Sentences with phrase «of gonadal hormone»

For some cancers of interest, not only may breeds vary in predisposition but also the possibility of interactions between gender, gonadal hormone influences, and timing of gonadal hormone alteration should be taken into account in selecting the model and in investigating causal factors to be explored.

While the study set out to estimate incidence rates of each disease related to age at neutering, patients were diagnosed at different ages and with differing durations of the disease as well as varying years at risk from the effects of gonadal hormone removal.

These subgroups included two biologically distinct groups representing the extremes of gonadal hormone exposure (i.e., dogs neutered before skeletal maturation at < 1 year of age and dogs that remained sexually intact for their entire lifetime).

We analyzed risk for bone sarcoma using months of gonadal hormone exposure as a continuous variable.

Because the database used in that study provided no information on age at gonadectomy, the study could not evaluate bone sarcoma risk in terms of duration of gonadal hormone exposure.

Lifetime gonadal hormone exposure of each dog was expressed in terms of total months of gonadal hormone exposure (i.e., number of months sexually intact).

Cooke will receive the award over the next five years to study how rising levels of gonadal hormones, such as testosterone and estrogen, change behavior, motivation and perception during puberty.

This is in agreement with findings in juvenile male and female rats with low levels of gonadal hormones.

Given the importance of gonadal hormones in growth and development, this cultural contrast invites an analysis of the multiple organ systems that may be adversely affected by neutering.

The striking effect of neutering in female Golden Retrievers compared to male and female Labradors, and male Golden Retrievers, suggests that for this gender and breed the presence of gonadal hormones has a protective effect against cancers over most years of the dog's life.

Because neutering can be expected to disrupt the normal physiological developmental role of gonadal hormones on multiple organ systems, one can envision the occurrence of disease syndromes, including those listed below, to possibly be affected by neutering as a function of gender and the age at which neutering is performed.

Not exact matches

If gonadal hormones alone control sex - specific brain function, the two halves of the bird's brain that controls song (known as the song circuit) would be uniformly masculine or feminine.

The experience can alter parts of the brain which in turn control the production of hormones (known as gonadotropin - releasing hormones, or GnRH) which then regulate gonadal (testicular) development.

Beyond that, high perceived stress strongly affects the control system of most hormones, which is the brain / body system known as the hypothalamic - pituitary - adrenal - thyroid - gonadal (HPATG) axis.

These findings suggest that variations in gonadal hormones during the menstrual cycle influence the experience of pain in healthy women.»)

Review biological implications of hormone imbalance (thyroid, gonadal, adrenal, and other hormone systems).

But some things to consider: a) the dose of your thyroid medication might need to be adjusted based on the symptoms of heart palpitations; b) there are many possible reasons that your testosterone level is low (e.g.: nutrient deficiencies, adrenal gland stress, hypothalamic / pituitary / gonadal axis dysfunction, liver dysfunction, etc.), and c) your thyroid may not be functioning optimally despite being on thyroid hormone.

Your endocrine pathway starts with the hypothalamus, affecting your pituitary, which in turn affects the function of your thyroid, then adrenals, gonadal hormones, and finally gut.

D - aspartic acid d - Aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo - pituitary - gonadal axis in resistance - trained men http://www.nrjournal.com/article/S0271-5317 (13) 00173 - 5 / abstract

For females, the gonadal hormone exposure subgroups were: spayed before 1 year of age; spayed between 1 and 5 years of age; spayed after 5 years of age; and sexually intact.

The possible mechanisms by which gonadal hormone exposure might protect against the development of bone sarcoma in both males and females are not immediately evident.

To determine whether there was an association between endogenous sex hormones and risk of bone sarcoma, relative risk (RR) of incidence rates and hazard ratios for bone sarcoma were calculated for dogs subdivided on the basis of lifetime gonadal hormone exposure.

However, in that study, age at neutering was not available, and thus, duration of exposure to gonadal hormones for each dog could not be determined.

This analysis was also deemed logical for pathophysiological reasons because a disruption of the growth plate closure by gonadal hormone removal in the joint developmental stage would be expected to apply to all the joint disorders.

Differences in the two breeds studied here could be due to differences in sensitivities of the growth plates to gonadal hormone removal.

Comparisons of cancers in the two breeds suggest that the occurrence of cancers in female Golden Retrievers is a reflection of particular vulnerability to gonadal hormone removal.

McGreevy PD, Wilson B, Starling MJ, Serpell JA (2018) Behavioural risks in male dogs with minimal lifetime exposure to gonadal hormones may complicate population - control benefits of desexing.

The relatively high occurrence of one or more of these cancers in intact male Goldens, coupled with the relative absence of an effect of neutering, except with regard to LSA, points to a relatively high underlying rate of cancer occurrence in this gender and breed that is not affected by gonadal hormone removal.

This may reflect a particular sensitivity of receptor sites of some potentially metastatic cancer cells to gonadal hormone removal and / or prolonged levels of the gonadotropin hormone, follicle stimulating hormone [28].

The effects of neutering in the first year of a dog's life, especially in larger breeds, undoubtedly reflects the vulnerability of joints to delayed closure of long - bone growth plates from gonadal hormone removal [26], [27].

In dogs with congenital hypopituitarism (pituitary dwarfism, see Juvenile - onset Panhypopituitarism), there may be variable degrees of thyroidal, adrenocortical, and gonadal deficiency, but clinical signs are primarily related to growth hormone deficiency.