Sentences with phrase «of human clinical studies»

While there have been a number of human clinical studies, we need larger, randomized, properly - controlled clinical trials that look specifically at these suspects.

Not exact matches

Shorn of human weaknesses like the need to eat or sleep, computers are now speed - reading through not only the vast academic literature but also CT scans, electronic medical records, and mountains of data from clinical trials and genomic studies.

The court's written findings define an «adequate and well - controlled human clinical study» as one lasting a minimum of six weeks using appropriate tools.

[31] Critics also point out that even the $ 6 million attributed to the reduction of mercury emissions is likely an exaggeration because the EPA has ignored clinical studies that demonstrate the human body's ability to protect itself against mercury.

Therefore, PRP has the potential to aid in the healing of multiple acute and chronic injuries; however, the benefit of PRP in human clinical studies has not been proven;

Dr. Eastwood has an undergraduate degree in Human Biology from Stanford University, and a doctorate in clinical psychology from the California Institute of Integral Studies.

In addition to publishing a number of book chapters and journal articles, Mr. Trout has produced 14 clinical training videos that are used by universities and clinics around the world, including the six - hour video training series, The Awakening and Growth of the Human: Studies in Infant Mental Health.

Except for the study cited above, there have been no other reports of clinical problems in infants of mothers with silicone breast implants.21 It is unlikely that elemental silicon causes difficulty, because silicon is present in higher concentrations in cow milk and formula than in milk of humans with implants.22 The anticolic compound simethicone is a silicone and has a structure very similar to the methyl polydimethylsiloxane in breast implants.

The PhD course focuses on various aspects of human (donor) milk, with as main study a randomized clinical trial towards the effects of human donor milk in very low birth weight infants (the Early Nutrition Ststudy a randomized clinical trial towards the effects of human donor milk in very low birth weight infants (the Early Nutrition StudyStudy).

Brown K, Black R, Robertson A, Akhtar N, Ahmed G, Becker S. Clinical and field studies of human lactation: methodological considerations.

She received her undergraduate degree in Human Development and Family Studies from Indiana University in Bloomington, Indiana and her graduate degree in Clinical Mental Health Counseling from Indiana University of Pennsylvania.

Do human clinical studies or epidemiological studies consistently support the concept that high doses of vitamin A may be teratogenic and produce a recognizable group of malformations?

The clinical trial in humans was based on positive results of a study in mice published in Nature Communications in Sept. 2015.

Mitchell guesses that there will probably be 10 more years of rigorous testing in animals before moving on to human clinical studies.

This clinical study, published in the Proceedings of the National Academy of Sciences, tested the possibility of imaging inflammation in the pancreas of human volunteers using ferumoxytol, a coated iron nanoparticle approved by the FDA as an iron replacement therapy, and MRI.

This study represents a significant step towards the development of clinical trials in gene therapy for the curative treatment of hereditary deafness and balance loss in humans.

For those with a research background, it could mean learning clinical study design and the bioethics of human research.

«We have now found a potential mechanism, and at this point in our research, we need to test human participants in a blinded, placebo controlled clinical study — the same technique we used to study the behavioral effects of acupuncture in rats,» says Eshkevari, a nurse anesthetist and licensed acupuncturist.

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

This proof - of - principle study shows «for the first time... that human iPS cells can be used to model a diverse range of inherited diseases in adult cells,» the authors wrote in their paper, published online in The Journal of Clinical Investigation August 25.

If dozens of human and animal studies published over the past six years are borne out by large clinical trials, nicotine — freed at last of its noxious host, tobacco, and delivered instead by chewing gum or transdermal patch — may prove to be a weirdly, improbably effective drug for relieving or preventing a variety of neurological disorders, including Parkinson's disease, mild cognitive impairment (MCI), Tourette's and schizophrenia.

Researchers who conduct animal studies often don't use simple safeguards against biases that have become standard in human clinical trials — or at least they don't report doing so in their scientific papers, making it impossible for readers to ascertain the quality of the work, an analysis of more than 2500 journal articles shows.

«These results provide the basis for the potential implementation of 5 - LO - inhibitors as stem cell therapeutic agents for a sustained AML cure, although this must be investigated further in preclinical and clinical studies in humans,» explains Dr. Ruthardt.

«Overall the turnaround for sample analyses fit a relevant clinical window for future comparative oncology trials to model human PMed advancements,» said Dr. William Hendricks, a TGen Staff Scientist and another author of the study.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Although we can not determine what the effects of AF267B will be in humans until clinical trials are complete, we are very excited by the results our study has yielded.»

Often, those smaller animals express the genetic abnormality very differently from humans, says clinical scientist and pediatric neurologist James Dowling at the University of Michigan, Ann Arbor, who studies the myopathies and their genetic causes in both children and zebrafish.

Regulatory issues must be addressed before moving to human studies, Davies said, but the findings published in the August issue of the Journal of Clinical Investigation suggest that it may be possible to manipulate the bacterial residents of the gut — the gut microbiota — to treat obesity and other chronic diseases.

The team behind the new study looked specifically at the information researchers prepare to justify clinical trials in humans, which can cost millions of dollars.

Once we have demonstrated the proof of concept in animal studies, the next goal will be to work towards the first human clinical trial with graphene devices during intraoperative mapping of the brain.

«Our partnership with families who have a child with Down syndrome and our investment in a comprehensive clinical data and biorepository will continue to provide resources to study not only heart defects, but also other Down - syndrome associated medical conditions such as cognitive function, leukemia, and dementia,» says co-author Stephanie Sherman, PhD, professor of human genetics at Emory University School of Medicine.

Aucott will feature the joint study as an example in his 2016 AAAS Annual Meeting presentation, Big Data Clinical Realities and the Human Dimensions of Interoperable Data.

The discovery of an unexpected biochemical link within tumor cells should lead to clinical trials for experimental drug treatments that indirectly target myc and that already are being evaluated in human studies, the researchers said.

His team hopes to build a predictive model of the human microbiome as a tool to study how medical conditions can change this massive biological system, to identify settings that promote beneficial microbiomes, and to design clinical interventions to treat currently hard - to - manage problems.

Among those is canine compulsive disorder (CCD), the counterpart to human obsessive compulsive disorder (OCD),» says the study's first and corresponding author Nicholas Dodman, BVMS, DACVA, DACVB, professor in clinical sciences and section head and program director of animal behavior at Cummings School of Veterinary Medicine at Tufts University.

of Public Health, Midland, MI and Clinical Associate Professor of Pediatrics and Human Development, Michigan State University, School of Human Medicine, «Our study group consists of premature infants with birthweights at the lowest level that is compatible with life.

The study was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23 HD054720), Flora Family Foundation, UCSF Catalyst Award, UCSF Resource Allocation Program, Brain & Behavior Research Foundation Young Investigator Award, Stanford University Lucile Packard Foundation for Children's Health, Spectrum Child Health & Clinical and Translational Science Award and the Extraordinary Brain Series of the Dyslexia Foundation.

Since CGP3466B has already been tested in phase II clinical trials to (unsuccessfully) treat Parkinson's disease and ALS, it is known to be safe for humans, but the researchers caution that many more years of studies are needed to definitively show whether it is effective for preventing cocaine damage, first in mice, then in humans.

Using simple statistics, without data about published research, Ioannidis argued that the results of large, randomized clinical trials — the gold standard of human research — were likely to be wrong 15 percent of the time and smaller, less rigorous studies are likely to fare even worse.

«The malfunction in this protein has not been previously linked to clinical disorders of the human immune system,» said Ivona Aksentijevich, M.D., staff scientist in NHGRI's Medical Genetics Branch and study co-author.

Like 80 % of humans infected with the Zika virus, most of the non-human primates used in this study lacked any apparent clinical symptoms.

«While the pre-birth programming effect of PETN shows promise for future clinical implications, we must be careful about generalizing findings from animal studies to humans,» Li said.

The Thorough QT clinical assessment also has its limitations, as those studies are done in humans and typically require large numbers of patients.

«By helping us understand that lower levels of RNF125 confer resistance to BRAF inhibitors, we have a new strategy to stratify patients for currently approved therapy versus participation for human clinical trials to investigate whether targeting JAK1 will be more effective in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author of the study.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

Published in the Journal of Clinical Investigation, the study collected metabolic data directly from more than 120 human lung cancer patients.

Melina R. Kibbe, M.D., of the University of North Carolina at Chapel Hill (formerly of Northwestern University, Chicago), and Editor, JAMA Surgery, and colleagues conducted a study to determine if sex bias exists in human surgical clinical research, if data are reported and analyzed using sex as an independent variable, and to identify specialties in which the greatest and least sex biases exist.

Studies in animal models of MS have been a success, and the latest version of the compound is due to start clinical trials in humans by mid-2012.

Bristol - Myers Squibb won its citation «for extending and enhancing human life through innovative pharmaceutical research and development, and for redefining the science of clinical study through groundbreaking and extremely complex clinical trials that are now recognized as industry models.»

«Once we've shown that this can safely be used in human patients with pulmonary hypertension — and we've got a clinical trial in progress right now — we'll be able to conduct studies of inhaled NO delivered in ambulatory settings, including patients» homes, to treat chronic pulmonary hypertension, right - sided heart failure and chronic obstructive pulmonary disease.»