Conditional telomerase induction causes proliferation
of hair follicle stem cells.
The bulge is where the majority
of the hair follicle stem cells reside, and these can give rise to multipotent progenitor cells.
The group observed that, at the cellular level, one of the side effects of the diet was an expansion
of hair follicle stem cells, leading to increasing hair follicle growth and retention rates.
Not exact matches
Prof. Jean - Christophe Marine (VIB - KU Leuven): «Unexpectedly, this ability to divide and contribute to melanoma development contrasted with the activities
of other
cell populations, such as melanocyte
stem cells found in
hair follicles, for instance.
«Dermal papilla
cells give rise to
hair follicles, and the notion
of cloning
hair follicles using inductive dermal papilla
cells has been around for 40 years or so,» said co-study leader Colin Jahoda, PhD, professor
of stem cell sciences at Durham University, England, and co-director of North East England Stem Cell Institute, who is one of the early founders of the fi
stem cell sciences at Durham University, England, and co-director of North East England Stem Cell Institute, who is one of the early founders of the fi
cell sciences at Durham University, England, and co-director
of North East England
Stem Cell Institute, who is one of the early founders of the fi
Stem Cell Institute, who is one of the early founders of the fi
Cell Institute, who is one
of the early founders
of the field.
«By analyzing mice with the WNT10A mutation, as well as tissues from human patients with WNT10A mutations, we found that WNT10A regulates the proliferation, but not the maintenance,
of stem cells in
hair follicles,» said Sarah Millar, PhD, vice chair for Basic Research in the Department
of Dermatology.
First, imaging experiments revealed that Tregs have a close relationship with the
stem cells that reside within
hair follicles and allow them to regenerate: the number
of active Tregs clustering around
follicle stem cells typically swells by three-fold as
follicles enter the growth phase
of their regular cycle
of rest and regeneration.
Within every
hair follicle is a population
of melanocyte
stem cells.
What they did not know in detail is what happens after those
stem cells move down to the base, or bulb,
of hair follicles and which
cells in the
hair follicles produce SCF — or that
cells involved in
hair shaft creation make the KROX20 protein, he said.
Scientists already knew that
stem cells contained in a bulge area
of hair follicles are involved in making
hair and that SCF is important for pigmented
cells, said Dr. Le, a member
of the Hamon Center for Regenerative Science and Medicine.
Stem cells in hair follicles prove the viability of adult stem cells to not only clone, but also possibly create embryonic stem ce
Stem cells in
hair follicles prove the viability
of adult
stem cells to not only clone, but also possibly create embryonic stem ce
stem cells to not only clone, but also possibly create embryonic
stem ce
stem cells.
Waves
of Wnt signalling spreading from
hair to
hair activate
follicle growth, followed by waves
of BMP signalling that shut down the
stem cells in these
follicles, halting growth.
«This is the first time anyone has made scalable amounts
of epithelial
stem cells that are capable
of generating the epithelial component
of hair follicles,» Xu says.
The epithelial
stem cells, when implanted into immunocompromised mice, regenerated the different
cell types
of human skin and
hair follicles, and even produced structurally recognizable
hair shaft, raising the possibility that they may eventually enable
hair regeneration in people.
But it hasn't been possible to generate sufficient number
of hair -
follicle - generating
stem cells — until now.
They then converted the iPS
cells into epithelial
stem cells, normally found at the bulge
of hair follicles.
First, a
hair follicle contains epithelial
cells — a
cell type that lines the body's vessels and cavities — as well as a specific kind
of adult
stem cell called dermal papillae.
In Vivo Monitoring
of Survival and Proliferation
of Hair Stem Cells in a
Hair Follicle Generation Animal Model
Title: Lgr6 marks
stem cells in the
hair follicle that generate all
cell lineages
of the skin Authors: Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H Date: March 2010 Publication Details: Science.
«Engineering blood vessels for bypass surgery, promoting the formation
of new blood vessels or regenerating new skin tissue using
stem cells obtained from the most accessible source —
hair follicles — is a real possibility,» said Stelios T. Andreadis, Ph.D., co-author
of the paper in Cardiovascular Research and associate professor in the Department
of Chemical and Biological Engineering in the UB School
of Engineering and Applied Sciences.
They conducted a study in mice and found that the
stem cell that produces all the different
cells of the skin actually lives in
hair follicles.
Melanocytes have the capacity to respond to a diverse number
of extracellular signals, including UVR, endocrine signaling cascades that occur during pregnancy, micro-environments
of the
stem cell hair bulge vs. differentiated
hair follicle niches, and hypoxic conditions found in metastatic melanoma tumors.
Recent work reveals that keratinocyte holoclones contain self - renewing
stem cells and that the ability to form a holoclone is an intrinsic property
of the adult
stem cells of the
hair follicle (4).
The delicate interplay
of two chemical signals coaxes
stem cells into becoming
hair follicles, according to new research by scientists at the Howard Hughes Medical Institute at The Rockefeller...
Your
hair — or lack
of hair — is the result
of a lifelong tug -
of - war between activators that wake up, and inhibitors that calm,
stem cells in every
hair follicle on your body, according to Cheng - Ming Chuong, M.D., Ph.D.,
of the University
of Southern California (USC).