Sentences with phrase «of human estrogen»

According to Lise Alschuler, author of the Definitive Guide To Cancer: An Integrative Approach to Prevention, Treatment, and Healing, studies on flax lignans demonstrate safety and efficacy in their use against breast cancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen».

In many in vitro (artificial environment) studies, chrysin has been shown to be a very potent and natural inhibitor of human estrogen aromatase.

As a result, breast cancer cell growth is blocked One study in mice concluded that flaxseed inhibited the growth of human estrogen - dependent breast cancer, and strengthened the tumor - inhibitory effect of tamoxifen.

In a group of women 65 to 80 years of age who had never used hormone replacement therapy of any kind, blood levels of estradiol (one of the human estrogens) were measured.

Not exact matches

Likewise, the phytoestrogens in soy have not only been shown to be metabolized differently than real estrogen (such as that in cows milk), in humans as opposed to rats, but have shown a wide array of anti-cancer effects, including cancers instigated by sex hormones such as estrogen!

The causes for such nausea are not certain, but it is suspected that it is your body's reaction to the rapid changes in hormonal levels such as those of estrogen, progesterone, and hCG (human Chorionic Gonadotropin).

Second, the hormone cocktail of estrogen, human chorionic gonadotropin (hCG), progesterone, and prolactin, which helps to produce breast milk, is in full force, causing breast tissue to grow.

Anderson E, Clarke RB, Howell A. Estrogen responsiveness and control of normal human breast proliferation.

Rather than just being a passive bridge between you and your baby, the placenta also produces hormones and signaling molecules, such as human placental lactogen (HPL), relaxin, oxytocin, progesterone and estrogen, which are necessary for both of you during pregnancy.

Studies of bovine dairy show that human milk actually has higher levels of estrogen, and organically raised cattle produce milk with higher levels of estrogen and progesterone than their conventional counterparts.

The report from the American Academy of Pediatrics also referred to theories that some of the hormones in soy protein formulas can interfere with an infant's reproductive development because of their similarity to the human sex hormone estrogen.

High total and saturated fat intake were associated with greater risk of estrogen receptor - and progesterone receptor - positive (ER+PR +) breast cancer (BC), and human epidermal growth factor 2 receptor - negative (HER2 --RRB- disease, according to a new study published April 9 in the Journal of the National Cancer Institute.

Previous research had suggested that levels of BPA, which mimics the female hormone estrogen in the human body, declined by 50 percent every five hours after it was ingested in foods or water it had leached into from plastic containers.

Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab - grown human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.

Scientists believe that it produces such a wide range of health effects in low doses because it mimics the hormone estrogen, disrupting human development and making it particularly potent for infants.

Using in vitro, or test tube, experiments, the researchers applied these chemicals to human cancer cells to measure changes of estrogen receptor - and androgen receptor - target genes and transcriptional activity.

The sensor sends an electronic signal is the presence of estrogen and, with further development, could test estrogen levels in bodily fluids or test waterways for estrogen contamination that might pose a risk to humans and the environment.

When Tilly and his researchers studied mice that lacked the bax gene, they found that 24 - month - old females — the equivalent of 80 - to 100 - year - old humans — still have functioning, estrogen - producing ovaries.

In the 1930s BPA was identified as a potent mimic of estrogen; it could bind to the same receptors throughout the human body as the natural female hormone.

The reason, according to the research published in the journal Human Reproduction (pdf): soy beans contain high amounts of phytoestrogens, organic compounds that mimic the female hormone estrogen in the human body and, in animal studies, have been shown to reduce testosterone leHuman Reproduction (pdf): soy beans contain high amounts of phytoestrogens, organic compounds that mimic the female hormone estrogen in the human body and, in animal studies, have been shown to reduce testosterone lehuman body and, in animal studies, have been shown to reduce testosterone levels.

«Our studies are beginning to corroborate the idea that environmental estrogen may be associated with endometriosis,» said Germaine Buck - Louis, director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development's epidemiology division in Maryland.

In humans, the ovaries stop releasing estrogen after they run out of eggs.

Some experts have traced estrogen - like chemicals to increased rates of human breast cancer, and there is even more evidence that they endanger animals by feminizing the sex organs of male frogs and fish living downstream from sewage treatment plants.

Four miRNAs associated with aggressiveness of lymph node - negative, estrogen receptor - positive human breast cancer

Estrogen receptor - α but not - β or GPER inhibits high glucose - induced human VSMC proliferation: potential role of ROS and ERK

The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue: influence of gender and site

Zhu Q, Jin L, Casero RA, Davidson NE, Huang Y. Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells.

Berkeley Lab researchers have developed the first clinically - relevant mouse model of human breast cancer to successfully express functional estrogen receptor positive adenocarcinomas.

Chemotherapy is a key part of the standard treatment regimen for triple - negative breast cancer patients whose cancer lacks expression of estrogen and progesterone receptors and the human epidermal growth factor receptor 2...

Triple negative breast cancer is a type of breast cancer that does not express receptors for the hormones estrogen and progesterone, or for human epidermal growth factor.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranEstrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranestrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

In the early 1970s, the tragic health impacts of diethylstilbestrol (DES), an estrogen - based drug that was thought to prevent miscarriage, introduced the possibility of hormone disruption as a threat to human health and development that sparked intensive study of estrogens in the environment.

Dr. Mack's research has focused primarily on the use of novel antitumor agents in human estrogen receptor negative breast tumor cells, and more recently, on the use of bioflavonoids in the regulation of estrogen receptor positive (ER +) and estrogen receptor negative (ER --RRB- breast tumor cell proliferation.

In this report the American Council on Science and Health (ACSH) explores the endocrine disrupter hypothesis, which asserts that certain (primarily man - made) chemicals act as, or interfere with, human hormones (specifically estrogens) in the body and thus cause a range of defects and diseases related to the endocrine system.

Humans are exposed through their diet to estrogenic substances (substances having an effect similar to that of the human hormone estrogen) found in many plants.

These results, also presented at the 2015 European Cancer Congress (ECC2015, abstract # 5BA) today, which involve the group of 1,626 patients with a Recurrence Score between 0 and 10, demonstrated that 99.3 percent of node - negative, estrogen receptor (ER)- positive, human epidermal growth factor receptor 2 (HER2)- negative patients who met accepted guidelines for recommending chemotherapy in addition to hormonal therapy, had no distant recurrence at five years after treatment with hormonal therapy alone.

Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative breast cancer — so called because tumor cells in this particularly aggressive form of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER - 2).

This is partly due to reduction in the production of hormones such as testosterone, human growth hormone and estrogen and also because of lack of weight - bearing activity.

Although not identical to human estrogens, they are close enough to confuse the body and interfere with the production and utilization of all hormones.

While it is made of natural estrogens, most of them are natural to horses, not humans, which means they have different effects on your body than human estrogens.

Premarin, made from the urine of pregnant horses, simply doesn't function exactly like the estrogens made in the human body.

Though to date, research hasn't shown a direct link between the water we drink and feminization in humans, there's plenty of indirect evidence that suggests estrogen in our drinking water is at least playing a big role in our feminization as a species, along with all the other sources of estrogen we're exposed to on a daily basis.

The major route of estrogen elimination in humans is through Phase II glucuronidation (conjugation with glucuronic acid) in the liver.

Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum * by liquid chromatography - tandem mass spectrometry.

Although NCI arrived at this conclusion due to the preponderance of thyroid cancer cases in women under age 45, human estrogens should be regarded as just one piece of the hormonal picture.

Originated 1970s by Dr. Henry Lemon, who tested estrogen levels in 24 hour urine samples and found that an EQ > 1 strongly correlated with a higher survival rate after breast cancer.24 Further research conducted by Lemon, Heidel, et al., a meta - analysis of published fractional estrogen excretion collected from 2,846 healthy women worldwide aged 15 to 59 years, with a risk of breast cancer varying five-fold, found that an EQ < 1 reflects increased rates of oxidation of estrone or estradiol to 4 - OH catechols (also referred to in the literature as the 3,4 - catechol estrogen quinones), which have been identified as the principal proximal human mammary carcinogens after menarche, while an EQ > 1 reflects conversion to protective 2 - OH estrogen metabolites.2526

HGH or Human Growth Hormone is the most comprehensive anti aging hormone that has the potential to control the levels of other hormones in the body — testosterone in men and estrogen in women.

Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention.

Research performed on human males with androgen insensitivity syndrome compared to the classical sexual development models which were created from research on rats, indicates that the rat model does not account for the sensitivity of the hypothalamal - hypophyseal - gonadal axis with fluctuations in hormonal levels, namely androgens and estrogens.7

Genistein Inhibits Both Estrogen and Growth Factor — stimulated Proliferation of Human Breast Cancer Cells Cell Growth & Differentiation 1996 (Oct); 7 (10): 1345 — 1351 Genistein is a naturally occurring dietary protein tyrosine kinase (PTK) inhibitor that is hypothesized to be responsible for the lower rate of breast cancer observed in Asian women consuming soy.