Sentences with phrase «of grafted cells»

Although the success of the grafted cells is exciting, there's still a lot of work to be done to conclude whether the extra grey matter actually improves cognition.

«What was really exciting is that in both old and young brains, a small percentage of the grafted cells retained their «stemness» feature and continuously produced new neurons,» said Bharathi Hattiangady, assistant professor at the Texas A&M College of Medicine and co-first author of the study.

To apply in vivo imaging tools for non-invasive monitoring of the survival and growth of the grafted cells, as well as tools to reveal adverse immune / inflammatory reactions to the graft;

However, the Connexin 30 knockout mice had more grafted cells than the normal mice, and some of the grafted cells were found to express CONNEXIN 30.

Future work will attempt to increase the number of grafted cells and improve hearing ability.

The fact that Connexin 30 knockout mice had a higher number of grafted cells than normal mice, and that some of the grafted cells expressed CONNEXIN 30 is a very important finding when considering cell transplantation as a treatment for hereditary hearing loss caused by CONNEXIN deficiency.

Not exact matches

«It's important that it all be viable — if not, not only might cells die in the center of the graft, but they can release bad signals to remaining healthy cells in an «apoptotic cascade,» essentially saying, «Conditions are horrible, let's commit suicide.»»

«Finding the optimal conditions to avoid interfering with immune cells working to eradicate cancer while preventing graft rejection and GVHD is the holy grail of bone marrow transplant,» says Leo Luznik, M.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center.

The researchers also found that arteries and veins from the macaques» hearts grew into the new heart tissue, the first time it has been shown that blood vessels from a host animal will grow into and nurture a large stem - cell derived graft of this type.

This image shows an implanted graft of cardiac cells derived from human stem cells (green) meshed and beat with primates» heart cells (red).

Last week, the woman, who is in her 70s, had a patch of the cells measuring 1.3 × 3 millimetres grafted into her eye in a 2 - hour operation.

In this pilot study to test the safety of putting iPS - derived cells into humans, the six are all receiving a graft of new retinal pigment epithelial cells, which serve to maintain the eye's light - sensing cells.

In the current study, Yu - Shang Lee, PhD, of the Cleveland Clinic, together with Jerry Silver, PhD, of Case Western Reserve Medical School, and others, used a chemical that promotes cell growth along with a scar - busting enzyme to create a more hospitable environment for the nerve graft at the injury site.

Lymphocytes in the grafts of undifferentiated iPS cells were also expressing relatively high levels of genes known to be involved in hostile immune responses.

In contrast, lymphocytes in both types of endothelial cell grafts expressed higher levels of genes known to be involved in dampening the immune response and inducing self - tolerance.

Historically, clinicians evaluating a patient for transplant have sought to identify donor cells that are perfectly matched to the patient's cell type, which is considered to be the optimal approach to help ensure successful outcomes and to minimize risk of graft - versus - host disease (GVHD), a serious and potentially life - threatening complication that occurs when the donated immune cells attack the patient's cells as foreign tissue.

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

When grafted onto bald mice, the cells produced not only furry tufts but stretches of skin complete with the oil - producing glands that help keep it supple as well.

Currently, grafts are either sheets of skin taken from a donor site on the body, or layers of cells cultured in vitro from the patient.

Hina had developed the devastating immune reaction known as graft - versus - host disease, in which donor cells attack the walls of the gut, skin, lungs, liver, and sometimes — though rarely — even the patient's brain.

«The immune response to the iPS - derived endothelial cells and the aortic endothelial cells, and the longevity of the grafts, was very similar,» said Kooreman.

They found that, while the grafts of undifferentiated iPS cells harbored large numbers of T cells of only a few specificities — indicating a robust immune response — those found in grafts of the two types of endothelial cells were more diverse, suggesting a more limited response associated with a phenomenon known as self - tolerance.

«Preventing graft - versus - host disease and relapse after transplant requires a difficult balance of eliminating the bad, overactive effector T cells, without suppressing the good, regulatory T cells,» said Kean, who is also an associate professor of pediatrics at the University of Washington School of Medicine and a member of the Fred Hutchinson Cancer Research Center.

The treatment — a whole - body graft of genetically modified stem cells — is the most ambitious attempt yet to treat a severe form of epidermolysis bullosa (EB), an often - fatal group of conditions that cause skin to blister and tear off at the slightest touch.

Two approaches to fat grafting — injection of fat cells versus fat - derived stem cells — have similar effects in reversing the cellular - level signs of aging skin, reports a study in the April issue of Plastic and Reconstructive Surgery ®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

But stem cell biologist and physician Michele De Luca of the University of Modena and Reggio Emilia in Italy and his colleagues have been developing a way to counteract an EB - causing mutation by inserting a new gene into the cells used for grafts.

«Given the serious threat of graft - versus - host disease, new approaches to make stem cell transplants safer for patients remain a critical unmet need,» said Dr. Leslie Kean, the trial's principal investigator and associate director of the Ben Towne Center for Childhood Cancer Research at Seattle Children's.

The researchers found that PAI - 039 inhibited the migration of cultured human coronary artery smooth muscle cells, and prevented the development of blockages in arteries and bypass grafts in mice.

In fact, the new approach is similar to an established treatment for severe burns, in which sheets of healthy skin are grown from a patient's own cells and grafted over wounds.

A study published in Cell last year demonstrated that human and rat stem cells could be grafted onto the spinal cord of paralyzed rats, forming new nerves capable of communicating across the injury site.

When they grafted a set of cells from the region that they called the «organizer» into the side of another embryo, a second body would form, joined to its host like a Siamese twin.

To do this, they switched from using dead tumour cell samples to patient - derived tumour cell lines, in which fresh samples of a person's tumour are grafted onto mice and grown to the required volumes.

One of the biggest challenges for medical researchers studying the effectiveness of stem cell therapies is that transplants or grafts of cells are often rejected by the hosts.

A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD), an often life - threatening complication of stem cell transplants (SCT) used to treat leukemia and other blood disorders, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Lancet Haematology and in print in the January issue.

Wartman has a chronic form of graft - versus - host disease (GVHD), a debilitating consequence of blood stem cell transplants.

Another approach to taming the donor graft relies on a mixture of anti — T cell anti-bodies called antithymocyte globulin, which is produced in horses or rabbits.

Now, in a study recently published in the journal PLOS ONE, a team of scientists from VCU Massey Cancer Center have shown a genetic relationship between the reactivation of hCMV and the onset of graft - versus - host disease (GVHD), a potentially deadly condition in which the immune system attacks healthy tissue following a bone marrow or stem cell transplant.

Given to the patient shortly before the transplant, the infusion of antibodies theoretically reduces the host's residual T cells, minimizing the risk of graft rejection while eliminating T cells from the donor to thwart GVHD.

Additionally, it is possible to take small pieces of the patient's skin, expand these in the laboratory and then graft them back onto the patient as very thin sheets of cells.

A team led by the Hutch's Marie Bleakley and by Warren Shlomchik of the University of Pittsburgh School of Medicine in Pennsylvania removes naïve T cells from grafts with a magnetic system that uses monoclonal antibodies bound to iron beads.

«The unique aspect of our procedure, which no one else in the world is doing, is the formation of blisters as the source of donor cells combined with laser surgery to prepare the grafted areas.

The results, published online today in the Proceedings of the National Academy of Sciences, suggest that lacing the grafts with stem cells enhances blood flow and boosts the production of molecules that make and maintain erections, all of which makes for a better penis reconstruction.

That approach, which shuts down the hyperactive donor T cells when they first arrive, has not only allowed patients to tolerate grafts from increasingly mismatched hosts but, in several recent studies, has also cut rates of severe acute and chronic GVHD to less than 15 %.

The research team tested the hypothesis by transplanting cells onto the surface of mouse bone grafts and studying the cell behavior both in vivo — inside the animal — and in vitro — outside the body.

The current research team, which includes Dr. Minoda and Dr. Hiroki Takeda of Kumamoto University, and several researchers from Keio University, have successfully grafted human iPS - derived cells into the inner ear of embryonic mice, a feat with a high level of technical difficulty.

For example, he says, researchers studying infertility have grafted human testis and ovary cells under the skin of animals in an effort to better understand their development.

The team conducted investigations by grafting low - metastatic (LM) and high - metastatic (HM) melanoma tumour cells under the skin of mice.

«We preferentially delete «naive T cells», since they are the main subset of white blood cells that reject grafts,» Strober says.

Studies have shown that the clinical success of transplantation depends on the number and percentage of limbal stem cells in tissue grafts.

It has taken more than five years of graft, but at long last approval has been given for the first clinical trial using human embryonic stem cells (hESCs).