Sentences with phrase «of human cells tested»

The result was a base editor, called ABE, that could switch A-T base pairs into G - C pairs in about 50 percent of human cells tested.

Not exact matches

Although most states require only a handful of tests, a panel of experts convened by the U.S. Department of Health and Human Services and the March of Dimes recommends newborns be screened for 30 genetic disorders, including hypothyroidism, cystic fibrosis, and sickle cell anemia.

To estimate the prevalence of positive serology among potential donors to a human milk bank.Retrospective review of our experience with donor serological testing at our milk bank over a 6 - year interval.Not - for - profit, regional human milk bank.Volunteer, unpaid potential donors of human milk.Serological testing for syphilis, HIV, hepatitis B, hepatitis C, human T cell lymphotropic virus type 1 (HTLV - 1) and human T cell lymphotropic virus type 2 (HTLV - 2).

As well as allowing the use of stem cells grown from established cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organs.

In a human brain, the cells would need to travel a matter of millimeters or centimeters, up to 20 times farther than the 500 microns tested here, he says.

In November 2010 Japanese researchers announced online in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cells.

Success in mice is no guarantee of success in humans, Yoder says, adding that the cells will also have to be tested against hemangioblasts isolated in other ways.

The biobank of MedUni Vienna and Vienna General Hospital is a central service facility dedicated to the storage of human tissue, cell material and body fluids for more in - depth diagnosis, academic research projects and clinical tests, as well as working - up samples by way of a medical service.

Stahelin and co-investigator Smita Soni, a postdoctoral researcher at the Indiana University School of Medicine, found that VP40 is able to assemble in vitro (i.e., in a test tube), without any human cells present and mediate formation of virus - like particles when the human lipid phosphatidylserine is found in solution with VP40, but not other control lipids.

Liver cells carry out hundreds of different functions, only some of which Lagasse has tested in mice, and it is unlikely that transplanted cells could fulfill all of them in humans.

The team also tested nanoparticle absorption for other kinds of human cells, including fibroblasts from donors of older ages and found significant differences.

ACT is now performing early - phase clinical trials testing the safety of implanting retinal cells derived from human ES cells into the eye to treat certain types of blindness.

The Wyss team believes the ability of the human gut - on - a-chip to culture the microbiome with human gut cells also holds promise for the field of precision medicine, where a patient's own cells and gut microbiota could one day be cultured inside a gut - on - a-chip for testing different therapies and identifying an individualized treatment strategy.

The current test is only able to analyze part of the human immune system, namely the B - cells but not the T - cells, which are needed as helper cells to fight the infection and whose activity indicates the presence of an infection.

The only way the team can be sure they have grown the equivalent of a fetal brain would be to genetically test individual cells from different regions of the organoid, and compare them to those of human fetus, says Christof Koch at the Allen Institute for Brain Science in Seattle.

Some of the leading non-animal tests are conducted on cell cultures, human and animal corneas from eye banks, corneal tissue cultures, and frozen corneas supplied by hospitals.

The screening process identified three promising compounds, which were then tested for their ability to prevent Zika infection of human brain cells.

In their latest study, they tested compounds against cells from nine different types of human cancer, including common types affecting blood, colon, breast, prostate, ovaries, kidneys, and lungs.

Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab - grown human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.

John Glass, a senior microbiologist in the synthetic biology group at the J. Craig Venter Institute in Rockville, Maryland, puts it this way: If you can imagine a set of genes that will program a cell to do something — anything — then you can make them «at a reasonable cost and test your hypothesis... so it will be possible to attempt to design organisms that have extraordinary properties to solve human needs.»

Svendsen is more optimistic about his team's work involving human tests of a novel stem cell approach to treat ALS, a degenerative motor neuron disease in which cells that transmit messages from the brain and spinal cord to the muscles wither or die.

«Starting with our cell model that mimics human pancreatic cancer progression, we identified released proteins, then tested and validated a subset of these proteins as potential plasma biomarkers of this cancer,» Zaret said.

A technique that involves genetically engineering brain cells so that they fire in the presence of certain drugs has been used to treat epilepsy in rats, and it could soon be tested in humans.

While testing the effect of many normal, non-cancerous, human cells on the sensitivity of cancer cells to chemotherapy, they found a specific sample of normal human skin cells that rendered pancreatic cancer cells resistant to gemcitabine.

During lab testing, the compound «markedly inhibited» the growth of three human pancreatic cancer cell lines five days after treatment and induced the death of pancreatic cancer cells.

Researchers studied the structure of proteins from one strain of the H7N9 virus that caused the outbreak and tested how strongly one of the proteins bound to molecules on the surfaces of bird and human cells.

The researchers also tested a Runx2 knock - down variant of a human multiple myeloma cell line and found that it produced significantly less tumor growth in immunodeficient mice than the original human multiple myeloma cells.

In this pilot study to test the safety of putting iPS - derived cells into humans, the six are all receiving a graft of new retinal pigment epithelial cells, which serve to maintain the eye's light - sensing cells.

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

In the past year, the South Korean Food and Drug Administration (FDA) has approved the world's first three stem - cell treatments — Hearticellgram - AMI, Cupistem and Cartistem — which followed on the heels of clinical tests for human embryonic stem - cell therapies approved in 2010, according to the health ministry.

Follow - up tests in human cell cultures confirmed that MIR168a interferes with production of a cholesterol - clearing protein.

In preliminary safety tests, the researchers found no harmful effects in four types of human cells, or in rats.

In studies with human fibroblasts that make up connective tissue, Boger's team tested whether NOD1 activity could affect CMV replication in cultures of cells grown in the lab.

By assessing the survival of the cells that engulf the particles and measuring the levels of red or green light that they emitted, the researchers determined which formulation of particles performed best, then tested that formulation in mice with human brain cancer derived from their patients.

An initial library of 15 biodegradable particle formulations was tested for their ability to carry siRNAs into human glioblastoma cells that were genetically engineered to make green fluorescent protein (GFP).

First, the destabilizing effects of VX - 770 on the corrected CFTR protein might be less robust in the human body than were the effects seen in lab tests using human lung cells.

Tests rely on either expensive equipment for computer - assisted analysis or, in hospitals that can not afford thousands of dollars» worth of machinery, a technician who analyzes sperm cells under a microscope, a process Shafiee says can be subject to human error.

Tests with kidney cancer and two human uterine sarcoma cell lines, one with multidrug resistance, showed that 10 of these new compounds were impressively potent against all three cell lines, the researchers reported.

Certain blood manipulation methods, such as administration of recombinant human erythropoietin (rHuEPO) and homologous blood transfusion, are currently tracked through a longitudinal profile called the athlete biological passport (ABP); however, there is not yet a test available for ABT, which is reinfusion of the athlete's own blood or red cell concentrates.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

To date, the researchers have tested the function of their activation - ready sensor in cell culture of human kidney and cancer cells.

«Having identified this important protein molecule in fruit flies, we can test whether the human version of the protein is important for stem cells and their daughters as well,» said Montell.

Using in vitro, or test tube, experiments, the researchers applied these chemicals to human cancer cells to measure changes of estrogen receptor - and androgen receptor - target genes and transcriptional activity.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

One of these, UJ3, is as effective as the industry - standard drug Cisplatin in killing cancer cells in laboratory tests done on human esophageal cancer, breast cancer and melanoma.

They then tested eight of the most promising candidate drugs against cells grown from other human vestibular schwannomas.

«In the last few years, it has become possible to order cultures of human cells for testing, but they're grown on a plate, a two - dimensional environment,» says Radisic.

Researchers at Rice University's Laboratory for Systems Biology of Human Diseases analyzed the metabolic profiles of hundreds of ovarian tumors and discovered a new test to determine whether ovarian cancer cells have the potential to metastasize.

In this study, the researchers tested the effects of Olaparib on the tumors formed by human breast cancer cells injected into mice.

George Daley, speaking of potential therapeutic testing of parthenote - derived stem cells (the sort that his lab reported isolating last December), said it was «reasonable» to assume that the technology wouldn't be ready for human testing for another seven years.