Sentences with phrase «of human and mouse»

267/4: 30 Extremely high resolution 3D maps of human and mouse genomes across lineages and during differentiation reveal principles of chromatin looping.

Liquid chromatography - mass spectrometry - based parallel metabolic profiling of human and mouse serum reveals putative biomarkers with the progression of nonalcoholic fatty liver diseases.

About half of the sequence of the human and mouse genomes is derived from these mobile elements.

For custom gene expression projects the Genomics Core has a platform that uses sets of human and mouse custom arrays whose probe content is aimed at gene expression studies in the areas of cancer, immunology and other complex diseases.

Genetic profiles of human and mouse cells have now been posted on the Human Cell Atlas online portal.

A proprietary bioinformatics tool for the detection of aging biomarkers in DNA samples from somatic cells of human and mouse;

If the genome projects verify the underlying octoploid nature of the human and mouse genomes, then the basic vertebrate gene number may be similar to that of the fly and worm, about 12,000 to 14,000 genes.

The team designed the PshRNA agent selectively targeting the common sequence of human and mouse (pro) renin receptor genes.

A team of postdoctoral and research scientists at the Wellcome Sanger Institute and MRC Cancer Unit has made data sets of human and mouse immune and stromal cells openly accessible on a preview site that provides initial access to data for the Human Cell Atlas initiative, before these have been published.

To overcome this, researchers from the University of Texas Southwestern Medical Center and Johns Hopkins University stabilized pri - miRNAs by expressing a dominant negative form of DROSHA, the RNase III enzyme responsible for pri - miRNA cleavage, in a variety of human and mouse cell lines.

In today's Cell, researchers report that the DNA on the end of human and mouse chromosomes forms a loop, with the exposed end tucked back into the DNA strand.

UCLA scientists, in collaboration with teams in China, have used the powerful technology of single - cell RNA sequencing to track the genetic development of a human and a mouse embryo at an unprecedented level of accuracy.

Anatomical examination of human and mouse eyes was used to determine the effect of the laser on the sensitive light - detecting retina.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Scientists poring over the 3 - billion - letter - long genomes of humans and mice made a host of new discoveries in 2005.

Looking across evolutionary time and the genomic landscapes of humans and mice, an international group of researchers has found powerful clues to why certain processes and systems in the mouse — such as the immune system, metabolism and stress response — are so different from those in people.

The germ cells made from stem cells stopped differentiating in the mice before they produced mature sperm (likely because of the significant differences between the reproductive processes of humans and mice) regardless of the fertility status of the men from whom they were derived.

Here we show that T cells that express the canonical hValpha7.2 - Jalpha33 or mValpha19 - Jalpha33 TCR rearrangement are preferentially located in the gut lamina propria of humans and mice, respectively, and are therefore genuine mucosal - associated invariant T (MAIT) cells.

While the genomes of two humans may only vary by 0.1 %, two strains of the same bacteria can differ by more than 50 % — greater than the disparity between the genomes of humans and mice.

Not exact matches

Studies have found that the additive increases risk of certain types of cancer in mice and the International Agency for Research on Cancer classifies byproduct 4 - Mel as «possibly carcinogenic to humans.»

Yesterday's ruling effectively said that Feng Zhang's adoption of the technique in human and mouse cells was, in fact, a new and patentable invention rather than an «obvious» extension of Doudna's and Charpentier's work.

«There's no mouse model and no human model of the ideas,» she said.

Hoping to learn something about how the human body defends itself against cancer, he had zeroed in on a complex regiment of lymphocytes called T cells, common to the immune systems in both mouse and man.

Currently SQZ is developing its technology further using mouse models and human blood experiments to understand its mechanisms of action more fully.

Humans are not sterile mice, after all, and we all start with our own unique mix of bacteria swirling around.

a comment for you, a ufo picture who the fbi acredired as a real.pedrfo castillo who was teh one that sent me that noticie, i just did no much as put my mouse on that such an ufo, and sudendly something so i called part of human appeard.

It might mean - and most of the public attention has taken it to mean - an attempt to clone, gestate, and bring to term a human being, to do for human beings what has already been done for mice and for the lamb «Dolly.»

Of course, there is still a long way to go before this particular method will be tested on humans (it was tested on mice), and an even longer way to go before it'll be used in medical therapies (if it ever will translate into therapies), but one thing is becoming clear: We need not compromise our moral principles and rush into government - funded embryo - destructive research.

The researchers used specially born and raised mice having no gut microbes of their own, that then receive a transplant of 14 bacteria that normally grow in the human gut.

In order to determine the lethal toxic level of capsaicinoids in animals, and to extrapolate that level for humans, researchers in 1980 performed a rather gruesome experiment with mice, rats, guinea pigs and rabbits.

Hassles such as buying paper towels or searching for the perfect used car that used to require legwork, human interaction, and possibly even wearing pants can now be done with a click of a mouse from one's own living room.

The team found neonatal mice with the mutations had normal - appearing skin, and the dry itchy skin of dermatitis did not develop until the mice were a few months old, the equivalent of a young adult in human years.

This region has the highest oxytocin levels in the brain and has high levels of oxytocin receptors across all species from mice to humans.

As part of the study, researchers found that mice engineered to develop symptoms of human inflammatory disease, and which also lacked the ATG16L1 gene, developed gut damage.

Much of their work focuses on the house mouse (Mus musculus), which evolved to be commensal with humans: The mice are not domesticated like dogs or sheep, but they are dependent on living in and around a human settlement.

Compared with mice with cells from healthy people as well as non-chimera mice, those whose brains had human schizophrenia cells were more afraid to explore a maze, more anxious, more antisocial, less able to feel pleasure (from sipping sugar water), worse at remembering, and more sleepless — all of which characterize people with schizophrenia, too.

Now, a new study of wild mice shows that they, too, can develop signs of domestication — white fur patches and short snouts — with hardly any human influence.

Dr. Issa's team made their discovery after first examining methylation patterns on DNA in blood collected from individuals of different ages for each of three species — mouse, monkey, and human.

A study by researchers at the University of Chicago Medicine shows that when mice that are genetically susceptible to developing inflammatory bowel disease (IBD) were given antibiotics during late pregnancy and the early nursing period, their offspring were more likely to develop an inflammatory condition of the colon that resembles human IBD.

«We don't know if the observed reversibility of the disease symptoms as observed in the mouse,» he says, «exists in humans who have a much longer period of pre - and post-natal brain development than mice — months and years in humans, weeks in mice.»

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

The Salk team therefore took human brain organoids that had been growing in lab dishes for 31 to 50 days and implanted them into mouse brains (more than 200 so far) from which they had removed a tiny bit of tissue to make room.

Introducing human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor cells to invade and grow in bone.

The mice behaved just like others of their kind, as far as scientists could tell, and they also looked the same — except for the human mini brain that had been implanted into each rodent's own cortex, made visible by a little clear cover replacing part of their skull.

«Our study shows that epigenetic drift, which is characterized by gains and losses in DNA methylation in the genome over time, occurs more rapidly in mice than in monkeys and more rapidly in monkeys than in humans,» explains Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research at LKSOM, and senior investigator on the new study.

The scent of human men stresses out mice and rats, which changes their pain responses and could affect experimental results.

They seeded mice with human pancreatic tumours and then injected them daily with the souped - up bacteria for a week, giving them a week off before four more days of injections.

Humans and mice share about 97 percent of their genes.

In that paper, Weitzmann, Ofotokun, and their colleagues described bone loss similar to that observed in humans following the reconstitution of the T cell population in immune - compromised mice (similar to T - cell expansion following ART).

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.