Sentences with phrase «of growth factors involved»

Platelets also contain a remarkable array of growth factors involved in healing.

Several research groups are pursuing gene therapy approaches to regenerate skin, such as using genes to control expression of growth factors involved in skin healing.

Not exact matches

Whatever pathological shape one's image of God assumes, this factor is probably also involved in its construction: a basic refusal to recognize and accept one's own inherent proclivities for growth and psychic maturation.

Another reason not to fixate on a number on a growth chart is that your baby's well - being involves a variety of factors, including development, temperament, and activity level, not just growth.

«Considering the large portion of the green industry involved with growing plants in containers and the importance of understanding the physiology and morphology of roots, the factors that influence root growth in container production should be continually investigated,» they wrote.

These treatments involve regular injection of vascular endothelial growth factor inhibitors (anti-VEGF) into the eye.

In 1991, Robertson and her colleagues reported an unusual discovery involving a gene called Igf2, which is responsible for producing a protein known as insulin - like growth factor II (IGF - 2), important for the growth of many kinds of tissue in the developing fetus.

«The most intriguing of these genes is FGFRL1, which has a cluster of amino acid substitutions unique to giraffe that are located in the part of the protein that binds fibroblast growth factors — a family of regulators involved in regulating many processes including embryo development,» Cavener said.

Hippocampus: Involved in memory and navigation, the hippocampi of germ - free mice have reduced levels of molecules that sense serotonin and the growth factor BDNF.

«Discovering the factors involved in granuloma control vs those not able to control bacterial growth is a critical step in potentially developing treatments that could «freeze» granulomas into a protective state in the two billion latent carriers,» explains Grace Peng, Ph.D., Director of the NIBIB program for Mathematical Modeling, Simulation and Analysis.

Thus, future strategies for repairing the central nervous system might involve concocting even more potent mixtures of growth factors, like Sofroniew's «carrot,» that could be continuously infused or implanted near a patient's injury.

Researchers are also targeting growth factors involved in new bone formation, with promising results in techniques using transplantation of genetically modified donor bone.

In a previous study of Pygmy genomes, Tishkoff and colleagues had found variants in genes involving human growth factor, which the pituitary gland produces to regulate height.

In addition to causing proteins to be secreted through general pathways from the cell and pathways involving metalloproteases, PMA specifically causes activation of an epidermal growth factor receptor (EGFR).

This protease activates hepatocyte growth factor (HGF) and urokinase plasminogen activator (uPA), two proteins thought to be involved in the growth and motility of cancer cells, particularly carcinomas, and in the vascularization of tumors.

To this end we will combine growth factor receptor mutants involved in DC generation aiming at generating a mouse mutant devoid of DC.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

GSK3 (Glycogen Synthase Kinase - 3) is a signaling mediator involved in a variety of different signaling pathways including WNT, growth factors, insulin, and Hedgehog pathways.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

His graduate work at Yale University involved making lots of mutations in the transmembrane region of the epidermal growth factor receptor (EGFR) and collecting data on which mutations affected dimerization.

The epidermal growth factor receptor (EGFR) pathway is a complex signaling cascade that is involved in the development and progression of cancer.

We already have evidence that endocytosis is involved in the spatial restriction of motogenic signals, leading to localised actin remodelling in response to growth factor stimulation (14).

These results, also presented at the 2015 European Cancer Congress (ECC2015, abstract # 5BA) today, which involve the group of 1,626 patients with a Recurrence Score between 0 and 10, demonstrated that 99.3 percent of node - negative, estrogen receptor (ER)- positive, human epidermal growth factor receptor 2 (HER2)- negative patients who met accepted guidelines for recommending chemotherapy in addition to hormonal therapy, had no distant recurrence at five years after treatment with hormonal therapy alone.

104 Several hormetic response pathways have been identified involving enzymes (kinases and deacetylases including Sirtuins), transcription factor - regulation the expression of several major categories of proteins including chaperones, antioxidant enzymes and growth factors.

Unlike other breast cancers that involve hormone receptors and HER2 receptors, this aggressive form of cancer relies on genetic therapeutics aimed at repairing celluar DNA and keeping epidermal growth factors from sending cellular signals.

Another way exercise supports executive - level brain activity is explained by an Irish study published in the journal Physiology + Behavior in 2011, which revealed that exercise stimulates production of brain - derived neurotrophic factor (BDNF), a protein involved with the growth of new neurons.

Children with asthma have lower vitamin A levels than children without asthma, and the degree of vitamin A deficiency they exhibit is directly proportional to the severity of their asthma.37, 38 In cell experiments, vitamin A eliminates the response of bronchial smooth muscle cells to growth factors that characterizes the asthmatic reaction39 and suppresses the activity of mast cells, which are involved in asthmatic or other reactions mediated by histamine or other inflammatory chemical messengers called leukotrienes.40 Consistent with studies in isolated cells, vitamin A deficiency causes asthmatic bronchial hyper - reactivity in live rats.41

This represents a small example of the hundreds of growth factors, proteins, and regenerative cells involved in the regenerative process that takes place when these cells are injected into a damaged joint.

I play a lot of football, and thus train a lot, which involves extensive running etc. its often said that cardio can be detrimental to muscle growth — I need to gain strength, and am struggling to gain mass — could this be a contributing factor?

Even recently, a pre-Super Bowl scandal emerged involving Baltimore Ravens player Ray Lewis, who is being accused of purchasing «deer antler spray» containing Insulin - Like Growth Factor - 1 (IGF - 1), about which I wrote in the article Could Your Pet Be Taking a Substance Banned by the NFL?

Studies of nutritional risk factors involved in osteochondrosis have identified free - feeding and overfeeding — especially of high - energy foods designed for rapid growth — as contributors.

In the long run, much of the economic growth of developed economies is likely to involve less energy - intensive sectors because of demand - side factors such as 1) the amount of stuff people can physically manage is limited (even with rented storage space), 2) migration to areas where the weather is more moderate will continue, 3) increased urbanization and population density reduces energy consumption per capita, 4) there is a lot of running room to decrease the energy consumption of our electronic devices (e.g., switching to clockless microprocessors, not that I'm predicting that specific innovation), 5) telecommunication will substitute for transportation on the margin, 6) cheaper and better data acquisition and processing will enable less wasteful routing and warehousing of material goods, and 7) aging populations will eventually reduce the total amount (local plus distant) of travel per person per year.

I would not have expected this to be the case as the decomposition process involves oxidation reactions that are exponential functions of temperature while the alarmists have been been arguing for years that the plant growth process is limited by, and dependent on, factors other than just temperature.

It is anticipated that this will involve assessing Indigenous need (including by mapping it against demographic factors such as projected growth of the population and mobility within regions) and mapping government expenditure as well as identifying the capital within the region.

STAT6 is part of the STAT family of transcription factors, its phosphorylation in response to cytokines and growth factors activates the transcription of many genes involved in the immune system such as interleukin 4 (IL - 4).

The factors involved in the choosing of markets include home prices, rents, vacancies, historical trends, employment and population growth.