Sentences with phrase «of growth factor reduced»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Even so, we anticipate that housing market developments will be a factor at work in reducing the rapid pace of growth in domestic spending to something more moderate.

External factors will continue to reduce growth in the remainder of the year, but it is unclear whether this will be sufficient to forestall inflation risks.

Similar to capsaicin, tumor necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor necrosis factor (50).

These studies have demonstrated higher levels of the growth factors that improve healing and lower levels of the growth factors that are thought to reduce healing rates.

But successful approaches are converging on a few key areas: calorie restriction; reducing levels of insulinlike growth factor 1 (IGF - 1), a protein; and preventing oxidative damage to the body's tissues.

For example, molecules that inhibit the growth factor TGF reduce the stiffness and the spread of the RDEB cancer cells.

Of all the factors, variation in winter river flows had the strongest influence on salmon populations, reducing their growth rate.

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

According to the report, high levels of sFlt1 could result in a compromised vascular system by reducing the available amount of these growth factors in the blood supply.

Hippocampus: Involved in memory and navigation, the hippocampi of germ - free mice have reduced levels of molecules that sense serotonin and the growth factor BDNF.

They found that many of these genes were significantly reduced, notably TGF - β1, a critical growth factor in wound repair.

The researchers hypothesized that these free - floating copies of the receptor would serve as decoys, capturing fibroblast growth factor molecules and reducing stimulation of the cartilage cells» receptors.

Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1 / Jagged1 pathway.

Free Insulin - like Growth Factor Binding Protein - 3 (IGFBP - 3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase).

Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in the Testes of Male Mice Causes Subfertility, Reduces Sperm Numbers, and Alters Expression of Genes That Regulate Undifferentiated Spermatogonia.

Results: Fibroblast growth factor 2 (FGF2) treatment reduced expression of β - cell markers, (INS, MAFB, SLC2A2, SLC30A8, and GCK) and activated ectopic expression of MYC, HES1, SOX9, and NEUROG3.

Furthermore, we found that human IL - 15 mediated insulin - like growth factor - 1 production in CD215 + myeloid cells and blocking IGF - 1 reduced the tumor - promoting effect of IL - 15.

Multiple studies have so far confirmed that because of the reduced blood flow that accompanies prolonged muscle tension, all the major growth factors remain in the muscle tissue for longer, the end result being more growth.

Multiple studies have shown that training to failure on every set leads to increased resting levels of catabolic hormones and reduced anabolic growth factors, which makes frequent training to failure absolutely counterproductive.

It merely demonstrates that caffeinated coffee causes a rise in blood levels of a growth factor known as granulocyte colony stimulating factor (GCSF), which is significantly reduced in individuals with Alzheimer's and shown to improve memory in mice with Alzheimer's.

«Flavonoids and Vitamin E Reduce the Release of the Angiogenic Peptide Vascular Endothelial Growth Factor from Human Tumor Cells».

Researchers believe that a ketogenic diet reduces the production of insulin - like growth factor 1 (IGFT - 1), a hormone essential in the development of the bones and the muscles of kids and teenagers.

Intermittent fasting also reduces the production of insulin - like growth factor (IGF - 1).

Eat, Fast and Live Longer — Horizon Did you know reducing IGF - 1 (Insulin - Like Growth Factor 1) by fasting is one of the best ways to...

It also reduces free radical damage, along with levels of IGF - 1, a growth - factor hormone associated with aging, tumor progression and cancer risk.

Researchers report that curcumin reduces all pro-inflammatory molecules in cartilage cells and in membranes that line the joints, among them tumor necrosis factor — which destroys joint cartilage — and vascular endothelial growth factor, which promotes excessive growth of blood vessels in inflamed joints.

Eating foods high in this fat - soluble phytochemical (meaning that in order for our bodies to uptake it, it does need to be eaten with a fat) is correlated with a reduced risk of various cancers, including prostate, breast, and lung cancers due to its ability to bind to and deactivate insulin - like growth factors (IGF)-- these are the cells that often become cancer cells.

Cancer prevention Researchers have hypothesized that higher intakes of omega - 3s from either foods or supplements might reduce the risk of cancer due to their anti-inflammatory effects and potential to inhibit cell growth factors [60].

Did you know reducing IGF - 1 (Insulin - Like Growth Factor 1) by fasting is one of the best ways to reduce weight and stave off life threatening diseases such as cancer and diabetes?

Plant estrogens, are rich in hormone - modulating factors called phytoestrogens, many of which can actually help reduce harmful estrogen activity in the body, particularly related to reducing the growth and spread of cancer cells.

For example, rats fed a high - fat, refined - sugar diet show reduced amounts of growth factors called neurotrophins in the brain, and scientists suspect that something similar happens to sugar - loving humans.

Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice.

Enhanced fat burning through green and white tea - brown fat cells play key role 13.07.2017 Two cups of green tea daily results in more brown fat 25.04.2017 Animal study: half cup of green tea daily is life extending 15.04.2017 Speed up interval - training fat loss with supplement containing caffeine and green tea 19.01.2016 Green tea boosts fat burning after interval training 30.10.2015 Chin - Shin Oolong Tea contains growth hormone booster 02.10.2015 Green tea healthier and more effective on empty stomach 01.09.2015 EGCG speeds up muscle recovery after period of inactivity 19.05.2015 Green tea inhibits breakdown of fast muscle fibres during long - term inactivity 18.05.2015 Five cups of green tea daily rejuvenates skin 10.09.2014 Quercetin boosts inhibitory effect of green tea for prostate cancer 27.01.2014 Slimming supplement containing ECGC, resveratrol and Grape Seed Extract shown to work in human study 12.01.2014 Tea protects prostate against testosterone 10.12.2013 Green tea speeds up muscle recovery after heavy training 11.11.2013 EGCG protects liver and kidneys, and extends life expectancy 04.08.2013 EGCG and caffeine supplement keeps the cold out 26.02.2013 N - oleyl - phosphatidyl - ethanolamine & EGCG combo makes weight - loss diet easier 03.02.2013 Green tea has a slightly anabolic effect on strength athletes 14.01.2013 Cup of green tea with a meal makes it easier to eat less 18.12.2012 Green tea keeps athletes fit as the years go by 24.10.2012 Mushrooms, green tea reduce chance of breast cancer by factor of 10 13.10.2012 Combination of strength training and green tea gives elderly more muscle mass 12.10.2012 One cup of green tea burns five grams of fat 02.09.2012 Tiny amount of caffeine can burn fat — when combined with tea phenols 27.08.2012 Tea for temporary T boost 24.04.2012 Grow old healthily with green tea 11.03.2012 Tea drinkers have stronger bones 25.02.2012 Lose weight with Pu - Erh tea 17.08.2011 Tea supplement boosts T levels in animal study 30.10.2010 Almost no green tea in green tea sodas 13.10.2010 Drink green tea instead of water — and live longer 24.05.2010 Green tea stackers don't work without exercise 13.05.2010 Metastudy: slimming supplements with green tea do work 27.03.2010 Black tea reduces muscle soreness after training 20.03.2010 Cold brewed white tea contains most antioxidants 04.01.2010 Cup of tea inhibits uptake of mercury from fish 04.12.2009 Polyphenols in juice and tea clear bacteria from your teeth 22.10.2009 Drink three cups of tea a day and add five years to your life 11.09.2009 Bad breath from proteins?

The negative effects seem to lie in the capacity of some foods / nutrients to stimulate proliferative pathways that in turn stimulate development of acne — suspect foods include those with a high glycaemic load and milk.11, 43, 44 Other evidence comes from several studies reporting that the prevalence of acne varies significantly between different populations and is substantially lower in non-Westernized populations that follow traditional diets, 45 a common factor among these traditional diets being a low glycaemic load.46 Various studies have provided evidence that high - glycaemic - load diets are implicated in the aetiology of acne through their capacity to stimulate insulin, androgen bioavailability and insulin - like growth factor - 1 (IGF - 1) activity, whereas the beneficial effects of low - glycaemic - load diets, apart from weight and blood glucose levels, also include improved skin quality.44 The clinical and experimental evidence does in fact suggest ways in which insulin can increase androgen production and affect via induction of steroidogenic enzymes, 47 the secretion by the pituitary gland of gonadotropin - releasing hormone and the production of sex hormone - binding globulin.48 Insulin is also able to reduce serum levels of IGF - binding protein - 1 increasing the effect of IGF - 1.49 These insulin - mediated actions can therefore influence diverse factors that underlie the development of acne such as:

In addition, zinc deficiency reduces the secretion by T cells of interleukin - 4 (IL - 4), a growth factor for T - cell helpers (Dowd et al. 1986).

«Exercise, in particular, can reduce levels of cellular inflammation by lowering blood sugar levels and reducing insulin and insulin growth factors.

Indeed, unlike animal protein, plant protein has not been associated with increased insulinlike growth factor 1 levels28, 29 and has been linked to lower blood pressure,30 - 32 reduced low - density lipoprotein levels,32 - 34 and improved insulin sensitivity.35 Substitution of plant protein for animal protein has been related to a lower incidence of CVD36 - 39 and type 2 diabetes.40 - 42 Moreover, although a high intake of red meat, particularly processed red meat, has been associated with increased mortality in a recent meta - analysis of 13 cohort studies, 43 high consumption of nuts, a major contributor to plant protein, has been associated lower CVD and all - cause mortality.44 These results underscore the importance of protein sources for risk assessment and suggest that other components in protein - rich foods (eg, sodium, 45 nitrates, and nitrites46 in processed red meat), in addition to protein per se, may have a critical health effect.

In response to negative energy balance, mRNA translation and muscle protein synthesis may be down - regulated as a result of decreased nutrient and growth factor availability, causing reduced mTORC1 activation.

Second, they may reduce the risk factors of cardiovascular disease and may block the action of certain enzymes that contribute to cancer growth.

As a third factor, the report says the effort can only succeed through an strategy of finding quality charter operators, pointing out that the state charter association has taken steps in recent years to reduce the number of «under - performing» charters and «growth for growth's sake» is not the aim.

The District attempts to compensate for some of these factors, weighing special education status, English proficiency, attendance, and eligibility for free or reduced - price lunch — a common proxy for poverty — in developing growth predictions for students.

Even after adjusting for cause of death by free - radical diseases, the average lifespan of giant breeds like the Irish Wolfhound and St. Bernard was still lower than smaller breed dogs, suggesting that the factors responsible for reducing giant breed lifespan are likely to be a complex mix of morbidities linked to growth including, but not inclusively restricted to, free - radical release [29].

IMO the net result is rates of population growth will reduce, but rather slowly and not enough to be a huge factor in preventing dangerous climate change.

In essence Zhang proposes that the warming factors reduce the growth of sea ice which reduces ocean overturning allowing increased stratification of the ocean which in turn reduces ocean heat flux available to melt ice.

In the long run, much of the economic growth of developed economies is likely to involve less energy - intensive sectors because of demand - side factors such as 1) the amount of stuff people can physically manage is limited (even with rented storage space), 2) migration to areas where the weather is more moderate will continue, 3) increased urbanization and population density reduces energy consumption per capita, 4) there is a lot of running room to decrease the energy consumption of our electronic devices (e.g., switching to clockless microprocessors, not that I'm predicting that specific innovation), 5) telecommunication will substitute for transportation on the margin, 6) cheaper and better data acquisition and processing will enable less wasteful routing and warehousing of material goods, and 7) aging populations will eventually reduce the total amount (local plus distant) of travel per person per year.

(This will also reduce mold growth, the gradual rot of natural building materials, and other factors as well.)

So I struggle to see how it would reduce gdp growth, and its more likely to be neutral in effect, but of course when you factor in the growth destroying aspect of climate change, such a tax is effectively enhancing growth.

Although India's installed solar capacity almost doubled in 2016 to 12 GW, the reduction in this year's growth is attributable to many factors, including reduced exports, a declining share of industrial and agricultural production in GDP, reduced consumer demand, and both a sudden fall in money circulation attributable to demonetization late in 2016, and a goods and services tax introduced in 2017.

Reduced demand for property forced sellers to adjust their prices to meet the demands of a more cautious buyers» market, resulting in negative price growth in real terms when inflation is factored in.»