Others speculated that, like the malaria drug chloroquine, artemisinin frustrates the removal
of haem, a toxic byproduct formed during the parasite's consumption of human hemoglobin.
For instance, to improve drug activation at ring stage, we can explore enhancing the level
of haem biosynthesis in the parasite.
Not exact matches
The study also showed that the main activator
of artemisinin is
haem, a specific iron - containing compound, either biosynthesised by the parasite at its early developmental ring stage, or derived from haemoglobin digestion in the later stages.
The drug activation level was found to be much lower in ring stage parasites, given that artemisinin activation requires
haem, which is
of much lower abundance and is biosynthesised by the parasite.
Vitamin B12 is the most complicated
of an essential group
of bio-pigments which includes
haem, the red pigment in haemoglobin, and chlorophyll, the green pigment in plants.
Some chemists, including Albert Eschenmoser at the University
of Zurich, think that molecules based on the corrin ring system
of vitamin B12 could be older in evolutionary terms than the porphyrin - based ring systems in
haem and chlorophyll.
In animals the path from here onwards involves a series
of steps eventually leading to
haem, while in plants it leads to chlorophyll.
«Plant foods also contain non-
haem iron, which some experts believe may be a healthier form
of iron than
haem iron, which is found in meat.»
There are two types
of dietary iron:
haem iron (found in animal foods) and non-
haem iron (found in plant foods).