Sentences with phrase «of glioma cells»

They demonstrated that in the absence of SERT, antidepressants accumulate gradually in the plasma membrane microdomains of glioma cells.

Through a variety of preclinical experiments, the team demonstrated that increasing the expression of miR - 184 slows the growth and invasive characteristics of glioma cells through direct regulation of SND1.

Research ROS accumulation and IGF - IR inhibition contribute to fenofibrate / PPARα - mediated inhibition of Glioma cell motility in vitro.

Not exact matches

A paper he published early this year in the Journal of Clinical Oncology describes a dendritic cell vaccine in advanced glioma, an aggressive form of brain cancer.

«Our study suggests that ALDH1A3 is a potentially functional biomarker for mesenchymal glioma stem cells, and that inhibiting that enzyme might offer a promising therapeutic approach for high - grade gliomas that have a mesenchymal signature,» says principal investigator Ichiro Nakano, MD, PhD, associate professor of neurosurgery at the OSUCCC — James.

And in May, a week after Massachusetts Sen. Edward Kennedy was diagnosed with a glioma, The EMR Policy Institute, a Marshfield, Vt. — based nonprofit organization that supports research on the effects of electromagnetic radiation, released a statement linking his tumor to heavy cell phone use.

«Overall, our data suggest that a novel signaling mechanism underlies the transformation of proneural glioma stem cells to mesenchymal - like cells and their maintenance as stem - like cells,» Nakano says.

There is plenty of anecdotal evidence out there claiming a link between cell phone use and cancer: Keith Black, chairman of neurosurgery at Cedars - Sinai Medical Center in Los Angeles, says that the brain cancer (malignant glioma) that killed O. J. Simpson's attorney, Johnnie Cochran, was the result of frequent cell phone use, based on the fact that the tumor developed on the side of the head against which he held his phone.

Inhibiting ALDH1A3 - mediated pathways slows the growth of mesenchymal glioma stem cells and might provide a promising therapeutic approach for glioblastomas with a mesenchymal signature.

Mesenchymal glioma stem cells show significantly higher radiation resistance and high expression of DNA - repair genes;

Now, Johns Hopkins researchers report they have used nanoparticles to successfully deliver a new therapy to glioma cells in the brains of rats, prolonging their lives.

Of the 297, 127 people had glioblastoma and 170 had a lower grade glioma, which is also a tumor of glial cells, but less aggressive than glioblastomOf the 297, 127 people had glioblastoma and 170 had a lower grade glioma, which is also a tumor of glial cells, but less aggressive than glioblastomof glial cells, but less aggressive than glioblastoma.

In a new study published in Scientific Reports, Tokyo Medical and Dental University (TMDU)- led researchers investigated photodynamic detection of cancer stem cells in a glioma cell line, a model of a highly aggressive type of brain cancer.

They identified a subpopulation of glioma stem cells, which, unlike most glioma cells, did not accumulate substantial amounts of fluorescent product during photodynamic detection.

Dr. Berens also is Director of the Cancer and Cell Biology Division and head of the Glioma Research Lab at TGen.

The results suggest the simultaneous activation of certain molecular pathways — actions among molecules in a cell that can lead to change — in particular the MAPK and PI3K cellular pathways, triggered tumor initiation and produced increasingly dense low - grade gliomas that quickly progressed to glioblastoma multiforme (GBM).

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

Small numbers of glioma stem - like cells, or GSCs, drive the tumorigenicity of GBM and thus are prime targets for possible treatments.

They then conducted biochemical analyses to identify neuroligin - 3, confirm that the protein could stimulate tumor growth in cultured samples of several kinds of human high - grade gliomas and study which signals the protein uses within glioma cells to promote their growth.

Gαs went from lipid rafts to nonraft regions of the plasma membrane in the glioma cells, which enhanced its signaling ability.

There are different types of glioma, classified according to an established system based on which cell type the tumor arises from.

«We showed that the probe is equally capable of detecting invasive cancer cells from all grades of invasive gliomas,» says Dr. Petrecca.

Dr. Sloan said that since a single tumor may contain different pools of glioma stem cells, combined targeting should be considered for the pathways and stem cells.

But the addition of rapamycin to immunotherapy even for a short while also allowed the rodents to develop tumor - specific memory CD8 + T cells that remember the specific «signature» of the glioma tumor cells and attacked them swiftly when a tumor was introduced into the brain again.

«Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells.»

«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent on glucose metabolism in the absence of oxygen.

«Inhibition of the EZH2 pathway slows growth of tumors in mouse brain derived from glioma stem cells from the enhancing margin of human tumors.

They will follow this approach to design a novel treatment plan by rationally combining gemcitabine with cell cycle checkpoint inhibitor, oxygen - enrich gas inhalation, and radiotherapy to significantly inhibit the growth of aggressive glioma.

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Brain Tumor, Pediatric High Grade Gliomas, Histones, Epigenome, Cancer Genomics, Giant Cell Tumors of the Bone, Animal Models

«This is exciting because it's the first animal model of pediatric high - grade gliomas, or malignant brain tumors,» says Maria Castro, Ph.D., senior author of the paper and a professor in the departments of Neurosurgery and Cell and Developmental Biology at U-M.

Reykjavik, ICELAND, 25 September 2011 — Scientists at deCODE Genetics and academic collaborators from Iceland, The Netherlands, Spain, Denmark, Germany, Sweden, the USA, the UK and Romania today report the discovery of a variant in the sequence of the human genome associated with risk of developing basal cell carcinoma of the skin (BCC), as well as prostate cancer and glioma, the most serious form of brain cancer.

Molecular testing: Some primary brain tumors, including some of the most common types of gliomas, are defined by their key molecular features resulting from tumor cell mutations.

Human glioma cells expressing human CD4, infected with an amphotropic retrovirus encoding the cDNA of the CD4 message.

Infects human brain primary glioma explant cells, producing persistant low levels of virus.

Bradykinin enhances invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migration.

Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology.

Simona thinks that this cell biological approach could help make sense of the heterogeneity of gliomas and improve our understanding of invasion overall: «These are key questions — we need to know how invasion is driven as it could have profound implications for therapy».

Gliomas, which originate in glial cells that support and protect neurons, account for about 70 % of brain cancers.

A phase 1 trial of a dendritic cell (DC) vaccine administered with imiquimod, a TLR7 agonist that stimulates the innate immune system, for patients with malignant glioma and glioblastoma (NCT01808820).

Now researchers at SciLifeLab have shown that one and the same cell of origin can give rise to different types of glioma.

U-M's internationally renowned Translational Neuro - Oncology Laboratory generates novel primary cell cultures from pediatric and adult glioma tissue samples to study mechanisms of glioma growth and targeted treatment response.

Of great interest, stem - like cells have also been discovered in some cultured cancer cell lines, including glioma (22, 23), ovarian (24, 25), liver (26), and prostate (27 — 29) cancer cells.

Glioma stem cells (GSCs) are a subpopulation of cells that contribute to tumor progression.

Man J, Shoemake S, Zhou W, Fang X, Wu Q, Rizzo A, Prayson R, Bao S, Rich JN, Yu JS, Sema3C Promotes The Survival and Tumorigenicity of Glioma Stem Cells Through Rac1 Activation.

Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem - Like Cells.

They found that the exposed rats were more likely to develop cancers, specifically malignant gliomas — a tumor of glial cells in the brain — and tumors in the heart.

2014 — Pathophysiology publishes a follow - up study to the Swedish study noting that the odds of developing a malignant and highly lethal brain cancer called glioma rose concurrently with increased cell phone use.

Gliomas arise from the supporting cells of the brain (glial cells) and include astrocytomas and oligodendrogliomas.

Glioma - These tumors arise from the supporting cells of the brain and include astrocytomas, oligodendrogliomas, glioblastoma multiforme and ependymomas.