FGPs are thought to be important in a variety
of human brain disorders and conditions.
«Horse sickness shares signs
of human brain disorders, study finds.»
Not exact matches
Eric Topol speaks with Edward Boyden about the promise
of optogenetics, from treating common
brain disorders to unlocking what it means to be
human.
Dr. Perry's research includes: the effects
of prenatal drug exposure on
brain development, the neurobiology
of human neuropsychiatric
disorders, the neurophysiology
of traumatic life events, and long - term cognitive, behavioral, emotional, social and physiological effects
of neglect and trauma in children, adolescents and adults.
Professor Jianfeng Feng commented that new technology has made it possible to conduct this trail - blazing study: «
human intelligence is a widely and hotly debated topic and only recently have advanced
brain imaging techniques, such as those used in our current study, given us the opportunity to gain sufficient insights to resolve this and inform developments in artificial intelligence, as well as help establish the basis for understanding and diagnosis
of debilitating
human mental
disorders such as schizophrenia and depression.»
A recent study published in Annals
of Neurology reports that healthy
human tissue grafted to the
brains of patients with Huntington's disease in the hopes
of treating the neurological
disorder also developed signs
of the illness, several years after the graft.
By doing so, members
of Gould's laboratory pinpointed
brain cells and regions important to anxiety regulation that may help scientists better understand and treat
human anxiety
disorders, she said.
«The project's goal is to accelerate the development
of technologies for mapping the
brain's circuitry in animal models, specifically in the marmoset monkey, whose neural circuits are much closer to
human compared with rodent models, and to connect the results to the diagnosis and treatment
of human neurological
disorders and mental illness.»
While mouse models have traditionally been used in studying the genetic
disorder, Deng said the animal model is inadequate because the
human brain is more complicated, and much
of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure
of the
brain as well as in the transmission
of nerve impulses.
If so, it would mean that, rather than being an 18,000 - year - old representative
of a new species, the hobbit was just a modern
human with a growth
disorder that left it with a
brain the size
of a grapefruit, among other odd traits, which is what critics have argued all along.
Jasanoff is critical
of how the cerebral mystique reduces problems
of human behavior, such as drug addiction or eating
disorders, to problems
of the
brain.
A neuroscientist at Rutgers University - Newark says the
human brain operates much the same whether active or at rest — a finding that could provide a better understanding
of schizophrenia, bipolar
disorder and other serious mental health conditions that afflict an estimated 13.6 million Americans.
Prions, whose normal function is unclear, are the likely cause
of mad cow disease and similar
brain disorders in animals and
humans.
«The imaging technique could shed light on the immune dysfunction that underpins a broad range
of neuroinflammatory diseases, such as Alzheimer's disease, depression, post-traumatic stress
disorder and addiction,» said Christine Sandiego, PhD, lead author
of the study and a researcher from the department
of psychiatry at the Yale School
of Medicine in New Haven, Conn. «This is the first
human study that accurately measures this immune response in the
brain.
Additionally, 2013 MRI research from Cummings School
of Veterinary Medicine at Tufts University and McLean Imaging Center at McLean Hospital showed that the structural
brain abnormalities
of Doberman pinschers afflicted with canine compulsive
disorder (CCD) were similar to those
of humans with OCD.
The authors suggest that the intricate balance between the signaling
of neurons in these three
brain regions may be crucial for normal social behavior in
humans, and that disruption may contribute to various psychiatric conditions, including autistic spectrum
disorders.
German and Canadian scientists have built a three dimensional map
of the
human brain to help in the development
of new treatments for neurological
disorders like Alzheimer's and Parkinson's disease.
Brain Institute demonstrates in songbirds the necessity
of this neural circuit to learn vocalizations at a young age, a finding that expands the scientific understanding
of some contributing factors in speech
disorders in
humans.
In a study spanning molecular genetics, stem cells and the sciences
of both
brain and behavior, researchers at University
of California San Diego, with colleagues at the Salk Institute
of Biological Studies and elsewhere, have created a neurodevelopmental model
of a rare genetic
disorder that may provide new insights into the underlying neurobiology
of the
human social
brain.
The letter further contends that recent chimp studies for the first time have identified «unique features
of the
human brain and have documented the unusual vulnerability
of humans to a variety
of disorders, including Alzheimer's disease, infectious diseases, cancer, and heart disease.»
Most modern studies
of bipolar
disorder have concentrated on the
brain's cortex, the largest part
of the
brain in
humans, associated with higher - level thought and action.
Though these findings have been obtained in mice, the scientists hypothesize that disrupted coordination between the development
of the microglia and that
of the
brain contributes to an increased risk
of such neurodevelopmental
disorders as autism and schizophrenia in
human beings.
If the new mechanism also operates in the
human brain and can be potentiated, this could become
of clinical importance not only for stroke patients, but also for replacing neurons which have died, thus restoring function in patients with other
disorders such as Parkinson's disease and Huntington's disease,» says Olle Lindvall, Senior Professor
of Neurology.
The scientists say their study, published in Frontiers
of Neuroscience, opens a pathway to studying bat
brains in order to understand certain
human language
disorders and potentially even improving computer speech recognition.
Dr. Zhu said he believes the study provides the scientific community with an important animal model to further investigate ARID1B's role in
human brain disorders and will be a useful tool for therapeutic testing
of potential treatments for autism, intellectual disability, and Coffin - Siris syndrome.
Working with mouse, fly and
human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement
of cellular materials in and out
of a cell's control center — the nucleus — appear to be a direct cause
of brain cell death in Huntington's disease, an inherited adult neurodegenerative
disorder.
«We can't guess the biology
of human brains and neurodevelopmental
disorders just by studying mouse
brains.»
In the new study, the researchers discovered that during the second trimester
of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric
disorders.
«The method thus opens up completely new opportunities for investigating
disorders in the architecture
of the developing
human brain,» explains Dr. Julia Ladewig, who leads a working group on
brain development.
Developmental
disorders of the
human brain can thus only be resembled to a limited degree in the animal model.
Researchers found that levels
of neurotrophic factor (BDNF) nearly doubled in the
brains of vulnerable mice, a finding that could point to a therapeutic target in
humans for combating post-traumatic stress
disorder and depression.
If the approach also works with
human cells, it could eventually lead to cell therapies for diseases like inherited leukodystrophies —
disorders of the
brain's white matter — and multiple sclerosis, as well as spinal cord injuries.
The results
of their work, the researchers say, may advance scientific understanding
of how genes linked to the risk
of human bipolar
disorder change neuronal circuits in the
brain, and may offer an animal model for testing new treatments.
The test tube finding, reported in the current Cell, could help explain the formation
of prions — the tangled proteins that are implicated in mad cow disease and several
human brain disorders — and eventually may lead to a way to smooth out these rogue proteins.
This information is used to understand the role
of electrical function in
human brain disorders.
In a first -
of - its - kind effort to illuminate the biochemical impact
of trauma, researchers at NYU Langone Medical Center have discovered a connection between the quantity
of cannabinoid receptors in the
human brain, known as CB1 receptors, and post-traumatic stress
disorder, the chronic, disabling condition that can plague trauma victims with flashbacks, nightmares and emotional instability.
A recent
human study also indicated a genetic association
of the αCaMKII gene with bipolar
disorder, and decreased expression
of αCaMKII has been observed in postmortem
brains of patients with bipolar
disorder.
These so - called bioreactors, and the mini-brains they foster, should open other new and valuable windows into
human brain development,
brain disorders and drug testing — and perhaps even produce neurons for treatment
of Parkinson's disease and other
disorders, the investigators say.
«This is the first instance I am aware
of where an academic drug discovery group moved a molecule designed to hopefully treat a chronic
brain disorder all the way from early discovery to
human trials without there being, at some point along the way, a pharmaceutical partner,» said P. Jeffrey Conn, Ph.D., Lee E. Limbird Professor
of Pharmacology in the Vanderbilt University School
of Medicine and director
of the Vanderbilt Center for Neuroscience Drug Discovery (VCNDD).
Mice inserted with a rare
human genetic variation in the dopamine transporter could lead to improvements in the diagnosis and treatment
of brain disorders.
The transgenic mouse, into which was inserted a rare
human genetic variation in the dopamine transporter (DAT), could lead to improvements in the diagnosis and treatment
of these all - too - common
brain disorders, said Randy Blakely, Ph.D., the report's senior author.
On the negative side, the researchers found that many
of the genes whose activity is unique to modern
humans are linked to diseases like Alzheimer's disease, autism and schizophrenia, suggesting that these recent changes in our
brain may underlie some
of the psychiatric
disorders that are so common in
humans today.
Brain disorders represent an enormous burden on society in terms
of human suffering and economic cost.
Its mission is to provide a resource for researchers studying the
human brain and the neurobiological causes
of brain disorders.
From the bakery to the
brain business: developing inducible yeast models
of human neurodegenerative
disorders.
Now researchers at UC San Francisco have taken the first step toward a comprehensive atlas
of gene expression in cells across the developing
human brain, making available new insights into how specific cells and gene networks contribute to building this most complex
of organs, and serving as a resource for researchers around the world to study the interplay between these genetic programs and neurodevelopmental
disorders such as autism, intellectual disability and schizophrenia.
The
brains of aging
humans are prone to neurodegenerative
disorders and we are unable to counteract neuronal loss by regenerating lost cells.
From MIT Tech Review: «A new method for growing
human brain cells could unlock the mysteries
of dementia, mental illness, and other neurological
disorders.»
Developing zebrafish models
of complex phenotypes relevant to
human brain disorders.
Human genetic studies strongly point to apolipoprotein E (APOE) and microglia (the immune cells
of the
brain) as, respectively, the most important gene and cell type in the chain
of events leading to Alzheimer's disease (AD), a common
disorder in the elderly in which the
brain is damaged and memories falter.