Sentences with phrase «of homologous recombination»

Caris performed the molecular profiling on 48,733 solid tumor samples to assess the prevalence of homologous recombination deficiency in about 20 different types of solid tumors.

«With ongoing studies of the homologous recombination pathway and its impact on cancer development, we may identify additional genes that, when mutated, allow for either improved response to specific treatments or conversely, portend more aggressive tumor biology, and this could greatly inform development of new cancer therapies,» Heeke explains.

Cancer Network: What are the ways to test for this deficiency of homologous recombination in patients with ovarian cancer?

They trick cells into treating the added DNA as its own, greatly increasing the chance of homologous recombination.

The plants survived the ordeal by upping the frequency of homologous recombination (genetic swapping) during cell division as expected.

Eric Greene, PhD, Biochemistry & Molecular Biophysics, will receive $ 738,876 over five years from the Wellcome Trust for «Mechanics and Execution of Homologous Recombination — Biophysics to the Organism.»

If you look at the most clear indication of homologous recombination deficiency — loss of BRCA1 or BRCA2 cancer genes, either in the inherited germline or the tumor itself — that number is close to 25 % of ovarian cancers.

Axel Erler (Stewart, TUD)-- «Family ties: characterization of DNA annealing protein reveal a new model or the initiation of homologous recombination» (2008)

That will require a completely new set of clinical trials, and it's my expectation that the benefit is going to be most marked in those individuals with clear evidence of homologous recombination deficiency.

The work of the Homologous Recombination and Cancer team describes a novel DNA...

Our laboratory is particularly interested in studying alternative DNA repair mechanisms, such as the alternative end joining (alt - EJ) pathway, that take place in cancer cells to compensate for the loss of homologous recombination (HR) activity (Figure 2A).

Abstract SY28 - 02: Connections in the BRCA1 - BRCA2 pathway of homologous recombination: Implications for breast cancer development and treatment