Sentences with phrase «of glioblastoma tumors»

«Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells.»

Neuroscientist Duane Mitchell of Duke University Medical Center and his colleagues confirmed in 2007 that CMV is active in at least 90 percent of glioblastoma tumors.

Biopsied samples of glioblastoma tumors contain high level of STK17A.

Analysis of glioblastoma tumor coverage by oncolytic virus - loaded neural stem cells using MRI - based tracking and histological reconstruction.

Regulation of Glioblastoma Tumor - Propagating Cells by the Integrin Partner Tetraspanin CD151.

Not exact matches

Novocure's main focus to date has been treating glioblastoma, or GBM, a type of tumor that affects the brain.

Glioblastoma multiforme is the most common and deadliest of the glial tumors because the cells reproduce so rapidly.

In 2009 he had been diagnosed with a type of rapidly growing brain tumor called a high - grade astrocytoma that, despite aggressive treatment, eventually evolved into a glioblastoma — the highly malignant brain tumor that also took the lives of Vice President Joe Biden's son, Beau, in 2015 and former Sen. Ted Kennedy in 2009.

Glioblastoma remains one of the most difficult types of brain tumors to treat successfully.

Sen. John McCain of Arizona last week revealed he is battling glioblastoma, the most common and aggressive type of malignant brain tumor in adults.

The scientists also tested the therapy on tumors taken from two patients who had not responded to conventional therapy for their glioblastoma, a deadly form of brain cancer.

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

Now, a high - fat, low - carbohydrate version of the ketogenic diet has been shown to slow glioblastoma tumors by cutting back on the energy supply they need to thrive, said Brent Reynolds, Ph.D., a professor in the Lillian S. Wells Department of Neurosurgery.

Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor.

Although there have been great advances made in the treatment of leukemias and other cancers, little is known about how Glioblastomas are formed and how these tumors infiltrate the brain tissue.

«We know that 70 - 75 percent of glioblastoma patients undergo surgery for tumor debulking, and we have previously shown that MSCs encapsulated in biocompatible gels can be used as therapeutic agents in a mouse model that mimics this debulking,» he continued.

«Our study identified miR - 182 as a glioblastoma tumor suppressor that reduces the expression of several oncogenes that promote cancer development,» said senior author of the study Alexander Stegh, an assistant professor in the Ken and Ruth Davee department of neurology and of medicine at Northwestern University Feinberg School of Medicine.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

Several studies have used cell - surface markers — proteins found on the outer membranes of tumor cells — to identify glioblastoma stem cells; but the specific markers used have been controversial and can not reflect molecular processes going on within tumor cells.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

Glioblastoma is one of the most common types of malignant brain tumors in adults.

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

Testing each of these factors for their ability to return differentiated tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.

Identifying the drivers of these different cellular states in glioblastoma stem cells could offer us the best opportunity for treating what remains an extremely difficult - to - treat tumor.»

While there have been improvements in the current standard treatments, patients with glioblastoma (GBM), the most common and aggressive form of brain tumor, still suffer from a median survival rate of only 14.6 months and 5 - year overall survival rates of less than 10 %.

A glioblastoma tumor requires large amounts of energy as it grows, and the dietary intervention works by drastically limiting the tumor's supply of glucose, Reynolds said.

And a small number of glioblastoma patients do not have CMV in their tumors.

In 2002 scientists showed that cytomegalovirus, or CMV, was active in the brain tumors but not the surrounding healthy tissue of all 27 patients they tested who had glioblastoma multiforme.

Baliga's group is also mapping networks in patients with glioblastoma, a particularly deadly type of brain tumor.

Glioblastoma accounts for about 15 percent of all brain tumors, is resistant to current therapies and has a survival as short as 15 months after diagnosis.

From tissue and cell samples from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the lab.

Little is known, however, about the metabolic pathways that drive the growth of individual glioblastoma subtypes — knowledge that is crucial for developing novel and effective targeted therapies that might improve treatment for these lethal tumors.

Glioblastoma is the most aggressive type of tumor that originates in the brain and with no curative treatments currently available, the average survival time for patients ranges from 15 to 18 months.

Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothingGlioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothingglioblastomas but which, lacking tumor stem cells, were nothing of the kind.

In a study published in the Journal of NeuroOncology, TGen researchers report that PPF works to limit the spread of glioblastoma multiforme, or GBM — the most common primary tumor of the brain and central nervous system — by targeting a protein called TROY.

«We've had luck with other types of cancer in removing the brakes on the immune system to allow it to fight the tumors, but this has not been the case with glioblastoma,» said study author Anhua Wu, MD, PhD, of the First Hospital of China Medical University in Shenyang, China.

«Drug could limit spread of deadly brain tumors: Study shows PPF could help treat glioblastomas by sensitizing tumors to chemotherapy, radiation treatments.»

A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

However, because of the aggressive way glioblastomas invade surrounding brain tissue, it is impossible to remove all parts of the tumors, and the cancer eventually returns and spreads.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

Researchers have identified a group of immune system genes that may play a role in how long people can live after developing a common type of brain cancer called glioblastoma multiforme, a tumor of the glial cells in the brain.

In a model of glioblastoma, a brain cancer that does not metastasize outside of the brain, they could readily see that the length of circulating tumor DNA was smaller than healthy DNA by 20 - 50 base pairs.

Of the 297, 127 people had glioblastoma and 170 had a lower grade glioma, which is also a tumor of glial cells, but less aggressive than glioblastomOf the 297, 127 people had glioblastoma and 170 had a lower grade glioma, which is also a tumor of glial cells, but less aggressive than glioblastomof glial cells, but less aggressive than glioblastoma.

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

«This finding suggests a novel therapeutic target to decrease invasion of tumor cells in patients and may also provide a novel biomarker that could help predict survival of patients with glioblastoma,» explained Israel.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

These findings provide further evidence of ONC201 as an inhibitor of cancer stem cells and support ongoing clinical trials in prostate cancer and glioblastoma that have shown evidence of tumor shrinkage.

The loss of the tumor suppressor gene PTEN has been linked to tumor growth and chemotherapy resistance in the almost invariably lethal brain cancer glioblastoma multiforme (GBM).

The study — Genomic profiles of low - grade murine gliomas evolve during progression to glioblastoma — published April 7, shows how these tumors continue to rapidly evolve, becoming ever more genetically diverse, as they become malignant and progress.