Sentences with phrase «of glioma»

Now researchers at Uppsala University, together with American colleagues, have shown that one and the same cell of origin can give rise to different types of glioma.

«Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells.»

The team tested the approach in healthy rats as well as an animal model of glioma brain cancer.

There was, however, a possible increased risk of glioma for users with a high level of use (30 minutes a day or more)-- and this finding has prompted the World Health Organisation (WHO) to add mobile phones to their list of possible causes of cancer.

In this area of the genome the researchers then identified three genes as the most associated with the development of glioma in dogs.

Researchers developed models to examine the influence of driver mutations — mutations that promote cancer development — on the initiation and development of gliomas, and how tumor genomic profiles evolve as the cancer progresses.

Moreover, each subtype of glioma stem cells is driven by distinct transcriptional programs for growth and treatment resistance, and these different cell populations correspond to well - known morphological differences within the GBM itself.

Abstract SY28 - 04: Rational incorporation of novel agents into multimodality treatment of glioma and neuroblastoma

They identified a subpopulation of glioma stem cells, which, unlike most glioma cells, did not accumulate substantial amounts of fluorescent product during photodynamic detection.

Dr. Berens also is Director of the Cancer and Cell Biology Division and head of the Glioma Research Lab at TGen.

Glioblastomas make up 55 - 60 percent of gliomas, with lower - grade astrocytomas comprising 15 - 20 percent of cases, oligodendrocytes 12 - 20 percent and combination oligo - astrocytomas at 5 - 10 percent.

Through a variety of preclinical experiments, the team demonstrated that increasing the expression of miR - 184 slows the growth and invasive characteristics of glioma cells through direct regulation of SND1.

Small numbers of glioma stem - like cells, or GSCs, drive the tumorigenicity of GBM and thus are prime targets for possible treatments.

The researchers showed that it inhibited ALDH in yeast, reduced ALDH1 activity in cell - culture spheres of mesenchymal GSCs, inhibited proliferation of glioma spheres in cell culture, and inhibited xenograft growth of GBM in mouse brains.

They demonstrated that in the absence of SERT, antidepressants accumulate gradually in the plasma membrane microdomains of glioma cells.

Historically, the typical incidence of gliomas and schwannomas in normal rats has been about 2 per cent and 1 per cent, respectively.

We have for a long time been interested in finding out more about the origin of gliomas and how it is associated with the genetic alterations that cause the tumor,» says Lene Uhrbom, researcher at the Department of Immunology, Genetics and Pathology, who has led the study.

There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation.

The most common site of involvement of a glioma is the brain, but they can also affect the spinal cord, or any other part of the CNS, such as the optic nerves.

Dr. Sloan said that since a single tumor may contain different pools of glioma stem cells, combined targeting should be considered for the pathways and stem cells.

But the addition of rapamycin to immunotherapy even for a short while also allowed the rodents to develop tumor - specific memory CD8 + T cells that remember the specific «signature» of the glioma tumor cells and attacked them swiftly when a tumor was introduced into the brain again.

«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent on glucose metabolism in the absence of oxygen.

Gerard's view that cancer phenotype is of the utmost importance, is one that resonates with Dr Simona Parrinello, a cell biologist based at Imperial College's Hammersmith Campus who studies the mechanisms of invasion of glioma, a type of brain cancer.

They also identified the second recurrent mutation (Gly34Arg) in 14 % of the glioblastomas, but none of the gliomas, findings remarkably consistent with the GBM study.

The Glioma Cellular Genetics Resource will provide high quality well - characterised cellular models of glioma with matched normal stem cells, together with all the validated genome editing tools that the community needs.

Simona thinks that this cell biological approach could help make sense of the heterogeneity of gliomas and improve our understanding of invasion overall: «These are key questions — we need to know how invasion is driven as it could have profound implications for therapy».

U-M's internationally renowned Translational Neuro - Oncology Laboratory generates novel primary cell cultures from pediatric and adult glioma tissue samples to study mechanisms of glioma growth and targeted treatment response.

Syed P et al. (2016) Autoantibody Profiling of Glioma Serum Samples to Identify Biomarkers Using Human Proteome Arrays Sci Rep2015 Sep 15; 5:13895.

Man J, Shoemake S, Zhou W, Fang X, Wu Q, Rizzo A, Prayson R, Bao S, Rich JN, Yu JS, Sema3C Promotes The Survival and Tumorigenicity of Glioma Stem Cells Through Rac1 Activation.

Dr. Li's clinical research interest is in the area of glioma pathophysiology and ambulatory EEG.

Different types of glioma are usually diagnosed as separate diseases and have been considered to arise from different cell types in the brain.

In a paper published today in Cancer Research, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed.

Treatment of glioma has remained a challenge despite the options for surgical resection followed by chemotherapy and radiotherapy.

The authors concluded: «Overall, no increase in risk of glioma or meningioma [the two most common types of brain tumors] was observed with use of mobile phones.

Glioblastomas represent roughly 60 - 70 % of all gliomas, and for this type of glioma there is no curative treatment.

Although BRAF gene fusions were well known to be involved in PLGGs, the study team found important differences in a related gene, CRAF, in which mutations can also lead to this type of glioma.

There are different types of glioma, classified according to an established system based on which cell type the tumor arises from.

The activation of this signaling pathway progressively increased in different types of gliomas, with the highest activity seen in patients with glioblastoma, a particularly difficult - to - treat form of brain cancer that represents approximately 15 percent of all brain tumors.

Devised unique genetically engineered laboratory models of gliomas to identify cancer drivers and test potential therapies

Molecular testing: Some primary brain tumors, including some of the most common types of gliomas, are defined by their key molecular features resulting from tumor cell mutations.

We've linked up with UCL on this, and together have the patient numbers to increase the number and different subtypes and different types of glioma we can include in this open library.

They found striking recurrence of lysine - 27 mutations in H3F3A or the closely related gene HIST1H3B (which encodes H3.1) in 78 % of gliomas and 22 % of non-brainstem glioblastomas.

Now researchers at SciLifeLab have shown that one and the same cell of origin can give rise to different types of glioma.