Sentences with phrase «of hemagglutinin»

We found that the mutations in two amino acids out of more than 300 in one key region of the hemagglutinin protein were enough to lower efficacy to 19 percent against all circulating strains.»

Like different picks in a locksmith's tool, the 17 known subtypes of hemagglutinin, a surface protein on influenza strains, match different sialic acid receptors on a host cell.

They target and bind tightly to strain - specific regions of hemagglutinin (HA) and neuraminidase (NA) proteins on the virus.

Like kids with a sweet tooth, the immune system gets most excited about the top part of the hemagglutinin lollipop, and makes antibodies against it.

The researchers trawled their gigantic library of more than 27 billion human antibodies to determine which molecules latch onto H5, the version of hemagglutinin carried by the avian flu virus.

After 2 doses of an H7N9 formulation containing 15 µg of hemagglutinin given without adjuvant, with AS03 adjuvant, or with MF59 adjuvant, the proportion achieving an hemagglutination inhibition antibody (HIA) titer of 40 or higher was 2 percent without adjuvant (n = 94), 84 percent with AS03 adjuvant (n = 96), and 57 percent with MF59 adjuvant (n = 92).

Fiers investigated the nucleotide sequence of the hemagglutinin gene of this duck virus and found that it was indeed very closely related to the strain that started the 1968 Hong Kong outbreak.

(These proteins serve as the basis for influenza nomenclature; for instance, the H5N1 virus refers to specific classes of hemagglutinin and neuraminidase, which in this example correspond to an avian flu subtype.)

This selection also provided a broad representation of hemagglutinins across the phylogenetic tree.

Four amino acids of the hemagglutinin protein were frequently changed by mutations in the cancer patients» viruses and popped up years later in flu strains worldwide, too.

The annually updated trivalent flu vaccine for the 2005 - 2006 season consists of hemagglutinin (HA) surface glycoprotein components from influenza H3N2, H1N1, and B influenza viruses.

Researchers name flu viruses based on the type of hemagglutinin (HA) and neuraminidase (NA) proteins they containhence the numbers after «H» and «N» in H5N1.

The current types of flu circulating are H3N2 and H1N1, named after the configuration of hemagglutinin and neuraminidase.

There are 18 different kinds of hemagglutinin and 11 kinds of neuraminidase.

One approach for a universal vaccine is to configure a molecule that contains almost all known mutations of hemagglutinin.

Teams are developing flu vaccines that prompt the body to respond to the stem of the hemagglutinin protein.

Lisa A. Jackson, M.D., M.P.H., of Group Health Research Institute, Seattle, and colleagues randomly assigned 980 adults (19 through 64 years or age) to receive the H7N9 vaccine on days 0 and 21 at doses of 3.75 µg, 7.5 µg, 15 µg, and 45 µg of hemagglutinin with or without AS03 or MF59 adjuvant.

The method is much less cumbersome than dealing with chicken eggs, and because the vaccine is so easy to produce, the company intends to use 135 micrograms of hemagglutinin in each dose of vaccine — 3 times higher than current flu vaccines — in hopes of getting better protection.

«A couple of other genes are also evolving rapidly and we know nothing about them,» he says, adding that they may affect the behavior of hemagglutinin.

Using a combination of laboratory assays and computer algorithms, the team tested various mutations in HB36.5, looking for single amino acid changes that would increase how tightly the protein bound to a diverse group of hemagglutinins.

Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.

It binds the stalk of hemagglutinin, a less variable region of the flu virus that is also the target of proposed universal vaccines.

The influenza virus invades cells by puncturing the cell wall with the tiny spikes of hemaGglutinin that cover its surface.

The gene, called H5, is one of 16 subtypes of hemagglutinin, a protein that binds the avian influenza virus to the cells it infects.

Immunochemist Wayne Marasco of Harvard Medical School in Boston and colleagues discovered an unchanging part of hemagglutinin that might provide a better target when they were looking for antibodies that neutralize the avian flu.

The subtype behind the 2009 «swine flu» pandemic is H1N1, which has the same version of neuraminidase as H5N1, but a different version of hemagglutinin.

Today in PLOS Pathogens, scientists report that they've designed small molecules to target a particularly vulnerable region of hemagglutinin, one of the two proteins that jut from the viral surface like a flower.

In escaping the immune system, the new mutations can inadvertently disrupt this golden binding point, which can be remedied by adding a sugar molecules in the just the part of the hemagglutinin.

What's more, he adds, the vaccine can be altered to carry genes from any of the hemagglutinin subtypes.

They expressed two versions of hemagglutinin — one adapted to eggs and one adapted to humans — on one virus particle.