Historically, to help develop and understand the potential
of human cancer treatments the gold -LSB-...]
Not exact matches
There are currently two types
of cancer vaccines available: preventive, for
human papillomavirus and hepatitis B; and
treatment, for metastatic prostate
cancer.
It will take at least a couple
of years for Theralase Technologies Inc.'s
cancer treatment technology to become regulated (and at least a year before we know how well it works on
humans), but the healthcare tech they have under development is worth talking about.
Those who feel there is something «unnatural» about introducing
human genes into animals or plants forget that we share a high proportion
of our genes with these species already: it is precisely this collective heritage that allows experiments on frogs to spawn
treatments for
human cancer.
Battinus works as a
human resources recruiter with
Cancer Treatment Centers
of America.
Sir John Bell, professor
of medical sciences at Oxford University and government advisor on
human genomics believes this will transform
cancer treatment in the UK.
That's how Charles Sawyers, a 2009 Lasker Award winner and chair
of human oncology and pathogenesis at Memorial Sloan - Kettering
Cancer Center in New York City, made the connection with Bristol Myers Squibb (BMS) that led to second - generation
treatments for chronic myeloid leukemia (CML).
«Our results suggest that engineered
human intestine could provide a viable
treatment to lengthen the gut for patients with gastrointestinal disorders, or patients who lose parts
of their intestines due to
cancer,» said Bitar.
A dozen
human studies
of MDMA, LSD, a powerful African drug called ibogaine and psilocybin, from so - called «magic mushrooms,» are now under way, testing the once - stigmatized drugs as
treatments for not only PTSD, but also cluster headaches and addiction, as well as anxiety and depression in
cancer patients.
«Everything we talked about was about research directly on the embryo,» for example, to improve on infertility
treatment or better understand
cancer biology, says R. Alta Charo, a law professor and bioethicist at the University
of Wisconsin Law School who was a member
of the NIH
Human Embryo Research Panel in the mid-1990s, which considered how embryos might be used in research.
By promoting DNA demethylation, high - dose vitamin C
treatment induced stem cells to mature, and also suppressed the growth
of leukemia
cancer stem cells from
human patients implanted in mice.
The research will also enhance understanding
of how
cancers avoid the immune system, which could have implications for
cancer treatment in
humans.
During lab testing, the compound «markedly inhibited» the growth
of three
human pancreatic
cancer cell lines five days after
treatment and induced the death
of pancreatic
cancer cells.
The researchers hope that ultimately
human trials will prove the efficacy
of the OH14 compound in sensitising tumour cells and
cancer stem cells to existing drug - based therapies thus disabling tumours from seeding new growth after
treatment.
Compared to a control (left), epalrestat
treatment (right) reduces the number
of metastatic tumors (arrowheads) in the lungs
of mice injected with
human basal - like breast
cancer cells.
To that end, in collaboration with the University
of Zurich and MD Anderson
Cancer Center, the researchers tested melanoma tumor samples from
human patients undergoing
treatment with the same targeted therapies.
Notch is under investigation as a target in the
treatment of various
cancers and some drugs that target Notch have been well - tolerated by
humans.
Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy
of this kind
of drug candidates against
cancer stem cells, and the possibility
of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective
of their possible application for the
treatment of human breast
cancer.
Someday, targeted inhibition
of Hh signaling may be effective in the
treatment and prevention
of many types
of human cancers.
Another is that the transplanted bits
of tumor act nothing like
cancers in actual
human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist
treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.
The researchers showed that cabazitaxel worked better than docetaxel in
human prostate
cancer cells lines that were resistant hormone
treatment, both in terms
of slowing
cancer - cell growth and in its ability to kill
cancer cells.
This discovery is in line with the recent advances in
cancer immunotherapy, a field that focuses on the design
of treatments based on the
human immune system.
Additional experiments using a combination
of maraviroc and a drug that blocks the VEGF protein suggest that the
treatment duo could be an effective way to prevent metastatic disease in
human breast
cancer patients, according to the researchers.
The MasSpec Pen rapidly and accurately detects
cancer in
humans during surgery, helping improve
treatment and reduce the chances
of cancer recurrence.
The first child to receive the KTP laser
cancer treatment, he was referred to Zeitels after
cancer was discovered in a biopsy
of what were originally believed to be benign
human papilloma virus (HPV) warts.
The use
of bone marrow - derived stem cells is well established in the
treatment of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.
The resulting «map»
of gene - drug interactions allowed the researchers to accurately predict the responses
of multiple
human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response
of breast and ovarian tumor cells to common classes
of chemotherapy
treatment.
Her research is both translational and clinical in nature and centers on the
human genetics
of healthy skin aging and diseases related to aging skin, including new
treatments for advanced basal cell skin
cancers.
«If further studies validate that these processes are critical in
human breast
cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties
of the extracellular matrix, or that target the receptors and signaling molecules associated with how cells sense this matrix, could be used as a new avenue for the prevention or
treatment of breast
cancers.»
The transplantation
of isolated
human hematopoietic stem cells is used in the
treatment of anemia, immune deficiencies and other diseases, including
cancer.
So - called
cancer immunotherapy — which is the
treatment of tumors by the use
of antibodies — has been established and used very successfully in
human medicine for about 20 years.
Richard Lindsay, a PhD student who worked on the research team, added: «Our findings are
of central importance in understanding how microbial infections evolve, but also have wider significance for the
treatment of cancer and the therapeutic control
of disease in
humans, animals and plants.»
«We are at a point in our research where we have validated the efficacy
of this combination
treatment approach in preclinical animal models, and we now need to define its safety through toxicology and pharmacology studies,» says Fisher, Thelma Newmeyer Corman Endowed Chair in
Cancer Research and co-leader
of the
Cancer Molecular Genetics research program at VCU Massey, chairman
of VCU School
of Medicine's Department
of Human and Molecular Genetics and director
of the VCU Institute
of Molecular Medicine.
Buoyed by these results, Dana - Farber researchers are working to create a derivative
of dBET1 that can be used as a drug in
human patients — and to extend the conjugate strategy for the
treatment of other
cancers and other genetically - caused diseases.
After confirming in mouse models that cells from HER2 - positive breast
cancers became resistant to anti-HER2
treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed in brain metastases
of HER2 - positive breast
cancers from both mice and
human patients.
While it is difficult to say at this point what types
of cancer might be amenable to such an approach, this new concept could lead to an improvement in
human cancer treatment in the long term, the researchers say.
Some experts have traced estrogen - like chemicals to increased rates
of human breast
cancer, and there is even more evidence that they endanger animals by feminizing the sex organs
of male frogs and fish living downstream from sewage
treatment plants.
To test this in a
treatment situation, Peter collaborated with Dr. Shad Thaxton, associate professor
of urology at Feinberg, to deliver the assassin molecules via nanoparticles to mice bearing
human ovarian
cancer.
«Based on this research, we are now conducting a first - in -
human study combining the PARP inhibitor with radiation and chemotherapy in patients with locally advanced pancreatic
cancer, with an ultimate goal
of improving survival rates and
treatment outcomes,» said Tuli.
«First
human application
of novel PET tracer for prostate
cancer: New tracer holds promise
of monitoring targeted
treatment of various
cancers.»
This study provides one
of the first animal models to demonstrate the long - term cognitive deficits resulting from a chemotherapeutic
treatment used in treating
humans for breast
cancer.
In fact, large
human liver
cancer tumors on comparatively small mice started regressing about 20 days after
treatment, and were eradicated by day 41 with the help
of one
of the targeted receptors.
The accumulation
of mutations in the
human genome is at the origin
of cancers, as well as the development
of resistance to
treatments.
Pet dogs may be
humans» best friends in a new arena
of life:
cancer treatment, said University
of Illinois veterinary clinical medicine professor Timothy Fan.
To determine whether the reactivation
of methylation - silenced genes by EGCG is a general phenomenon that also occurs in other cell lines, we studied the effects
of EGCG
treatment on the methylation status and mRNA levels
of p16INK4a or RARβ in three other
human cancer cell lines (Fig. 3C) ⇓.
In a 1988 paper summarizing his findings, Fiebig concluded that xenograft mice were wonderful models for broadly testing new drugs against
human tumors, but they «can not be used as a clinical routine method» for predicting patient
treatment.1 The idea
of using xenograft mice as personal avatars for
cancer patients was discarded.
This apparently symbiotic relationship within tumors has provocative implications for the study and
treatment of human cancers.
Researchers at Sylvester Comprehensive
Cancer Center at the University
of Miami Miller School
of Medicine have discovered a peripheral biomarker in
human blood serum that can be used to detect the presence and progress
of glioblastoma brain tumors before and after
treatment.
This center fosters collaborations among researchers at MD Anderson Smithville, in Houston and with other instutions in central Texas to reach the goal
of understanding how environmental exposures influence
cancer outcomes in the
human population by identifying new targets and strategies for
cancer prevention and
treatment.
LA JOLLA, CA — Discovering that mouse hair has a circadian clock — a 24 - hour cycle
of growth followed by restorative repair — researchers suspect that hair loss in
humans from toxic
cancer radiotherapy and chemotherapy might be minimized if these
treatments are given late in the day.