Sentences with phrase «of hematopoietic»

Furthermore, there is evidence suggesting an association of replication stress on rDNA loci with the aging of hematopoietic stem cells, adding more evidence to the general function of the nucleolus in genome integrity and aging.

It is a cofactor in several oxidative enzymes vital to the function of hematopoietic, vascular and skeletal tissues, as well as the structure and function of the nervous system, including superoxide dismutase (oxygen radical scavenger), cytochrome - c oxidase (mitochondrial respiration), lysyl oxidase (collagen and elastin synthesis) and ceruloplasmin ferroxidase / haephestin (iron metabolism).

Our study may implicate haploinsufficiency of protein - coding genes as a general mechanism of aging of the hematopoietic system and of aging - associated disorders more generally and provide new insights into the genetics of aging and healthspan.

Laboratory model of immune system overcomes ethical constraints on studies of hematopoietic stem cells in humans.

Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.

Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown.

Cuvelier GD, Schultz KR, Davis J, Hirschfeld AF, Junker AK, Tan R, Turvey SE.: Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency.

While Wang et al. [12] recently showed no expansion advantage of hematopoietic cells derived from human ES cells, Bowles and colleagues [13] saw increased expansion.

Functional rescue of dopaminergic neuron loss in Parkinson's disease mice after transplantation of hematopoietic stem and progenitor cells.

Previously the long - term benefits of hematopoietic stem - cell transplantation in cerebral adrenoleukodystrophy (ALD) are thought to be mediated by donor - derived replacement of myeloid derived cells, possibly including microglial cells.

When patients receive a bone marrow transplant, they are getting a new population of hematopoietic stem cells.

The major hindrance to exploiting ES cells has been the lack of established protocols for efficient derivation of hematopoietic cells.

In a similar manner, the induction of hematopoietic (cluster 20, day 3.5 +4 = E7.5) and cardiovascular - specific (cluster 12, 3.5 +5 = E8.5) genes follows the chronological order of the appearance of blood islands and the formation of the heart tube during embryonic development [50], [51].

We further describe a mesenchymal sub-population with stem cell - like characteristics that gives rise to both lineages and, at the same time, acts as a principal component of the hematopoietic niche by promoting competitive repopulation following lethal irradiation.

IL - 6 has been shown to be involved in diverse physiological processes such as T - cell activation, induction of immunoglobulin secretion, initiation of hepatic acute phase protein synthesis, and stimulation of hematopoietic precursor cell proliferation and differentiation.

Here, ES cells transduced with HOXB4 were analyzed for the expression of hematopoietic markers after 26 days of differentiation.

Allogeneic cells, particularly mismatched or haploidentical cells, in the context of hematopoietic transplantation have been found to provide potent immune surveillance for both hematologic and solid tumor malignancies in a process referred to as graft - versus - tumor [13]--[15].

Singh, R. P., Franke K., Kalucka J., Mamlouk S., Muschter A., Gembarska A., Grinenko T., Willam C., Naumann R., Anastassiadis K., Stewart A. F., Bornstein S., Chavakis T., Breier G., Waskow C., and Wielockx B. HIF - prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady - state and stress.

A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal - bone marrow: a simple and rapid method for the isolation of mouse central bone marrow.

RIG - G gene expression can be induced not only by ATRA along with the differentiation of NB4 cells but also by IFNα in a series of hematopoietic cell lines as well as various types of solid carcinoma cells (1, 3), which pointed to a possible role of RIG - G in signal cross-talk between ATRA and IFNα.

Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation.

Gentner B, Visigalli I, Hiramatsu H, Lechman E, Ungari S, Giustacchini A, Schira G, Amendola M, Quattrini A, Martino S, Orlacchio A, Dick JE, Biffi A, Naldini L. Identification of hematopoietic stem cell - specific miRNAs enables gene therapy of globoid cell leukodystrophy.

Additional in vitro and in vivo studies are needed to determine the cause of the specificity of JAK2V617F for myeloid diseases, as second mutations, host modifiers, differential cytokine receptor expression, and other factors may influence the ultimate phenotype of hematopoietic progenitors that acquire the JAK2V617F mutation.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Patients who receive HSCT receive high doses of chemotherapy, with or without radiation, followed by infusion of hematopoietic stem cells (HSCs)-- rare cells that reside within the bone marrow and are capable of producing all varieties of blood cells.

Functional rescue of dopaminergic neuron loss in Parkinson's disease mice after transplantation of hematopoietic stem and progenitor cells, EBioMedicine, in press.

The growth or production of hematopoietic stem cells (stem cells that give rise to all blood cell types) is known...

Role of hematopoietic stem cells in steady state hematopoiesis It is remain not very clear if all blood cell types are developed from one hematopoietic stem cell (HSC) in normal hematopoiesis, because of limitations of conventional transplantation models.

Title: Cellular aging leads to functional heterogeneity of hematopoietic stem cells - A modelling perspective Authors: Glauche I, Thielecke L, Roeder I Date: March 2011 Publication Details: Aging Cell.

This is why transplants of HSCs (from bone marrow) are also used to treat cancers of the hematopoietic (blood) system, such as leukemia or lymphoma.

Human MSCs are defined by positive expression of the cell surface antigens CD73, CD90, CD105 and by absence of expression of hematopoietic antigens, including CD11b or CD14, CD34, CD45, CD79 or CD19, and HLA - DR.

The aim of the meeting is to bring together recognised experts and outstanding young team leaders around the central theme of hematopoietic stem cells (HSCs) production and regulation throughout life...

HIV gene therapy hopes to confer HIV ‐ resistance to patients through the genetic manipulation of hematopoietic stem / progenitor cells (HSPCs)[1, 2].

Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D, Waskow C. CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.

Title: On the symmetry of siblings: automated single - cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup Authors: Scherf N, Franke K, Glauche I, Kurth I, Bornhauser M, Werner C, Pompe T, Roeder I Date: 2012 Publication Details: Exp Hematol.

Proliferation Drives Aging - Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

While human cord blood represents a potentially important source of hematopoietic stem and progenitor cells (HSPC), current two dimensional (2D) growth conditions employed to amplify cell numbers to the level required for many regenerative applications lead to a decline in the absolute percentage of the most primitive HSPCs [1].

The role of hematopoietic stem cell transplantation in treatment of hemophagocytic lymphohistiocytosis.

Before coming to Columbia she worked as a technician in Leonard Zon's lab at Harvard Medical School using zebrafish as a model for investigating the molecular mechanisms of hematopoietic stem cell differentiation and self renewal.

The FLT3 - signaling pathway controls cell proliferation and survival, particularly of hematopoietic progenitor cells.

Scherf N, Franke K, Glauche I, Kurth I, Bornhäuser M, Werner C, Pompe T, Roeder I On the symmetry of siblings: automated single - cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup.

A major focus is the characterization of homing of hematopoietic stem cells to specific niches from which they can be mobilized or start differentiating.

Regina Duryagina (Bornhäuser, TUD)-- «Role of Jagged - 1 and extracellular matrix components for the maintenance of hematopoietic stem and progenitor cells during ex-vivo expansion» (2013)

Bone marrow CD169 + macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.

This new knowledge has paved the way for the therapeutic transfer of stem cells not only for the treatment of hematopoietic diseases by bone marrow transplantation â $» first attempted by E. Donnall Thomas, one of this bookâ $ ™ s editors, in 1957 â $» but also for the treatment of many other disorders.

This has resulted in the FDA approval of the first CXCR4 antagonist, plerixafor (1) for the mobilization of hematopoietic stem cells (Figure 4)[54].

One chapter describes the clear clinical applications of hematopoietic stem cells from cord blood.

New insights into the cell biology of hematopoietic progenitors by studying prominin - 1 (CD133).

Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells.

«On the symmetry of siblings: automated single - cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup» is featured on the February issue cover.