Sentences with phrase «of human genomics»

The Broad Foundation invests in scientific and medical research in the areas of human genomics, stem cell research and inflammatory bowel disease.

The Eli and Edythe Broad Foundation invests in innovative scientific and medical research in the areas of human genomics, stem cell research and inflammatory bowel disease.

Elected by his peers, Liu was recognized for his distinguished contributions to cancer biology, particularly the molecular analysis of breast cancer, and to the global advancement of human genomics.

And let's face it, exome sequencing lets us conveniently avoid some of the most challenging aspects of human genomics, like detecting complex rearrangements (SVs) and interpreting noncoding regulatory variants.

These reference standards consist of human genomic DNA fragmented to 160 base pairs, representative of plasma - derived cfDNA, and are provided as a set of precisely defined allelic frequencies from as low as 0.1 %.

«We are analyzing massively large sets of human genomic data to ultimately improve our understanding of genetic basis of diseases.»

Up to 98 percent of human genomic matter is known as «junk» or «dark matter» non-coding DNA, and had for years attracted little interest among scientists who doubted its role in human health and disease.

The code does not place unrealistic demands on scientists, says Himla Soodyall, director of the Human Genomic Diversity and Disease Research Unit at South Africa's University of the Witwatersrand in Johannesburg.

Not exact matches

Shorn of human weaknesses like the need to eat or sleep, computers are now speed - reading through not only the vast academic literature but also CT scans, electronic medical records, and mountains of data from clinical trials and genomic studies.

His institute is a leading research organization dedicated to genomic research, and he's the co-founder, chairman and CEO of Human Longevity.

His institute is a leading organization dedicated to genomic research, and he's the co-founder, executive chairman and CEO of Human Longevity.

Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.

Sir John Bell, professor of medical sciences at Oxford University and government advisor on human genomics believes this will transform cancer treatment in the UK.

«Now, using genomic methods that were not available 10 years ago, it appears that components made by the virus interact with human DNA in the places where the genetic risk of disease is increased,» Harley says.

Last June, he switched to the Department of Human DNA Variability at the Centre for Genomic and Oncological Research in Granada.

«Human and chimpanzee genes differ very little, so one hypothesis in evolutionary genomics holds that humans and chimpanzees are so phenotypically different because of differences in the way they regulate gene expression.

«However, because SIF - seq only requires DNA sequence from a mammal and can be used in a variety of cell types, it should be possible to compare the neuronal enhancers present in a large genomic region from human to the neuronal enhancers present in the orthologous chimpanzee region.

The U.S. National Institutes of Health (NIH) has made major investments in network approaches in many areas, including cancer biology, cardiovascular and metabolic diseases, neurophysiology, and human genetics and genomics.

Even though Rienhoff is the founder of two biotechnology companies and holds a medical degree from Johns Hopkins University, he has conducted his hunt not as an expert in human genomics but as a do - it - yourself biologist, teaching himself the tricks of the trade as he moves along and doing his research at home.

Now he and his collaborators have carried out an extensive analysis of human KZFPs, retracing their evolutionary history and identifying their genomic targets.

EPFL scientists have carried out a genomic and evolutionary study of a large and enigmatic family of human proteins, to demonstrate that it is responsible for harnessing the millions of transposable elements in the human genome.

Producing a short list of strong candidates was in itself a feat, accomplished by applying the right filters to analysis of human and chimpanzee genomes, said co-author Gregory Wray, professor of biology and director of the Duke Center for Genomic and Computational Biology.

Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors.

In the new study, researchers mined databases of genomic data from humans and chimpanzees, to find enhancers expressed primarily in the brain tissue and early in development.

«They are developing the clinical genomics necessary to foster and support the Precision Medicine Initiative of the National Institutes of Health, and generating the genomics data that further drives human genome research.»

«We feel it's critical that the scientific community consider the potential hazards of all off - target mutations caused by CRISPR, including single nucleotide mutations and mutations in non-coding regions of the genome,» says co-author Stephen Tsang, MD, PhD, the Laszlo T. Bito Associate Professor of Ophthalmology and associate professor of pathology and cell biology at Columbia University Medical Center, and in Columbia's Institute of Genomic Medicine and the Institute of Human Nutrition.

Comparisons of the Neandertal genome to the genomes of five present - day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development.

Since the completion of the Human Genome Project in 2003, scientists have expanded their knowledge of how living cells work with new approaches including genomics, proteomics, and systems biology.

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

In the last four years, the U.S. - based Human Microbiome Project used genomic analysis to identify bacteria, viruses, fungi, archaea, and protozoa in the noses, gums, tonsils, genital tracts, and guts of 242 healthy Americans between the ages of 18 and 40; more than 11,000 samples were taken in all.

Researchers at the Sainte - Justine University Hospital Center and University of Montreal have discovered that the genomic signature inherited by today's 6 million French Canadians from the first 8,500 French settlers who colonized New France some 400 years ago has gone through an unparalleled change in human history, in a remarkably short timescale.

Using genomic analysis to study cancer in dogs can help develop new therapies for humans with cancer, according to a proof - of - concept study led by the National Cancer Institute (NCI) and the Translational Genomics Research Institute (TGen).

«The human part of it really got a lot of people overly excited, and that kind of overshadowed the intent to make it be about writing genomic sequences in general,» Boeke says.

But now «the approach can be reset using the bacterial and human genomic data,» says immunologist Steven Schutzer of the University of Medicine and Dentistry of New Jersey.

The first government - funded human genomics research study performed on African soil — aimed at unlocking the unique genetic character of southern African populations — has revealed a high level of genetic diversity.

A genomic analysis of ancient human remains from KwaZulu - Natal revealed that southern Africa has an important role to play in writing the history of humankind.

The U.S. - based Human Microbiome Project used genomic analysis to I.D. microbes in the noses, gums, tonsils, genital tracts and guts of more than 200 Americans.

Among other initiatives, his group contributes to ENCODE (Encyclopedia of DNA Elements), supported by NIH to define functional genomic elements; the DOE Systems Biology Knowledgebase (KBase) for data sharing and analysis; and the internationally funded 1000 Genomes Project on human genetic variation.

Given 10 years» of hindsight and the current set of obstacles, it's no surprise that researchers now state somewhat modest expectations for what human genomics can deliver and by when.

As part of the Human Genome Project, the government required researchers to make their genomic data and related code available freely.

The move comes in response to the announcement earlier this week of a new U.S. company, launched by sequencing - machine manufacturer Perkin - Elmer and J. Craig Venter of The Institute for Genomic Research, that plans a brute - force approach to sequencing the human genome within 3 years (ScienceNOW, 12 May).

«With large present - day genomic datasets and increased international collaboration to handle the many newly sequenced ancient datasets, there is huge potential to understand the biology of human prehistory in a way that has never been accessible before.»

«Genetic engineering of human stem cells has not been used for disease - associated genomic deletions,» said Dr. Papapetrou.

But determining which specific genetic changes led to humans won't be easy, says Asao Fujiyama, of RIKEN Genomic Sciences Center and the National Institute of Informatics in Japan, one of the project leaders: «The key proteins are very difficult to iron out because we have so many differences.»

«Right now, the research group is analyzing the nuclear genome the results of which could provide us with information about its relationship with the Neanderthals and about the existence of genomic variations associated with the immune system that accounts for the evolutionary success of Homo sapiens over other human species with whom it co-existed.

«Think of the advances being made in genomics, for example, due to the human genome project and the free - flowing findings and data.

As anthropologists use all the latest tools — genomics, computer analysis, and increasingly sophisticated imaging — to extract deep secrets from the latest fossil finds, they are replacing the «ascent of man» with a captivating new picture of the human family.

Yet a third player in the emerging algae fuel market is Synthetic Genomics, the brainchild of genomics guru Craig Venter, who beat the U.S. government in sequencing the human genome and at a fraction of the cost.

But now that increasingly powerful genomic technology can definitively identify a species from a fragment of bone or uncover Neanderthal genes embedded in the DNA of modern humans, there is less room for debate.

In the current study, for example, they utilized genomic information from hundreds of microbial species commonly found in humans to create computer models of nutrient and energy metabolism.