Sentences with phrase «of hapten»
The present study employed Ighb scid mice reconstituted with normal lymphocytes from young (2 -3-mo-old) and aged (20 -25-mo-old) donors and immunized with a protein conjugate of the hapten (4 - hydroxy -3-nitrophenyl) acetyl (NP) to determine whether the molecular changes in antibody repertoire reflect senescence in the B cells or whether they are mediated by the aging helper T lymphocytes.
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Random - bred Hartley strain guinea pigs which do not respond immunologically to conjugates of hapten and poly - L - lysine mere mated with heterozygous guinea pigs which do.