Sentences with phrase «of growth factors in»

Short chain fatty acids may modulate tissue levels and effects of growth factors in the gut and so modify gut development and risk of serious disease, including colo - rectal cancer.

In fact, research suggests aerobic exercise boosts the release of growth factors in the brain that spurs the development of new nerve cell connections, especially in an area of the brain called the hippocampus.

Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets.

Cancer biologist Cun - Yu Wang of the University of Michigan in Ann Arbor and his colleagues set out to determine the role of growth factors in a cancer called he

According to the report, high levels of sFlt1 could result in a compromised vascular system by reducing the available amount of these growth factors in the blood supply.

This finding is in accordance with earlier animal model studies, which have shown that physical activity increases the amount of growth factors in the brain and improves synaptic plasticity.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

The functional effectiveness of such electronic sharing systems has been one factor in the growth of telecommuting as an option for workers.

For companies experiencing hyper - growth, the difficulty of finding enough talented people — not just software engineers but also sales, marketing and design staff — in Canada's largest centres becomes a determining factor in how they grow.

Our same - store sales growth is generally attributable to several key factors, including: new product introductions; improvements in restaurant speed of service and other operational efficiencies; hospitality initiatives; frequency of guest visits; expansion into, and enhancement of, broader menu offerings; promotional activities and pricing.

Some of the possible excess in house prices could in the interval be tempered by factors such as income growth, regulatory changes and modest price corrections along the way.

But as we know, oil prices and Canada's overall economy will have a strong impact on the city's growth in the future, and the possible effects of the oil price drop were not factored into our calculations.

At this point, Dua believes, it's more valuable for the company to double its growth in a large market than it is to increase its growth by a factor of 10 in a smaller market, i.e. moderate growth in Chicago beats explosive growth in Tampa.

The negative growth rate of the first quarter, partially related to severe weather in the Northeast, also shows how dependent the economy is on external factors.

It wasn't immediately clear how much of the change reflected confidence that the tax - cut legislation moving through Congress will boost growth, or other factors such as pickups in business spending and global growth.

A report from CIBC World Markets recently predicted the stock market might fall 10 % — 15 % this summer due to a confluence of factors, including a weak U.S. housing market, increasing fiscal strain, expensive oil prices, sluggish corporate earnings growth and disruptions in global supply chains stemming from the Japanese crisis.

By contrast, economic growth in Canada contracted in the first half of the year and business investment — the most important factor in demand for imports — collapsed along with oil prices.

And while various troubling social factors, including unequal access to health care and the impact of the opioid crisis, have stalled the growth of the average U.S. life expectancy in recent years, odds are that America's higher earners will live longer — maybe much longer — than they expect.

WASHINGTON — Because of substantial wage growth, bonuses, and other positive economic factors, the Republican tax law is gaining in popularity with the American public after initially negative reviews, which is becoming a problem for Democrats looking to run on a cohesive economic message in 2018.

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

The ease of shopping from over one thousand brands inside one app could be seen as a major factor in the 20 % growth month over month for Spring.

It then throws in plenty of growth factors (direct government funding, networking support, connections to customers, heavy promotion to outside investors, and relaxed regulations) and incubates them for years.

Tom Wynn, director of affluent research at Spectrem, provided several factors for the increased confidence: the steady improvement in job growth, the steady increase in the major stock market indices since the spring, and a decrease in political ambiguity with the election season over, which has an effect on at least some people's outlook.

Mauro F. Guillà © n of the Wharton School and Department of Sociology at the University of Pennsylvania and Sandra L. Suà ¡ rez of Temple University's Department of Political Science explore the economic and structural factors that affect the growth of the Internet in different countries in their paper «Developing the Internet: Entrepreneurship and Public Policy in Comparative Perspective.»

The «static» score of the bill — the amount of projected debt added when economic growth is not factored in — shows that the deficit would grow by about $ 1.5 trillion in the decade after the bill is implemented.

«Business cycles do not succumb to age alone but rather to a confluence of factors like falling corporate profit margins, slowing productivity growth, and a sharp rise in real policy rates into positive territory.»

«This trend could be due to several factors (or a combination of them): more startups being targeted for acquihires as their growth slows, capital availability leading to more ready cash on - hand, and a general consolidation of certain industries (e.g., food delivery companies acquiring each other),» CB Insights wrote in a blog post.

Three factors will fuel this growth: an explosion of voice - enabled devices, generational gains in AI, and a strong consumer value proposition for voice payments.

After identifying all income and expenses, you should factor in the anticipated growth rate of your investments.

«Statistics show if you have a meaningful percentage of ownership and some communication that the employee's job impacts the value of the shares they have in their accounts, these companies outperform their peers by a factor of 10 percent on a compounded annual revenue and [EBITDA] growth basis,» says Josephs.

Readers are cautioned that these forward - looking statements are only predictions and may differ materially from actual future events or results due a variety of factors, including, among other things, that conditions to the closing of the transaction may not be satisfied, the potential impact on the business of Accompany due to the uncertainty about the acquisition, the retention of employees of Accompany and the ability of Cisco to successfully integrate Accompany and to achieve expected benefits, business and economic conditions and growth trends in the networking industry, customer markets and various geographic regions, global economic conditions and uncertainties in the geopolitical environment and other risk factors set forth in Cisco's most recent reports on Form 10 - K and Form 10 - Q.

«By managing according to both sets of financial results (Channel's actual numbers and projected after - tax numbers, which factored in the NOLs, depreciation, and other deductions), we were able to figure out when we'd have the cash to support growth - related expenditures,» says Klein.

Returns from that era were boosted by a confluence of factors that are unlikely to come together again: declines in inflation and interest rates, strong global GDP, low corporate tax, and rapid growth in China.

Maury Obstfeld, economic counsellor and research department director at the IMF, told CNBC Monday that there was a broad cyclical upswing but many of the factors driving growth were temporary in nature.

«While we see a potential drop in total number of U.S. jobs created in 2017, as reported by Kiplinger, as well as an overall expected drop in GDP growth, the cannabis industry continues to be a positive contributing factor to growth at a time of potential decline,» says De Carcer in a statement.

Some risk factors the company listed in the filing include slowing growth of its user base and a decline in demand for its advertising products.

All the best, I realized that I left the growth factor a bit lacking in that message, but I also think you will find that in most investment senerios the compounding of the dividend / income is what drives portfolio performance rather than capital gains.

Stress, as defined by the Jobs Rated methodology, is determined by 11 factors: travel, deadlines, working in the public eye, competitiveness, physical demands, environmental conditions, hazards encountered, the life of oneself or others at risk, meeting and interacting with customers and / or the public, and the potential for job growth.

The portfolio management team uses a variety of investment strategies to search for companies suitable for investment in the fund, including factors such as growth in earnings, return on equity, and revenue.

In our view, some of the upward surprises come from factors that are unlikely to keep adding to economic growth at the same pace.

Rapid demand growth; commodity price volatility; the influence of a broad range of global conditions on wages: all these factors can trigger large changes in relative prices, and this makes the job of capturing underlying inflation harder.

The importance of financial integrity — The single most important factor in evaluating a growth company for long - term investment is its ability to operate profitably and generate capital internally.

In the profiles of successful emerging growth companies, these same factors emerge time and time again.

Given the persistence of these factors, our latest forecasts have incorporated a flatter profile for consumption growth than has been the case in previous forecasts.

GDP growth likely stalled in the fourth quarter of 2015, pulled down by temporary softness in the U.S. economy, weaker business investment and several other temporary factors.

The fashionable view at the Federal Reserve and elsewhere when Yellen took office in 2014 was that growth was slow despite very low interest rates because of «headwinds» — transitory factors associated with the financial crisis that would soon recede.

A number of factors have contributed, including concerns about dropping oil prices, slowing growth in China and geopolitical tensions (among them, concerns over the Syrian civil war and refugee crisis and ISIS attacks).

Alan Abelson presents an interesting chart in the latest issue of Barron's, showing that if extraordinary charges and option dilution is factored into earnings, growth in earnings per share from 1995 to 2001 drops to zero.

In the long run, however, the suburban office sector should do quite well, she adds, citing several factors that favor the category in terms of future growtIn the long run, however, the suburban office sector should do quite well, she adds, citing several factors that favor the category in terms of future growtin terms of future growth.

Combining this with poor sales growth results in a dismal outlook for earnings 3) the pressure on earnings will continue to hurt capital spending, which is usually just a magnified image of earnings, 4) the same factors will continue to raise default rates, causing earnings problems and debt downgrades among banks and financial companies, 5) earnings shortfalls will also lead to continued job cutbacks, with the unemployment rate rising to at least 5.5 % (indeed, once the unemployment rate has advanced by 0.5 % from its lows, it has never reversed until rising by least 1.5 % off those lows).