Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas
of human glioblastomas but which, lacking tumor stem cells, were nothing of the kind.
The team found that exposing samples
of human glioblastoma tumours grown in a dish to the Zika virus destroyed the cancer stem cells.
Therapeutic efficacy of aldoxorubicin in an intracranial xenograft mouse model
of human glioblastoma.
Not exact matches
In a series
of experiments, the researchers first identified a set
of 19 transcription factors that were expressed at significantly greater levels in cultured
human glioblastoma stem cells capable
of tumor propagation than in differentiated tumor cells.
An initial library
of 15 biodegradable particle formulations was tested for their ability to carry siRNAs into
human glioblastoma cells that were genetically engineered to make green fluorescent protein (GFP).
This new generation
of viruses has been genetically «targeted and armed,» says Winald Gerritsen
of the VU University Medical Center in Amsterdam, who is involved in an early
human trial
of an engineered adeno - associated virus that attacks
glioblastoma, an aggressive form
of brain cancer.
Another is that the transplanted bits
of tumor act nothing like cancers in actual
human brains, Fine and colleagues reported in 2006: Real - life
glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.
Shah next plans to rationally combine the toxin - secreting stem cells with a number
of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models
of glioblastoma, the most common brain tumor in
human adults.
Into the cerebral cortex
of mice with these light - sensitive proteins, the team implanted cancer cells from a
human pediatric cortical
glioblastoma.
It is a continuation
of previous research, published in 2011, that focused on the effect
of decitabine on
glioblastoma human cell cultures.
Researchers at Sylvester Comprehensive Cancer Center at the University
of Miami Miller School
of Medicine have discovered a peripheral biomarker in
human blood serum that can be used to detect the presence and progress
of glioblastoma brain tumors before and after treatment.
Dr. Iavarone's paper is titled, «Transforming Fusions
of FGFR and TACC Genes in
Human Glioblastoma.»
Our group established that pediatric
Glioblastoma Multiforme (GBM), which is one
of the deadliest cancers in
humans, are molecularly and genetically distinct from adult GBM.
These results could pave the way for the use
of progesterone against
glioblastoma in a
human clinical trial, perhaps in combination with standard -
of - care therapeutic agents such as temozolomide.
Figure 2: Abnormal accumulation
of the FGFR - TACC fusion protein (red) in
glioblastoma stem cells isolated from a primary
human glioblastoma with fused FGFR - TACC genes.
Anticancer effects
of niclosamide in
human glioblastoma.
In another study, 11
human cancer cell lines (carcinomas and
glioblastomas) were exposed to ascorbic acid in which 55 %
of the cell lines were more susceptible (EC50 ≤ 20 mmol / L) and 45 % were more resistant (EC50 > 20 mmol / L) to incubation.
Dogs and
humans share a particularly deadly form
of brain cancer:
glioblastoma.