Based on these intriguing observations, the researchers set out to identify the factors that influence the
composition of gut microbes during insect development.
The
community of gut microbes — known as the microbiome — can affect the development of a baby's immune system and the ability to extract energy from food, the researchers said.
According to a study in mice and a small group of human volunteers, the internal
clocks of these gut microbes sync up with the clocks of their hosts.
Each individual's
community of gut microbes is unique and profoundly sensitive to environmental conditions, beginning at birth.
Beginning with the trip through the birth canal, every minute counts in the early effort to launch the healthiest - possible
balance of gut microbes.
In a new study published online today in Nature Communications, an international team of researchers offers the first comprehensive look at the full - scale diversity
of gut microbes in one group of hunter - gatherers and how the bacteria unique to them might function in their guts and affect their health.
Reporting this week in mSphere, an open - access journal of the American Society for Microbiology, the researchers found that the Inuit harbor a composition and
diversity of gut microbes remarkably similar to their urbanized, westernized counterparts in urban Montreal.
By contrast, mice raised in the germ - free cages showed worse motor symptoms when they either were treated with microbial metabolites called short - chain fatty acids or received fecal transplants
of gut microbes from patients with Parkinson's disease.
Additionally, fecal
transplant of gut microbes from obese mice to GF mice results in greater adiposity in the GF recipients than fecal transplants from lean donors (2).
Meanwhile, the latest book by U.S. neurologist and author David Perlmutter, Brain Maker: The
Power of Gut Microbes to Heal and Protect Your Brain — for Life, has quickly found its way onto The New York Times bestseller list, with alluring tips on how to achieve neurological wellness through dietary changes and probiotic enemas.
The next step for his lab will be to test the hypothesis that these protective pTregs in diabetes are dependent on gut microbes, and that this mechanism could explain the
influence of gut microbes on type 1 diabetes risk.
Animals in each of the three groups — gastric bypass, sham surgery, and restricted diets — were killed and
samples of their gut microbe communities diluted.
«Co-infection with two common gut pathogens worsens malnutrition in mice: New mouse model could help reveal the impact
of gut microbe interactions in malnourished children.»
The findings, published in the journal eBiomedicine, highlight the critical
role of gut microbes in energy balance and suggest that unhealthy microbiome shifts can lead to weight gain and obesity by altering resting metabolism.
In the second study, Thomas Gajewski at the University of Chicago and colleagues noticed differences in how quickly tumours grew in two groups of mice with different
sets of gut microbes.
Without the
trigger of gut microbes, a baby's immune system is skewed towards allergies or autoimmune disease — animal studies suggest that there's a specific window of time when this happens and when probiotics can have the greatest impact.
There are also
plenty of gut microbes in both places (which means that the pillows were seeded with what scientists delicately refer to as «fecal contamination»).
The hipster insects serve up beneficial bacteria that may help baby bees develop a healthy
blend of gut microbes, researchers report online August 7 in Applied and Environmental Microbiology.
«Like zebrafish, we have this rich
source of gut microbes that have figured out how to coexist with us and soothe the immune system,» she says, adding that «there is enormous potential to harness those mechanisms» to address ailments such as inflammatory bowel disease and other chronic inflammation.
The big step forward, Cummings says, is what the researchers did next: They performed a
series of gut microbe transplants.
Antibiotic treatment reduced motor deficits and molecular hallmarks of Parkinson's disease in a mouse model, whereas
transplantation of gut microbes from patients with Parkinson's disease exacerbated symptoms in these mice.
Quantifying the relative abundances of three ubiquitous
genera of gut microbes — Bacteroides, Lactobacillus and Bifidobacterium — revealed that populations of Bacteroides andLactobacillus peter out in a predictable manner, the team reported in June in the Journal of Forensic Sciences.
But soon after the corpses ruptured — caused by the
activity of gut microbes — their native microbial community was replaced by oxygen - loving microbes in the air and the soil.
GOOD BUGS Getting the right
infusion of gut microbes in the first three months after birth may reduce children's risk of getting asthma (and the need for inhalers) later, a new study suggests.
Profiling the expression patterns of host genes revealed that the insect significantly increases the abundance of B vitamin transporters and activation enzymes when reared in the
absence of its gut microbes.
Nunez, Kim, Sakamoto and their colleagues carried out a careful series of experiments using both newborn and adult germ - free mice, and samples
of gut microbes taken from the feces of 4 - day - old, 12 - day - old and 16 - day - old normal mice.
And while scientists have made strides in recognizing various
strains of gut microbes by identifying their molecular DNA signature, they still have a long way to go to determine what each does and how each functions, Bienenstock says.
Terry Hwa's lab has been working on quantitative descriptions of how genes, proteins and chemicals work together to coordinate the physiological responses of the gut bacterium E. coli, and is more recently studying the interaction
of gut microbes with each other and with the host environments.
They found that the abundance of Th - 17 cells in the gut is tied to the
presence of gut microbes called segmented filamentous bacteria.
If none of these are working, it may be time to consult a holistic doctor, functional medicine expert, or nutritionist on a gut - healing plan — an examination and
assessment of your gut microbes and a specific diet, exercise, supplement, and rest program.
They specialize... This means that a fiber - rich diet can nourish a wide
variety of gut microbes and, conversely, that a low - fiber diet can only sustain a narrower community.»