Sentences with phrase «of human disorders»

The technique has already produced more than 500 different models of human disorders, including cardio - vascular diseases, diabetes and cancer.

These procedures generate animals that carry specific genetic alterations, and recreate the underlying cause of a human disorder or uncover the role of any gene of interest.

«This knowledge might in the long - term contribute to the understanding of the underlying mechanisms of human disorders of the nervous system that lead to loss of movement coordination, such as Parkinson's disease.»

Lee says that although he doesn't know of any human disorders that are associated with the loss of p75 in particular, pain sensation is obviously vital for quality of life.

Mutations in a gene called progranulin (GRN) are commonly associated with frontotemporal dementia, but GRN mutations in mice do not mimic all the features of the human disorder, which has limited progress in the development of effective treatments.

The protein mTOR regulates cell growth and metabolism and thus plays a key role in the development of human disorders.

Animal gait is affected in models of human disorders such as Parkinson's Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, spinal cord injury and many others.

Deciphering the place of centrosome dysfunctions in the etiology of human disorders is an active field of fundamental research investigation and one of our main interests.

Can environmental toxins disrupt circadian rhythms — the biological «clock» whose disturbance is linked to chronic inflammation and a host of human disorders?

The progress of high - throughput postgenomic technologies has led to better understanding of human disorders at the molecular level.

Nurix is focused on discovering and developing therapies that modulate the ubiquitin proteasome system (UPS) for the treatment of a broad range of human disorders, most notably cancer.

We note that the standard for showing utility for a compound as a pharmaceutical before the patent office is much lower than that before the FDA, and that a human clinical trial is not necessary to establish utility for an invention related to treatment of human disorders.

«We've realized they are actually a good model of human disorders and development,» Dr. Kurrasch said.

Goal: Characterisation of mouse models for human diseases to understand molecular mechanisms of human disorders and for the development of new therapies

Furthermore, the heterozygous knock in mouse serves as a better animal model of the human disorder, as compared to the homozygous mouse, given that Huntington disease homozygosity is very rare in humans.