Sentences with phrase «of homozygosity»

The Bouvier des Flandres is a breed which exhibits a relatively high level of homozygosity due to inbreeding and numerous inherited disorders are believed to have risen in prevalence as a result [25].

Absence or reduced heterozygosity means that a patient's genome contains long stretches of homozygosity, which can be problematic if that region harbors a variant in an autosomal recessive disease gene.

We demonstrate an excess of homozygosity and rare protein - coding variants in Iceland.

The coefficient of inbreeding is an equation which expresses the expected percentage of homozygosity arising from a given Sire and Dam, meaning, the probability of how genetically similar they are.

The block of homozygosity was not observed in controls except for one dog (dog number 17 in Appendix 1).

Moreover, there was a high level of homozygosity among the dominant DLA class I (19 %) and II (42 %) haplotypes.

Ten English bulldogs and 10 Standard Poodles were randomly selected and their SNP arrays interrogated for runs of homozygosity (ROH) using PLINK [30].

This study examines genetic diversity among 102 registered English Bulldogs used for breeding based on maternal and paternal haplotypes, allele frequencies in 33 highly polymorphic short tandem repeat (STR) loci on 25 chromosomes, STR - linked dog leukocyte antigen (DLA) class I and II haplotypes, and the number and size of genome - wide runs of homozygosity (ROH) determined from high density SNP arrays.