Not exact matches
Some
of the viruses that can be within
breast milk are: HIV —
Human Immunodeficiency Virus (AIDS) HTLV - 1
Human T -
Cell Leukemia Virus Type I CMV — Cytomegalovirus When you are using a previously owned
breast pump you create the risk
of cross contamination.
For a long time, insulin was not thought to play a direct role in regulating the milk - making
cells of the
human breast, because insulin is not needed for these
cells to take in sugars, such as glucose.
Breastfeeding is contraindicated in infants with classic galactosemia (galactose 1 - phosphate uridyltransferase deficiency) 103; mothers who have active untreated tuberculosis disease or are
human T -
cell lymphotropic virus type I — or II — positive104, 105; mothers who are receiving diagnostic or therapeutic radioactive isotopes or have had exposure to radioactive materials (for as long as there is radioactivity in the milk) 106 — 108; mothers who are receiving antimetabolites or chemotherapeutic agents or a small number
of other medications until they clear the milk109, 110; mothers who are using drugs
of abuse («street drugs»); and mothers who have herpes simplex lesions on a
breast (infant may feed from other
breast if clear
of lesions).
Colostrum contains high concentrations
of secretory IgA, the predominant immunoglobulin passed through your
breast milk, lactoferrin, which acts as an antibacterial to prevent infection in
human infants, and leukocytes, protective white
cells.
In November 2010 Japanese researchers announced online in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and
breast cancer
cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings
of the National Academy
of Sciences USA developed a microscale replica
of the
human liver that allowed them to observe the entire life cycle
of hepatitis C, a virus that is difficult to observe in cultured
cells.
Recent collaborative work between UCR and Cedars - Sinai Medical Center in Los Angeles demonstrated that in animal models
of human breast cancer, mice treated with 123B9 that was conjugated with paclitaxel had significantly fewer circulating cancer
cells in the blood compared to mice that were not treated or even treated with paclitaxel alone.
Working with
human breast tissue, the new study's authors attempted to induce EMT in normal
cells; they figured they would just get fibroblasts, a type
of connective tissue that is important in wound healing.
Stem
cells from
breast milk can grow into many other kinds
of human tissue, raising hopes
of an ethical source
of embryonic - like stem
cells
An unknown component
of breast milk appears to kill HIV particles and virus - infected
cells, as well as blocking HIV transmission in mice with a
human immune system.
In their latest study, they tested compounds against
cells from nine different types
of human cancer, including common types affecting blood, colon,
breast, prostate, ovaries, kidneys, and lungs.
Bloch's colleagues at the National Institute
of Environmental Health Sciences tested the oils in gene expression studies on lab - grown
human breast cancer
cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.
If further research confirms the findings in
human cells, limiting the amount
of asparagine cancer patients ingest could be a potential strategy to augment existing therapies and to prevent the spread
of breast cancer, Knott added.
Pre-clinical studies have shown it to be effective in eliminating a number
of different kinds
of cancers
cells, including cancer stem
cells from
human breast cancer patient biopsies.
The researchers observed the effect
of the synthetically produced molecule, JK - 31, on the growth and proliferation
of a model
human breast cancer
cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process
of the division
of cancer
cells, and therefore inhibited the proliferation
of the
cells.
Oncologists William Hahn, Robert Weinberg, and colleagues at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, mutated the gene for one part
of the enzyme and inserted it into cultured
human cells from colon, ovary, and
breast tumors.
Moreover, epalrestat, a drug that inhibits AKR1B1 and is approved in Japan to treat peripheral neuropathies associated with diabetes, was similarly able to block the growth and metastasis
of human basal - like
breast cancer
cells.
Compared to a control (left), epalrestat treatment (right) reduces the number
of metastatic tumors (arrowheads) in the lungs
of mice injected with
human basal - like
breast cancer
cells.
Beyond lung cancer, TiY is able to target TICs in 28 types
of human cell lines derived from the central nervous system, melanoma,
breast, renal, ovarian, colon, and prostate cancer.
To see whether cancer stem
cell renewal involves a chain
of events similar to that used by embryonic stem
cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two
human breast cancer
cell lines that responded to low oxygen by ramping up production
of the protein ALKBH5, which removes methyl groups from mRNAs.
Working with
human breast cancer
cells and mouse models
of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer
cells to migrate and invade other organs.
«There are still many questions left to answer but we now know that oxygen poor environments, like those often found in advanced
human breast cancers serve as nurseries for the birth
of cancer stem
cells,» says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor
of Medicine and a member
of the Johns Hopkins Kimmel Cancer Center.
Through these effects, the PERY peptide reduced the proliferation
of several (but not all) cancer
cell lines in culture and inhibited the growth
of a
human breast cancer xenograft in mice.
Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy
of this kind
of drug candidates against cancer stem
cells, and the possibility
of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective
of their possible application for the treatment
of human breast cancer.
In earlier studies involving animal models and
human cancer
cell lines, researchers found that
breast cancer spreads when three specific
cells are in direct contact: an endothelial
cell (a type
of cell that lines the blood vessels), a perivascular macrophage (a type
of immune
cell found near blood vessels), and a tumor
cell that produces high levels
of Mena, a protein that enhances a cancer
cell's ability to spread.
Lead author Moustafa Abdalla writes: «Almost all genomic studies
of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in
human breast epithelial
cells.»
To test this idea, the researchers utilized two mouse models
of human breast cancer metastasis and found dormant disseminated tumor
cells residing upon the membrane microvasculature
of lung, bone marrow and brain tissue.
One
of these, UJ3, is as effective as the industry - standard drug Cisplatin in killing cancer
cells in laboratory tests done on
human esophageal cancer,
breast cancer and melanoma.
In this study, the researchers tested the effects
of Olaparib on the tumors formed by
human breast cancer
cells injected into mice.
The resulting «map»
of gene - drug interactions allowed the researchers to accurately predict the responses
of multiple
human cancer
cell lines to different chemotherapy agents based on the
cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response
of breast and ovarian tumor
cells to common classes
of chemotherapy treatment.
He is researching the functions and properties
of human sulfotransferase (EST) enzymes in
human breast cancer
cell lines.
Their study, published in the ACS journal Chemical Research in Toxicology, found that triclosan, as well as another commercial substance called octylphenol, promoted the growth
of human breast cancer
cells in lab dishes and
breast cancer tumors in mice.
Bottom:
Human epithelial
cells from
breast tissue showing the effects
of endoplasmic reticulum stress (blue) which fills the entire
cell structure.
«If further studies validate that these processes are critical in
human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties
of the extracellular matrix, or that target the receptors and signaling molecules associated with how
cells sense this matrix, could be used as a new avenue for the prevention or treatment
of breast cancers.»
However, scientists at SFU, the University
of British Columbia and the B.C. Cancer Agency have discovered that many non-coding RNAs are perturbed in cancerous
human cells, including
breast and lung, in a specific way.
Singletary added sulforaphane, a chemical in broccoli, kale, brussels sprouts, and other cruciferous vegetables, to cultures
of human breast cancer
cells.
Their preliminary findings indicate that MUS81 - induced movement
of DNA to the cytosol also occurs in
human cancer
cells, including prostate cancer,
breast cancer, colorectal cancer, uterine cancer, leukemia, and melanoma
cells.
Using cultured
cells derived from
human tumors
of the
breast and prostate gland, they confirmed that the IL6R / STAT3 / miR -34 a feedback loop is also activated in other tumor types.
When the Cornell team cultured
human breast cancer
cells on matrix deposited by fat - derived
cells from obese mice, the cancer
cells grew faster than they did on the matrix
of cells from slimmer mice.
The scientists» model looks at the EGFR signaling cascade to investigate crosstalk between EFGR signaling and EMT in
cell culture models
of human breast epithelium.
They compared normal, non-cancer-forming
human breast tissue
cells with cancerous
breast cells using both
of these treatments, contrasting them with
cells with unmanipulated mtDNA.
After confirming in mouse models that
cells from HER2 - positive
breast cancers became resistant to anti-HER2 treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed in brain metastases
of HER2 - positive
breast cancers from both mice and
human patients.
Now, University
of Pennsylvania researchers have revealed how a reduction in mitochondrial DNA content leads
human breast cancer
cells to take on aggressive, metastatic properties.
The ability
of the ITAM sequence to make
cells cancerous represents a potential new trigger for
breast cancer in
humans, say the researchers, and gives further credence to the idea that viruses can cause
human breast cancer.
The researchers inserted between 10,000 and 40,000
of these small RNAs at once into
breast cancer, colon cancer, and normal
human cells in the lab.
Additionally, overexpression
of POSTN in
human mammary epithelial and
breast cancer
cells resulted in enhanced tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer
cell model where overexpression
of POSTN resulted in an increase in the number and size
of liver metastases (Bao et al., 2004).
Human breast cancer
cells generated by oncogenic transformation
of primary mammary epithelial
cells.
Regulation
of the inflammatory profile
of stromal
cells in
human breast cancer: prominent roles for TNF - a and the NF -?
Mutations in the gene increase rat susceptibility to mammary cancer and FRY reduced the growth
of highly aggressive
human breast cancer
cells.
The analysis
of doxorubicin resistance in
human breast cancer
cells using antibody microarrays.
Further research uncovered a broad spectrum
of cell surface stem
cell markers (e.g., CD133, CD44, and CD24) that allow the identification
of CSCs in
human solid tumors, including brain,
breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).