One study presented in the journal — from a group led by Patrick Singleton, PhD, assistant professor of medicine at the University of Chicago Medicine — shows how opioids already present in the body can enhance the malignant tendencies
of human lung cancer cells transplanted into mice, even without the addition of morphine.
Diseases affecting the lung, including emphysema, cystic fibrosis, acute respiratory distress syndrome and pulmonary fibrosis, cause considerable morbidity and mortality in the U.S.. However, there are not many treatment options available for those diseases, in part due to the limited availability
of human lung cells for research.
Dumeetha Luthra is amazed by the team's cellular reconstruction
of a human lung on a microchip.
Their findings, published last week in the Proceedings of the National Academy of Sciences, may provide clues for understanding how some forms
of human lung cancer initiate and may also aid in the development of tools for successful gene therapy of lung diseases such as cystic fibrosis.
The public disclosure of this expanded collaboration coincides with the publication in the peer reviewed journal Nature Methods of data showing new capabilities of the Lung - Chip technology to achieve accurate modeling
of the human lung small airways.
Römer and Eierhoff found evidence of the new mechanism in synthetic membranes as well as in cultures
of human lung cells.
They showed that it slowed the growth
of human lung cancer cells but not kidney cancer cells in these mice.
The authors developed a model
of human lung culture and validated these results in the context
of human lung growth.
Kang found Korean red ginseng extract improved the survival
of human lung epithelial cells against RSV infection and inhibited the virus from replicating, or multiplying, in the body.
He found that red ginseng extract improves the survival
of human lung epithelial cells infected with influenza virus.
This tiny chip made from a polymer and loaded with human cells is designed to serve as a miniature replica
of a human lung.
One sponge - like rangeomorph had a surface area of 58 square metres, about the same as the interior
of a human lung (PNAS, doi.org/t6d).
Researchers showed that flu infection changed the metabolism
of human lung epithelial cells, the prime location for replication of flu virus.
Polarized xenon is also used as a contrast agent to enhance images in experimental magnetic resonance imaging (MRI)
of human lungs, but conventional systems for producing and using this gas can be as big as a car.
In particulate form, as sulfates and nitrates, it gets lodged in the tiniest recesses
of human lungs and causes major health problems.
Not exact matches
But with the exception (perhaps)
of some infections,
human disease, including
lung cancer, is rarely «caused» by one (and only one) thing.
Panoskaltsis - Mortari's team has been working on rebuilding
lungs and other parts
of the respiratory system using
human stem cells.
By printing multiple
lung airways — or any other afflicted organ — from a
human patient and testing drugs on them, pharma companies can bypass the ethically challenged practice
of testing on animals and proceed to
human clinical trials with greater confidence the drugs will actually work, according to Wadsworth.
With the victims
of lung cancer we have the good sense to respond at the point
of human suffering rather than the point
of moral judgment.
I would like to repeat, the brain is just like any other organ and just as capable
of failing as a
human heart, a kidney or a
lung.
Every breath we take includes about a billion oxygen molecules that have been, at one time or another, in the
lungs of every one
of the fifty billion
humans who have ever lived.
He believes that the popularly «conservative» refusal to relate global warming to
human activity is like tobacco company executives» denial
of a link between smoking and
lung cancer.
Granted, there are more benefits to reducing particulate and greenhouse gas emissions than just climate change, i.e. PM 2.5 which can be stuck in the
human lung and cause cancer / respiratory issues, SO2 which contributes to acid rain (we've already eliminated the majority
of this problem), as well as soot (nobody wants the surrounding area covered in ash).
She has got to have the best
lungs of any
human on the planet.
This entry was posted in Pen and Cob's Corner and tagged growth, developing body,
lung problems, heart problems, gland, appetite,
human growth hormone, importance
of sleep, child sleep, growing up, baby sleep, sleep on January 16, 2015 by Swanling Marketing.
The amount and form
of radioactivity in
human milk after
lung scanning, renography and placental localization by 131 I labelled tracers.
The study drew data from the Pregnancy Outcomes and Community Health (POUCH) and POUCHmoms studies, which were funded by the National Institute
of Child Health and
Human Development and the National Heart,
Lung, and Blood Institute.
In
human terms, the costs
of lives and families damaged by heart disease, strokes, cancer and
lung disease are incalculable.
I suspected if we could comprehensively measure all Olympians in finals, we would see significant differences [when compared to non-Olympians], but we would not see them having freakish things like 200 percent more
lung capacity, or muscles that can contract at twice the [maximum] force
of a normal
human muscle.
Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory - grown,
human airway cells that a condensed form
of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward
lung cancer development.
To create the effect
of tobacco smoke on cells, Vaz, Baylin and their colleagues began their studies with
human bronchial cells, which line the airways
of the
lungs, and grew them in a laboratory.
The BioBag could improve
human infant mortality rates and lower the chances
of a premature baby developing
lung problems or cognitive disorders.
Funding for this study was provided by the Eunice Kennedy Shriver National Institute
of Child Health and
Human Development; the National Heart,
Lung, and Blood Institute; the American Thoracic Society / American
Lung Association Partner Grant; and the Respiratory Health Association.
Ultimately, the goal is to make chips that mimic more complex systems — perhaps even entire
humans, says Donald Ingber, director
of Harvard's Wyss Institute for Biologically Inspired Engineering and co-creator
of the
lung - on - a-chip.
By the 1990s, the Owens Lake playa was the largest producer in North America
of PM10 atmospheric dust — particulate matter small enough to enter
human lungs.
Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution
of methylation along the genome in several different
human cell types, including normal and cancerous colon,
lung and liver cells, as well as brain, skin, blood and embryonic stem cells.
Scientists have long experimented with organs - on - chips: tiny representations
of human organs, such as
lungs, hearts and intestines, made from cells embedded on plastic about the size
of a computer memory stick.
Professor Heiner Boeing, also from the German Institute
of Human Nutrition, added, «In addition to the many noted benefits for cardiovascular health, and risk
of lung disease and cancer, it is clear that dental health is yet another reason not to take up smoking, or to quit smoking now.»
In their latest study, they tested compounds against cells from nine different types
of human cancer, including common types affecting blood, colon, breast, prostate, ovaries, kidneys, and
lungs.
In experiments conducted on
human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability
of the endothelium, which lines the walls
of blood and lymph vessels.
As it can take weeks to grow
human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the
lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity
of cells cultured within these microfluidic devices over extended times.
Last June Ingber's team reported that it had placed
human lung lining cells and
human capillary cells on either side
of a porous, flexible polymer membrane.
«There's a potential protective effect here,» says
human geneticist Andrew Johnson
of the National Heart,
Lung, and Blood Institute in Framingham, Massachusetts.
The team studied the impacts
of sulphur emitted by ships using current marine fuels, which produce air pollution particles that are small enough to be breathed deeply into the
lungs and are considered harmful to
human health.
As Paul Rozin, often called the «father
of the psychology
of disgust», has pointed out, we live in a world where the air we breathe comes from the
lungs of other people, and contains molecules
of animal and
human faeces.
Compared to a control (left), epalrestat treatment (right) reduces the number
of metastatic tumors (arrowheads) in the
lungs of mice injected with
human basal - like breast cancer cells.
Working in
human lung epithelial cells, researchers used a variety
of techniques to show that flu infection increased activity
of the PI3K and mTOR pathways and that BEZ235 restored PI3K and mTOR activity to pre-infection levels.
Their major hurdle: to come up with a replacement for hemoglobin (an iron - enriched protein in red blood cells that transports oxygen from the
lungs to the rest
of the body) that can be directly introduced into the
human circulatory system.
Virologist Yoshihiro Kawaoka
of the University
of Wisconsin and University
of Tokyo and his colleagues tested strains
of H5N1 isolated from respiratory tissue in the noses, throats and
lungs of infected
humans.
They found out that TiY is capable
of distinguishing TICs from non-TICs in various
human lung cancer cell lines and patient - derived
lung tumors.