A veterinarian might decide to run a rapid, «on - site» test, or immunoassay, to support a possible flu diagnosis, which reliably detects components
of human influenza A in human respiratory secretions.
A new study, led by Assistant Professor Vijay Dhanasekaran and Associate Professor Gavin Smith from Duke - NUS Graduate Medical School (Duke - NUS), has presented the largest comparative analysis
of human influenza B viruses undertaken to date.
«These characteristics fit with increased virulence of these emerging avian H7 viruses compared to
that of human influenza viruses,» says Dr. Kuiken.
The document was crafted to help foodservice distributors — and other members of the foodservice supply channel — plan for the far - reaching effects
of a human influenza pandemic.
Not exact matches
This was the most severe
influenza outbreak
of the twentieth century and, in terms
of total numbers
of deaths, possibly the most devastating epidemic in
human history.
An infectious disease caused by type - A strains
of the
influenza virus that is transmittable from birds to
humans.
Pigs can catch
human strains as well, and
influenza is one
of the most costly porcine pathogens for the $ 19 - billion, 113 - million - hog U.S. industry.
The swelling circles represent the amount
of human - origin
influenza in swine population, «with the viral populations increasing first in Oklahoma and then in Minnesota and Iowa,» as pigs move from the south - central to the Midwest.
There have been a number
of significant pandemics in
human history, generally zoonoses that came about with domestication
of animals - such as
influenza and tuberculosis.
Nelson and her colleagues found that flu in pigs «follows long - distance swine movements from the southern U.S. to the Midwest,» with most
of the
human - origin H1N1 arriving at Midwest hog farms coming from the Southeast, and most
of the swine - origin H1N2 coming from the south - central U.S. And that means the Midwest, as the final destination for many
of these pigs, is «likely to provide a reservoir for multiple genetically distinct variants to co-circulate and exchange segments via re-assortment because
of the continual importation
of swine
influenza viruses from other regions,» the researchers noted.
There are a relatively limited number
of documented cases
of zoonotic [
human - communicable] swine
influenza in the literature.
Yet a novel strain
of the
influenza A (H1N1) virus jumped species and burst into the
human population in March and April, and by late May health and agriculture officials were still trying to figure out where it came from.
«You render the most pathogenic
influenza virus known to
humans nontransmissible — that's fascinating,» says bioengineer Ram Sasisekharan
of the Massachusetts Institute
of Technology, who was not part
of the study.
An international team
of influenza researchers in China, the United Kingdom and the United States has used genetic sequencing to trace the source and evolution
of the avian H7N9
influenza virus that emerged in
humans in China earlier this year.
The team focused on these antibodies, which together target the two types
of influenza viruses that contain all strains known to cause disease in
humans.
Among the copious species
of poultry in China, quail and chickens are the likely sources
of infection
of H7N9
influenza virus to
humans, according to a paper published ahead
of print in the Journal
of Virology.
These animals are common hosts for the
influenza virus, which comes in a wide range
of strengths and types — some
of which can infect
humans.
Since then, he and his colleagues have modified the sequences
of influenza viruses to bind to a natural microRNA expressed in
humans and mice, in essence developing a virus that's knocked down by the body's natural microRNA.
The study, led by Nancy J. Cox
of the Centers
of Disease Control and Prevention describes a molecular analysis
of the novel
influenza A (H1N1) virus infecting
humans in several parts
of the world.
If further studies in
humans prove successful, this research could have broad implications for the prevention
of influenza and, by extension, as an approach for other infectious diseases as well.
Why would scientists deliberately create a form
of the H5N1 avian
influenza virus that is probably highly transmissible in
humans?
Pandemic flu continues to threaten public health, especially in the wake
of the recent emergence
of an H7N9 low pathogenic avian
influenza strain in
humans.
The new flu, known as H7N9 avian
influenza, latches onto sugars that coat bird cells — and it can cling to sugars on
human cells too, Yuelong Shu
of the China Center for Disease Control and Prevention and colleagues...
A laboratory test showing airborne transmission
of the H7N9 avian
influenza virus between the animals has raised fears that the virus is poised to become a
human pandemic.
Pigs have multiple
influenza receptors and can harbor
human and avian strains
of the virus in addition to their own, leading to reassortment.
Researchers quickly discovered that the virus was a type
of avian
influenza, known as H7N9, never before seen in
humans.
In March 2013 the first
human infections with the avian
influenza A (H7N9) virus were reported in China, and since that time hundreds
of cases have been documented.
The newly discovered viruses appeared in every family or genus
of RNA virus associated with vertebrate infection, including those containing
human pathogens such as
influenza virus.
In early 2009, a novel
influenza A (H1N1) virus appeared in
humans, containing a unique combination
of influenza genes which had not previously been identified in animals or people.
A total
of 145 patients has been diagnosed in recent weeks with a strain
of the H3N2 animal
influenza virus, but it likely has not yet evolved the ability to transmit efficiently between
humans
«I'm not saying that everyone who has
influenza is cognitively impaired for 10 years,» he says, noting that
human brains are much more complex than those
of mice.
«RNA interference is activated in
human response to
influenza, other important viruses: Discovery could lead to better ways
of combating serious infections, including Ebola and Zika.»
These results firmly establish broad antiviral activity
of Ci extracts against various major
human viral pathogens, including previously reported activity against
influenza viruses.
The paper focuses on two key molecular players in the story
of influenza infection: a
human protein called TRIM25, which was recently discovered to play an important role in the
human immune response to flu infection; and a protein called NS1 present in all strains
of the
influenza A virus and shown to bind TRIM25 to keep it from doing its job.
Just as flu season swings into full gear, researchers from the University
of Colorado Boulder and University
of Texas at Austin have uncovered a previously unknown mechanism by which the
human immune system tries to battle the
influenza A virus.
A new study has found that a novel avian - origin H7N9
influenza A virus, which has recently emerged in
humans, attaches moderately or abundantly to the epithelium
of both the upper and lower respiratory tracts.
Using virus histochemical analysis, the investigators looked at the pattern
of attachment
of two genetically engineered emerging H7 viruses (containing the hemagglutinin (HA)
of either
influenza virus A / Shanghai / 1 / 13 or A / Anhui / 1 / 13) to fixed
human respiratory tract tissues and compared the findings to attachment patterns seen with
human influenza viruses with high transmissibility but low virulence (seasonal H3N2 and pandemic H1N1) and highly pathogenic avian
influenza (HPAI) viruses with low transmissibility and high virulence (H5N1 and H7N7).
Genetic analysis shows that the virus is a mix
of avian and swine viruses from North America, a swine flu strain usually seen in Asia, and a
human influenza strain.
Currently, seasonal flu vaccines are designed to induce high levels
of protective antibodies against hemagglutinin (HA), a protein found on the surface
of the
influenza virus that enables the virus to enter a
human cell and initiate infection.
Question: And is this the first known case in the world
of the countries that are experiencing outbreak
of human swine
influenza where you've seen the flu infect a pig?
The first report
of infections
of humans with the
influenza A virus
of the subtype H7N9 surfaced in March 2013.
All
influenza viruses ultimately come from birds, and the paper begins the somewhat operatic and knotty story
of this outbreak's origins with an H1N1 first isolated in swine in 1930, which itself was a close relative
of the virus that caused the 1918 pandemic in
humans.
When they delivered this virus into the noses
of mice and ferrets, the animals» epithelial cells produced the desired antibodies; they then «challenged» the animals with a range
of dangerous
influenza viruses that no single vaccine can outwit, including H5N1, which kills both birds and
humans, and the H1N1 that caused the infamous 1918 pandemic.
Unfortunately, we have already seen certain trading partners implement trading restrictions based
of the detection
of H1N1
influenza virus in
humans.
They found that like other avian
influenza viruses, the H7N9 viruses attached more strongly to lower parts
of the
human respiratory tract than to upper parts.
It's been well researched, by studies, by world organizations, by the Centre for Disease Control in Atlanta, other organizations that have all unanimously come to the conclusion that consumption
of pork is not a risk factor for transmission
of influenza virus from swine to
human.
A steep increase
of human cases
of avian
influenza A (H7N9) has been reported since the beginning
of December 2016 from China.
«The whole purpose is to study the responses
of human and animal bodies to infection from
influenza, Ebola, SARS and MERS, and to understand how they occur,» Kawaoka explains.
Using X-ray crystallography, performed at the European Synchrotron Radiation Facility (ESRF) in Grenoble, Cusack and colleagues were able to determine the atomic structure
of the whole polymerase from two strains
of influenza:
influenza B, one
of the strains that cause seasonal flu in
humans, but which evolves slowly and therefore isn't considered a pandemic threat; and the strain
of influenza A — the fast - evolving strain that affects
humans, birds and other animals and can cause pandemics — that infects bats.
Since at least 2005, researchers have been deliberately creating
influenza viruses that are both highly virulent (killing several percent or more
of those infected) and spread easily among
humans.