Sentences with phrase «of higher mutation»

However, the enzyme isn't something that acts once — it is chronically elevated along with HPV infection, leading to years or decades of higher mutation rates.

Yet, this is unlikely to succeed because of the high mutation rate of this virus.

Not exact matches

Eventually, as a result of chance mutations in DNA, accidental modifications subjected to the pressure of natural selection, there emerge the «higher» animals and, at last, man.

Most importantly, while I do agree that common descent is supported by the bulk of the evidence (although admittedly there are difficulties at higher phylogenetic levels), I certainly do not think we have any reason to suppose the process occurred by random mutation and natural selection, the position Prof. Arnhart attributes to me.

your video (apparently done by some high school kid) is self refuting, it's premise is that — mutations exist in a population, — drastic environmental change dramatically favors one set of mutations — this natural selection is then what results in «rapid change»

@ED The only thing that is assumed to be at least more or less constant in evolutionary theory is the mutation rate of individual genes, and even that, since mutations are known, eg, to increase under higher radiation, is only true «on average, over the long run».

These provide material for inter-group selection at a level, the interaction system, higher than that provided for by mass selection of individual mutations.

As a cooking oil, its chemical structure is kept in tact and therefore is resistant to mutations of fatty acid chains even when used in higher cooking temperatures, unlike most vegetable oils.

In his research on a group of families in Pakistan that have a higher risk of deafness, Dr. Ahmed has found that about 8 to 9 percent seem to have mutations in CIB2.

A few studies show an effect on DNA mutations which might explain a higher rate of miscarriage, pregnancy loss and birth defect.

(1) These regulatory thresholds reflect a decline in sperm quality with age and the greater likelihood of DNA mutations and higher risk of genetic abnormality in offspring.

An expanded analysis of colorectal cancer sequences in The Cancer Genome Atlas database showed a high incidence of YME1L1 mutations.

In a 2009 study, Rodriguez found that in people, the mutation in the SCARB1 gene was associated with both higher levels of HDL and diminished amounts of the SRB1 protein.

Annabelle Rodriguez studies gene mutations that can lead to increased risk of heart disease, even in people with high HDL levels.

In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.

The authors searched for genetic mutations that might explain the disproportionately high risk of SUDEP in people with poorly controlled focal epilepsy, which, by definition stems from a specific area of the brain.

Illustration of points in an arbitrary high - dimensional space that live close to a one - dimensional, tree - like structure, as might arise from genomes generated by mutation and selection in evolution.

Single and triple mutants correspond to «x,» and unmutated, double and four - tuple mutants correspond to «y.» The odd number of mutations produce «x» and even numbers produce «y.» The mutants in the order are ranked from high to low fitness.

«There was an unexpectedly high level of HPV16 isolate diversity among women, which was surprising given the fact that the HPV16 genome replicates use the host cell machinery and has a slow mutation rate,» Mirabello says.

«We found that Amish people with this mutation have defects in fat storage, increased fat in the liver, high triglycerides, low «good» (HDL) cholesterol, insulin resistance and increased risk of developing type 2 diabetes,» says the study's senior author, Coleen M. Damcott, Ph.D., an assistant professor of medicine in the Division of Endocrinology, Diabetes and Nutrition and member of the Program for Personalized and Genomic Medicine at the University of Maryland School of Medicine.

«Taken together, our results suggest that SCN8A mutations in people with early - infantile epileptic encephalopathy may increase the risk of SUDEP by creating an environment in which the heart has a higher susceptibility to arrhythmias,» explains author Chad Frasier, Ph.D., a postdoctoral researcher at the University of Michigan.

The mutation is less common in non-Amish Caucasians of European descent (0.2 %), thus the higher prevalence of the mutation in the Amish makes it possible to characterize its full range of effects.

Those with two copies of a mutation in the NRG1 gene, linked to psychosis, scored higher on creativity than volunteers with one or no copies of the mutation (Psychological Science, DOI: 10.1111/j.1467-9280.2009.02398.x).

Gliomas occurring in the spinal cord and thalamus of children also exhibit the H3K27M mutation and were found to similarly express very high levels of GD2.

In fact, the odds of a beneficial mutation occurring are higher than you might think.

«The type of inflammation seen in psoriasis is known to promote insulin resistance, and psoriasis and diabetes share similar genetic mutations suggesting a biological basis for the connection between the two conditions we found in our study,» said the study's senior author Joel M. Gelfand, MD MSCE, a professor of Dermatology and Epidemiology at Penn. «We know psoriasis is linked to higher rates of diabetes, but this is the first study to specifically examine how the severity of the disease affects a patient's risk.»

Going back to the other sequenced genomes, the researchers were then able to show that persons who carry only one copy of the SCARB1 P376L mutation have significantly higher HDL - C levels.

The clinic monitors people who are already at high risk of pancreatic cancer due to family history or having known risk - raising genetic mutations.

One recent study of the E. coli gut bacterium puts the rate as high as 1 beneficial mutation for every 10,000 new bacteria.

The researchers studied whether family members who have not inherited the mutation have any higher than normal risk of developing melanoma or other cancers.

ALD, for instance, is caused by mutations in a gene called ABCD1, leading to unusually high levels of a type of fatty acid that damages the material insulating some neurons.

Previous studies have shown that people with the mutation who also have certain pigmentation variants run an even higher risk of melanoma.

When they put these monitor cells into mice, those that were in mice that had been provoked to have higher levels of inflammation logged more mutations (bioRxiv, doi.org/bhzv).

In the case of head and neck squamous cell carcinoma, for example, high stemness indices correlated with mutations in the gene NSD1.

According to the paper, this is one of the first times an oral biologic has been used successfully to change the natural history of a genetic disease; in this case, a mutation that puts individuals at very high risk for colon cancer.

So the result of the FTO mutations is a drive to eat higher - calorie foods paired with less calorie burning and more calorie hoarding — a challenging combination for any dieter.

ETH researchers have now shown that the high estimated mutation rates at the start of the epidemic were due to the limited number of virus samples at the time in combination with the computer models used, which calculate the estimates using genetic data from virus samples and from underlying assumptions.

People with specific mutations in the CARD14 gene have a high probability of developing psoriasis.

Given the cities» historical trade networks, researchers believe that this high incidence of the normally rare mutation resulted from a few polydactyl merchant - ship cats taking shore leave as far back as the mid-18th century.

For some cancer types the researchers found that a high stemness index was associated with the presence of mutations.

«We believe that individuals born with this genetic mutation and who are later exposed to MAP through consuming contaminated milk or meat from infected cattle are at a higher risk of developing rheumatoid arthritis,» Naser said.

Using high - throughput DNA sequencing, the researchers located mutations in bacterial genes that resisted the toxicity of growth inhibitors produced by bacterial viruses.

Under the new recommendations, the parents would learn not only if their child's heart condition is due to a particular gene mutation — they'd also learn whether she is at high risk of certain breast cancers, colon cancers, cardiomyopathies, aneurysms, and other diseases.

The approach is already routine for some cancer patients, such as women and men with breast cancer tumors that have high levels of a protein called HER2, or lung cancer tumors with mutations in the EGFR gene.

The ACMG working group limited its list to genes that carry a high risk of disease — for example, mutations in BRCA1 and BRCA2, which significantly raise the risk of breast and ovarian cancer, and for which extra screening and prophylactic surgery can reduce risk.

«Based on mutations we found in the genome, there is evidence of high levels of oxidative stress in the tumors,» Dyer said.

Ashkenazi Jewish women with a family history of breast cancer may have a disease risk as high as 90 % or more if they carry mutations in BRCA1; another woman with no family history may have a much lower risk.

Michele Carbone and colleagues, from the University of Hawaii, discovered that members of 4 families, apparently unrelated and living in different US States, shared the identical mutation of a gene called BAP1 that is associated with a higher incidence of mesothelioma, melanoma, renal carcinoma and other cancers.

Next, the investigators compared the SBA mutations with mutations in the two other parts of the GI tract and found higher and lower mutation frequencies across a wide array of genes.

To find BRCA mutations — which are very rare — most studies have examined families with very high rates of breast and other cancer in young family members.