Th1 cells that suppress allergic responses and Th2 cells that trigger them.

They noted that Tregs generally had high levels of a protein called Helios, a transcription factor that helps switch genes on and off.

The only trouble was that the Nasmyth lab was devoted entirely to the study of the HO gene (involved in mating - type switching) in the budding yeast Saccharomyces cerevisiae.

«The IMM teams showed clearly that the gene was switched on only in hypoxic regions,» says Sue Kingsman, the research director of Oxford BioMedica.

But pairs of so - called imprinted genes have just one copy «switched on».

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

«By switching certain genes on and off, prions could help bacteria survive environmental stresses rendering them less vulnerable to drugs, chemicals and other environmental assaults,» says investigator Ann Hochschild, professor of microbiology and immunobiology at HMS.

The system has the potential to add, change or switch off thousands of genes at a time — Church calls this «multiplexing» — and it can generate billions of new strains in days.

The new gene permanently switched on a set of genes normally affected by insulin and involved in the immune system.

Harris and Peter Ratcliffe, also at the IMM, discovered the genetic switches, which they call «hypoxia - responsive elements» (HREs), in segments of DNA known as regulatory genes.

To determine the effect of mutations that reduce TET2 function in abnormal stem cells, the research team genetically engineered mice such that the scientists could switch the TET2 gene on or off.

Affected family members, the group found, had inherited one or two defective copies of ZIC3, a previously unknown gene that appears to code for a transcription factor — a protein that switches other genes on or off.

To create them, the skin cells need to be reprogrammed to an embryonic state by exposing them to extra amounts of four critical gene switches.

Instead, the genes have been switched off by the addition of chemical tags called methyl groups.

This test determined that only a few genes switched off when signaling was blocked — and one of them was the gene known to code for MHCI.

Issued last March to researchers at a little - known cotton seed company called Delta & Pine Land (D&PL) and the U.S. Department of Agriculture, the patent covers a technique for transferring three genes along with their genetic on switches into the seeds of genetically improved plants.

By tweaking different fly genes and counting how many neuron types were produced as the flies matured, the team identified a network of five genes that work together like coordinated control switches to guide the precursor cells» transformation to mature neurons.

All cells contain the same DNA, but individual genes in any cell can be switched on or off by the addition or subtraction of a methyl group — a carbon atom bound to three hydrogen atoms.

Gene switches have been identified that work in specific brain areas, potentially enabling targeted treatment of unhealthy cells.

For instance, alterations to these chemical switches can change the architecture of the heterochromatin, causing genes to be expressed or silenced.