Sentences with phrase «of human lung cancer»

One study presented in the journal — from a group led by Patrick Singleton, PhD, assistant professor of medicine at the University of Chicago Medicine — shows how opioids already present in the body can enhance the malignant tendencies of human lung cancer cells transplanted into mice, even without the addition of morphine.

Their findings, published last week in the Proceedings of the National Academy of Sciences, may provide clues for understanding how some forms of human lung cancer initiate and may also aid in the development of tools for successful gene therapy of lung diseases such as cystic fibrosis.

They showed that it slowed the growth of human lung cancer cells but not kidney cancer cells in these mice.

Not exact matches

But with the exception (perhaps) of some infections, human disease, including lung cancer, is rarely «caused» by one (and only one) thing.

With the victims of lung cancer we have the good sense to respond at the point of human suffering rather than the point of moral judgment.

He believes that the popularly «conservative» refusal to relate global warming to human activity is like tobacco company executives» denial of a link between smoking and lung cancer.

Granted, there are more benefits to reducing particulate and greenhouse gas emissions than just climate change, i.e. PM 2.5 which can be stuck in the human lung and cause cancer / respiratory issues, SO2 which contributes to acid rain (we've already eliminated the majority of this problem), as well as soot (nobody wants the surrounding area covered in ash).

In human terms, the costs of lives and families damaged by heart disease, strokes, cancer and lung disease are incalculable.

Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer develoCancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer develocancer development.

Professor Heiner Boeing, also from the German Institute of Human Nutrition, added, «In addition to the many noted benefits for cardiovascular health, and risk of lung disease and cancer, it is clear that dental health is yet another reason not to take up smoking, or to quit smoking now.»

In their latest study, they tested compounds against cells from nine different types of human cancer, including common types affecting blood, colon, breast, prostate, ovaries, kidneys, and lungs.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

They found out that TiY is capable of distinguishing TICs from non-TICs in various human lung cancer cell lines and patient - derived lung tumors.

Beyond lung cancer, TiY is able to target TICs in 28 types of human cell lines derived from the central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer.

The study has produced more than 20 publications examining a range of complex human conditions, including cardiovascular disease, breast and lung cancer, and type I and II diabetes.

Using both fruit fly and human lung cancer cell lines, researchers targeted two of the most common genetic mutations associated with NSCLC — Ras and PTEN (P13K).

Finally, a Calgary, Alberta — based company, Oncolytics Biotech, is testing a reovirus (an RNA virus often found in human lungs but thought to be nonpathogenic) against several types of cancer, including that of the lung and skin as well as head and neck malignancies.

Normal human colon cells, kidney cells, lung cancer cells and two strains of colon cancer cells didn't respond to the bacteria.

One of those genes, K - Ras, which was discovered nearly 30 years ago, is mutated in 30 percent of human tumors, including 90 percent of pancreatic cancers, 40 percent of colon cancers, and 20 percent of non-small cell lung cancers.

According to the National Cancer Institute, more than a third of all human cancers, including a high percentage of pancreas, lung and colon cancers are driven by mutations in a family of genes known as Ras.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

By producing the metabolite 2 - phosphoglycerate, PGAM1 regulates several different metabolic pathways, and the levels of this enzyme are abnormally elevated in various human cancers, including breast cancer, lung cancer, and prostate cancer.

Published in the Journal of Clinical Investigation, the study collected metabolic data directly from more than 120 human lung cancer patients.

B - raf gene mutations have known roles in the development of many human cancers including melanoma, lung and thyroid cancer.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

«We now know much more about metabolic reprogramming of cancerous tissues in human patients, particularly that the activation of pyruvate carboxylase is important to lung cancer cell growth and survival,» said Fan, UK professor of toxicology and faculty member of the Markey Cancer Center and CESB at the University of Kencancer cell growth and survival,» said Fan, UK professor of toxicology and faculty member of the Markey Cancer Center and CESB at the University of KenCancer Center and CESB at the University of Kentucky.

The machines handle the decaying element's radiation better than human miners and can tolerate the radon gas released by the ore; early Navajo miners of uranium in the U.S. — and their families exposed to residual radioactive dust and debris as well as contaminated water — developed lung cancer and other ailments by the 1970s and 1980s.

In a letter published in the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapy.

However, scientists at SFU, the University of British Columbia and the B.C. Cancer Agency have discovered that many non-coding RNAs are perturbed in cancerous human cells, including breast and lung, in a specific way.

These compounds cause cancer in laboratory animals, and studies of industrial workers strongly suggest they can cause lung cancer in humans too.

This week it emerged that the first human test of the controversial gene - editing technique CRISPR had taken place at West China Hospital in Chengdu, where oncologists used it to treat a man with an aggressive lung cancer.

Funding: NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Aging (NIA), National Center for Advancing Translational Sciences (NCATS), National Cancer Institute (NCI), and National Human Genome Research Institute (NHGRI); and many other funding entities (see reference paper for the full list).

At AACR, Blueprint Medicines (NASDAQ: BPMC) of Cambridge, MA, provided a first look at human data for its BLU - 667, which targets so - called RET fusions that can drive cancers of the lung, thyroid, and more.

Being both tumor - specific and widely expressed in human tumors, MAGE - A3 is an ideal cancer vaccine target and will be the focus of many clinical trials, including the largest clinical trial ever conducted in lung cancer, MAGRIT, launched by GlaxoSmithKline in 2007.

The National Heart, Lung and Blood Institute of the U.S. Department of Health and Human Services, the National Cancer Institute and Wyeth - Ayerst Research Laboratories funded the study, which involved researchers at nine institutions and 15 WHI clinical - study sites nationwide.

The 19 NIH institutes, centers and offices contributing to the Knockout Mouse Project are: the NIH Office of Strategic Coordination / Common Fund; NCRR; the National Eye Institute; NHGRI; the National Institute of Allergy and Infectious Diseases; the National Heart, Lung and Blood Institute; the National Institute on Aging; the National Institute of Alcohol Abuse and Alcoholism; the National Institute of Arthritis and Musculoskeletal and Skin Diseases; the Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIDCD; the National Institute of Dental and Craniofacial Research; the National Institute of Environmental Health Sciences; the National Institute of General Medical Sciences; the National Institute of Mental Health; the National Institute of Neurological Disorders and Stroke; the National Institute of Diabetes and Digestive and Kidney Diseases; the National Cancer Institute; and the Office of AIDS Research.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

Funding was provided by the Roddenberry Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Eye Institute, National Institute of Child Health and Human Development, National Institute of Mental Health, California Institute of Regenerative Medicine, Prostate Cancer Foundation, and the Leona M. & Harry B. Helmsley Charitable Trust.

Wang's team discovered that if human lung cancer cells in a lab dish in the presence of the receptor were treated with BCX, they migrated less than untreated ones.

Management of chemotherapy - related anaemia with low - dose recombinant human erythropoietin in patients with small cell lung cancer.

Previous studies have implicated FOXM1, which encodes a transcription factor protein capable of regulating the activity of many other genes, in many other human cancers, including liver, breast, lung, prostate, colon, and pancreatic cancers.

Mutation rates ten-fold higher than typical lung cancers in humans, though within three-fold of «hypermutator» tumors with mutations in DNA repair genes.

Miller said that the viral receptor gene, HYAL2, was located on a region of human chromosome 3 that is frequently altered in lung cancers.

In this fashion, they derive a signal from the tumor cells proportional to tumor mass which arises spontaneously in vivo in the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLC).

«We developed a new method of initiating lung cancer in mice, which has properties associated with human lung cancer, and used this model to identify the role of this enzyme in cancer proliferation.

LA JOLLA — Scientists at the Salk Institute have uncovered a molecule whose mutation leads to the aggressive growth of a common and deadly type of lung cancer in humans.

A high proportion (46 - 47 %) of C / A or G / T transversions, similar to the chemical - carcinogen signatures observed in human lung cancers.

Immunohistochemistry of paraffin - embedded human lung cancer tissue slide using 10379 -1-AP (SNRPD3 Antibody) at dilution of 1:50 (under 10x lens)

Miller's group, including postdoctoral fellow Dr. Sharath Rai, graduate student Vladimir Vigdorovich and collaborators at the National Cancer Institute, identified the human version of the viral receptor, a cell - surface protein called HYAL2 that has been implicated in lung cCancer Institute, identified the human version of the viral receptor, a cell - surface protein called HYAL2 that has been implicated in lung cancercancer.

I wanted to inactivate the gene BRAF (a kinase implicated in several human cancers) in A549 cells (a human lung cancer cell line), armed only with viruses obtained through Addgene's viral service and the methods sections of scientific articles (gasp).