Sentences with phrase «of human breast cancer»

In one study, pomegranate extract was found to inhibit the growth of human breast cancer cells by inducing cell death.

Scientists have routinely used mice to replicate aspects of human breast cancer in an effort to find a cure to the most common type of cancer among women.

This is an environmental estrogen that activates the increased production of human breast cancer cells.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

Their study, published in the ACS journal Chemical Research in Toxicology, found that triclosan, as well as another commercial substance called octylphenol, promoted the growth of human breast cancer cells in lab dishes and breast cancer tumors in mice.

Furthermore, expression of a degradation - resistant RAPGEF2 mutant greatly suppresses dissemination and metastasis of human breast cancer cells.

Finally, an additional study conducted at Johns Hopkins University supported the ability of sulforaphane in broccoli sprouts to inhibit the growth of four different types of human breast cancer cells — a truly encouraging result.

Through these effects, the PERY peptide reduced the proliferation of several (but not all) cancer cell lines in culture and inhibited the growth of a human breast cancer xenograft in mice.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

Human epidermal growth factor receptor 2 (HER2) is upregulated in a subset of human breast cancers.

«We found that the vast majority of human breast cancers can be represented by one of the strains we studied,» Andrechek said.

Singletary added sulforaphane, a chemical in broccoli, kale, brussels sprouts, and other cruciferous vegetables, to cultures of human breast cancer cells.

Some experts have traced estrogen - like chemicals to increased rates of human breast cancer, and there is even more evidence that they endanger animals by feminizing the sex organs of male frogs and fish living downstream from sewage treatment plants.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

Though unproven and hotly debated, the theory remains intriguing because known cancer - causing genes such as BRCA - 1 explain only a percentage of human breast cancer cases, and because viruses do cause other forms of cancer in humans and animals.

** Marcia, F.E. Godinho et al., Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer, British Journal of Cancer (2010)

Dr. Jos Jonkers» research group studies the genetic basis of human breast cancer, using advanced mouse models for p53 - induced breast cancer, BRCA1 - and BRCA2 - associated hereditary breast cancer, and E-cadherin mutated invasive lobular carcinoma.

We also found that S1P levels are high in breast cancer compared from the surrounding normal breast tissue (Nagahashi M et al, Journal of Surgical Research 2016) that associate with sphingosine kinase 1 activity of human breast cancer (Tsuchida J et al, Journal of Surgical Research 2016).

An Improved Syngeneic Orthotopic Murine Model of Human Breast Cancer Progression Breast Cancer Research and Treatment 2014 Oct; 147 (3): 501 - 12.

The project focuses on the study of human breast cancer cells, particularly if and how CNPs can target and deliver medication to specific cells.

Thank you for sending your work entitled «miR - 142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway» for consideration at eLife.

To evaluate the role of miR - 142 in the growth of human breast cancers initiated by the human BCSCs, we infected human BCSCs isolated from a patient - derived human breast cancer xenograft (PDX) with the anti-miR-142-3p-expressing lentivirus or the control lentivirus.

We further confirmed that consistent with the results of the human breast cancer cell lines (Figure 2), the protein level of APC was elevated in the human breast cancer cells isolated from the anti-miR-142-3p-expressing breast cancer xenograft (Figure 7B).

These observations suggest that in addition to LOH, promoter methylation, and the APC mutations, miRNAs that target APC may regulate the aberrant activation of the canonical WNT signaling pathway for the initiation of human breast cancers, the enhancement of niche independence, and the aberrant proliferation of the human BCSCs.

For the study, mice having a highly aggressive type of human breast cancer known as HER - 2 were fed the different kinds of omega - 3s.

In the video I profile a study from the University of Wisconsin, where researchers pitted two lines of human prostate cancer and two of human breast cancer against the peels of organic gala apples.

Recent collaborative work between UCR and Cedars - Sinai Medical Center in Los Angeles demonstrated that in animal models of human breast cancer, mice treated with 123B9 that was conjugated with paclitaxel had significantly fewer circulating cancer cells in the blood compared to mice that were not treated or even treated with paclitaxel alone.

Curcumin suppresses the paclitaxel - induced nuclear factor - kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice.

The growth of the human breast cancer xenografts formed by the anti-miR-142-3p-expressing BCSCs was significantly slower than that of the control human breast cancer xenografts (Figure 7A).

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

So it came as a shock when researchers at the University of Minnesota published a study showing that doses of morphine similar to those used to ease pain actually spurred the growth of human breast cancer cells grafted into mice.

«This confirmed hnRNPM's role in the metastasis of human breast cancer,» Cheng said.

Berkeley Lab researchers have developed the first clinically - relevant mouse model of human breast cancer to successfully express functional estrogen receptor positive adenocarcinomas.

A major focus of their current cancer research is using animal, cell - based, molecular, and biophysical approaches to investigate the role of HIF - 1 in vascular and lymphatic metastasis of human breast cancer.

In a paper published February 3 in Cell Stem Cell, the scientists report striking similarities between genetic signatures found in certain types of human breast cancer and those of stem cells in breast tissue in mouse embryos.

The method, now universally known as the «Huggins tumor,» quickly became the most intensely investigated laboratory animal model of human breast cancer.

In 1961, Dr. Huggins developed an experimental model of human breast cancer, the lack of which had been a major obstacle to research.

Excessive proliferation of human breast cancer cells is never good, so countries in Europe started banning and restricting the use of these chemicals.

A study conducted at the University of California at Santa Barbara found that sulforaphane inhibited the growth of human breast cancer cells, causing researchers to praise it is a «promising» protective agent against breast cancer.