Tola EN, Mungan MT, Uğuz AC, Naziroğlu M. Intracellular Ca2 + and antioxidant values induced positive effect on fertilisation ratio and oocyte quality
of granulosa cells in patients undergoing in vitro fertilisation.
A mature egg, ready for fertilization, is covered with clusters
of granulosa cells.
Not exact matches
And with that, he began prying away the
granulosa cells clinging to the eggs, in order to get a better microscopic view
of the nascent embryos to see if they were developing properly.
From the time an egg begins to develop in one
of a woman's ovaries, the
granulosa cells serve as a communication system — signaling, for example, when the egg needs nutrients and proteins.
If you believe, for example, that
granulosa cells and other very early features
of ovarian ecology set up the polarities that ultimately determine the quality
of a human egg, as Albertini does, then certain techniques widely used in IVF may be subtly perturbing the very mechanisms that eggs use to establish a plan to build an embryo and maximize the chances that it will develop properly.
Van Blerkom had been seeing hints
of polarity since the 1970s, but one
of the major turning points occurred in 1996 when, by accident, his lab discovered that cells surrounding the developing egg — the same
granulosa cells that had piqued Albertini's interest — possessed a receptor very similar to the leptin receptor.
Mycotoxin zearalenone exposure impairs genomic stability
of swine follicular
granulosa cells in vitro Xue - Lian Liu, Rui - Ying Wu, Xiao - Feng Sun, Shun - Feng Cheng, Rui - Qian Zhang, Tian - Yu Zhang, Xi - Feng Zhang, Yong Zhao, Wei Shen, Lan Li International Journal
of Biological Sciences 2018; 14:294 - 305
Identifiication and characterization
of mesotocin and V1a - like receptors in a urodele amphibian, Taricha
granulosa.
Expression
of ER - alpha mRNA was similar in control and PCOS follicles in the
granulosa cells, but in the theca cells, ER - alpha concentrations were significantly increased in the PCOS samples, compared with the controls.
Similarly, in a rodent model
of PCOS, levels
of ERβ protein were decreased in the
granulosa layers
of cystic follicles.67 Idiopathic ovulatory dysfunction has been found to be associated with a G / A (1730) polymorphism in ERβ.2.
By the end
of the follicular phase, the luteinizing hormone surge results in ejection
of the oocyte and transforms the remaining follicle into the corpus luteum; small and large luteal cells are formed from theca and
granulosa cells, respectively.
During the first 2 - week period
of the cycle, theca cells produce androgens, and
granulosa cells aromatize androgens to estrogen.
The prolonged heat may also be the result
of persistent high level
of estrogen provoked by an ovarian cyst or by a
granulosa cell tumor
of the ovary.
Tumors
of ovarian stromal cells include
granulosa cell tumors, thecomas and interstitial cell tumors (luteomas).
Some studies have found breeds like Boxers, German Shepherds, Yorkshire Terriers, English Bulldogs to be at an increased risk for
granulosa - theca cell tumors, a type
of sex cord stromal cell tumor.