Sentences with phrase «of growth factors called»

For example, rats fed a high - fat, refined - sugar diet show reduced amounts of growth factors called neurotrophins in the brain, and scientists suspect that something similar happens to sugar - loving humans.

They first induced angiogenesis in mice through the injection of a growth factor called FGF - 2 and measured blood vessel development in the presence and absence of synthesised IP5.

Not exact matches

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Findings of the research, published April 22 in the journal Mucosal Immunology, reveal that a substance found in animal and human breast milk called epidermal growth factor, or EGF, blocks the activation of a protein responsible for unlocking the damaging immune cascade that culminates in NEC, a disease marked by the swift and irreversible death of intestinal tissue that remains one of the most - challenging - to - treat conditions.

They focused on the p75NTR receptor, a protein which is found on the tips of peripheral neurons and known to bind a small molecule called NGF (for nerve growth factor).

After deciphering this natural differentiation process, the investigators duplicated it in the laboratory dish by adding a sequence of proteins, called growth factors, to the fluid bathing the stem cells.

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

Vibration helped tissue to form new blood vessels — a process called angiogenesis — and also led to increased expression of pro-healing growth factors and signaling molecules called chemokines, Weinheimer - Haus said.

About 15 to 20 % of breast cancers are classified as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen receptor, the progesterone receptor, and HER2 (a member of the epidermal growth factor receptor family).

In 1991, Japanese researchers discovered that Lion's Mane contains two novel classes of nerve growth factor — molecules called hericenones and erinacines — that stimulate the differentiation and re-myelination of neurons.

«Scientifically, she worked on a project that not only revealed an important role for a specific growth factor (VEGF) in the physiology of an ocular structure called the ciliary body but she also demonstrated that there might be unexpected and undesired side effects from a widely used treatment for a variety of ocular diseases.

However, tumors produce high amounts of a protein called Transforming Growth Factor - Beta (TGF - β) that suppresses the activity of NK cells.

However, 2 years ago, Terry Smith of the Harbor - University of California, Los Angeles, Medical Center in Torrance and colleagues discovered that in patients with Graves disease — an autoimmune disorder that attacks the thyroid gland and eyes — fibroblasts make chemokines when so - called immunoglobulin G antibodies in the blood activate a protein called the insulin - like growth factor 1 (IGF - 1) receptor.

The new test instead looks for hGH's knock - on effects in the body — namely, increased production of insulin - like growth factor 1 (IGF - 1) and a substance called P3NP.

Fat - containing cells — especially those in the abdomen — behave like little hormone factories, he says, secreting estrogen, insulin, and a host of other so - called growth factors.

The amount of proteins called pro-fibrotic growth factors increases, thereby increasing stiffness of the dermis.

A growth factor called LIF tripled the number of oRG cells in growing minibrains by week 12.

The analysis also found that Asian / Pacific Islander women were more likely to be diagnosed with another subtype of breast cancer: so - called human epidermal growth factor receptor 2 (HER2)- overexpressing breast cancer.

One of these, called CTGF or connective tissue growth factor, was intriguing because its levels rose in the supporting cells, or glia, that formed the bridge in the first two weeks following injury.

In 1991, Robertson and her colleagues reported an unusual discovery involving a gene called Igf2, which is responsible for producing a protein known as insulin - like growth factor II (IGF - 2), important for the growth of many kinds of tissue in the developing fetus.

«It turns out that the same signal — the so - called epidermal growth factor (EGF) pathway — control both the formation of pipes and beta cells through polarity changes.

The team found that individuals with long - standing type 1 diabetes and diabetic enteropathy have altered colonic stem cells (CoSCs) and increased blood levels of a regulatory protein called insulin - like growth factor binding protein 3 (IGFBP3), which is produced in the liver.

In the U.K., an all - party parliamentary panel issued a report called «Return of the Population Growth Factor» and called for stronger efforts to slow that gGrowth Factor» and called for stronger efforts to slow that growthgrowth.

Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well - known «resistance» mutations in the gene called epidermal growth factor receptor (EGFR).

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

So Hoffman is now looking for leads among genes controlling the production of molecules called growth factors, which regulate cell growth and division.

However, in PKD, the growth factors shown to promote cyst growth reside in fluid trapped in the interior space of a cyst, called a lumen, to which IgG antibodies have no access.

Approximately 10 - 15 % of Caucasian and 30 - 35 % of Asian patients with NSCLC have a mutation in the epidermal growth factor receptor (EGFR), which can be successfully targeted with EGFR inhibitors called tyrosine kinase inhibitors (TKI), such as erlotinib, gefitinib and afatinib.

These biologic therapies use an antibody class called immunoglobulin - G (IgG) to bind to and prevent the activity of specific proteins or growth factors.

He realised there was a market for cheap copies of therapeutic proteins such as interferon alpha, erythropoeitin, and human growth factor — so called biogenerics — that were about to come off patent.

The reason it's called MGF — mechano growth factor — is that the mRNA [messenger RNA] of isoform 4 is elevated when mechanical stress is applied to muscle tissue.

In this study, the research group has found that a peptide called EPIDERMAL PATTERNING FACTOR - LIKE 2 (EPFL2) and its receptor protein, ERECTA family receptor kinases, control the amount of auxin during leaf tooth growth.

The growth of cancer cells is spurred by a family of transcription factors, called E2Fs.

«It's abdominal obesity, and even more specifically, levels of a protein called fibroblast growth factor - 2 that may be a better indicator of the risk of cells becoming cancerous.»

Studying mouse models of glaucoma, Ban, Apte and their colleagues identified a molecule in the eye called growth differentiation factor 15 (GDF15), noting that the levels of the molecule increased as the animals aged and developed optic nerve damage.

Thalidomide appears to pair up with a growth factor called PDGF - B to produce more of the smooth muscle cells that repair vessel - wall defects.

It is an inhibitor of a vascular endothelial growth factor, a cytokine called VEGF.

The team suspects the difference may be due to the expression of a gene that codes for a growth factor called bone morphogenetic protein 2 (Bmp2); expression was 30 % higher in the developing forelimbs of bats than it was in mice.

In addition, substances called growth factors, produced naturally in the brain, were more abundant in key regions on both sides of the brain in optogenetically stimulated, stroke - affected mice than in their unstimulated counterparts.

When Ralph Arlinghaus, a molecular biologist at the University of Texas MD Anderson Cancer Center in Houston, learned that growth factor — starved healthy cells release a protein called 24p3 that causes them to die, he wondered if leukemia cells also use the molecule to kill off their competition.

The experiment shows that β1 - integrin — one of 28 types of integrin — maintains a link between the stem cell and its environment, and interacts biochemically with a growth factor called fibroblast growth factor [FGF] to promote stem cell growth and restoration after muscle tissue injury.

Cancer biologist Cun - Yu Wang of the University of Michigan in Ann Arbor and his colleagues set out to determine the role of growth factors in a cancer called he

The research team, spearheaded by postdoctoral fellow Yajie Liang, Ph.D., wondered whether the cells» survival could also be enhanced with steady doses of a compound called basic fibroblast growth factor (bFGF), an «energy drink» that spurs cells to grow.

A new study by Dr. Norman Greenberg challenges the idea that prostate cancer can be treated successfully by blocking the activity of a protein called insulin - like growth factor, or IGF - 1.

It is in a class of drugs called growth factors (cytokines).

Normally, this gene turns on when a dog is growing in the womb to make a molecule called a growth factor that guides the proper formation of limbs and paws.

Other research has shown that oxygen - deprived cells in the retina produce a type of protein called vascular endothelial growth factor (VEGF), which triggers the growth of new blood vessels in the retina.

Since then, researchers have learned to mix stem cells with combinations of proteins called growth factors to make the cells grow into different types of cells.

As organs develop, growth factors and other signaling molecules often are produced from clusters of specialized cells called signaling centers.

The drug, marketed as Lucentis, targets a molecule called vascular endothelial growth factor (VEGF), a key player in the growth of blood vessels.