Just as there is growing acceptance
of human obesity, there is growing acceptance of pet obesity and owners who take insufficient exercise themselves, often don't understand the importance of exercise for their pets.
These things, along with the gastrointestinal bacterial - triggered SOCS3 signaling are all implicated in the etiology
of human obesity.
People talk about animal models so this an animal model
of human obesity is the idea, but the problem with the model is you never know how they differ from the real thing and you never know about what assumptions you're working under.
There has been a growing body of literature using rodents as models
of human obesity, even though there are many confounding factors including species, strain, age of the animals, type of diet, level of fat, and type of control diet.
Obesity in these mice resembles several important clinical features
of human obesity such as weight gain and disturbance of metabolism, and this mouse model was ideal for unraveling any underlying biological mechanisms of pancreas cancer that are put in motion by obesity.
He explained that rimonabant, a drug which blocked endocannabinoid signaling at cannabinoid receptors, was on the market in Europe for the treatment
of human obesity.
Not exact matches
The Center for
Human Sleep Science found that getting less than seven hours
of sleep a nigh can be linked to medical ailments like cancer,
obesity and poor mental health.
This technique has been used, as Arnold reports, to trace the progress
of cancers, advance our understanding
of obesity and diabetes, and prove that brain cells continue to form through a
human being's lifetime.
On Planet Earth, two billion
humans suffer from
obesity and 800 million live on the edge
of starvation.
This allowed for the average soda size to balloon from 8 ounces to 20 ounces with little financial costs to manufacturers but great
human costs
of increased
obesity, diabetes, and chronic disease.
Such was the case when a dozen fourth and fifth graders posed a few hard - hitting questions to Health and
Human Services Secretary Kathleen Sebelius, Education Secretary Arne Duncan and Agriculture Secretary Tom Vilsack, who are all now part
of President Barack Obama's new federal task force to combat childhood
obesity.
In addition to reducing the chance
of obesity and improving mental health, gardening is relaxing and helps us engage with our
human roots.
11.10.2012 New Franchise for Military Veterans Tackles America's
Obesity Crisis Military veterans across the nation are becoming health and nutrition activists by starting a veteran - owned franchise with
HUMAN Healthy Vending — the nation's leading franchisor
of socially - responsible healthy vending machine businesses.
12.12.2011 World's First «Healthy Hot Food Vending Machine» Brings Healthy Meals to
Obesity - Stricken Food Deserts
HUMAN Healthy Vending launches world's first line
of vending machines to vend healthful hot foods, cold drinks and snacks simultaneously from the same machine.
For the infant,
human milk reduces the rates
of infection, allergies,
obesity, diabetes, leukemia, lymphoma, SIDS, and infant mortality2.
According to U.S. Department
of Health and
Human Services (HHS), breast milk can lead to a lower risk
of asthma, childhood leukemia,
obesity, ear infections, sudden infant death syndrome (SIDS) and respiratory infections.
According to the U.S. Department
of Health and
Human Services, eating a balanced diet, along with physical activity, will help you fight
obesity, reduce your risk
of chronic disease, and improve your overall health.
Human milk is low in protein compared to other milks and formula which appears to lead to decreased risk
of obesity.
Researchers on this project included lead author Ian M. Paul, Jennifer S. Savage and Michele E. Marini, Center for Childhood
Obesity Research, Penn State College
of Health and
Human Development and others.
I think that medicalized birth practices resulting in inter-generational deprivation
of our basic
human rights has been a major contributor epidemics
of diabetes and
obesity and mental health problems.
HUMAN is proud to donate 10 %
of its proceeds to charitable causes that fight childhood
obesity and malnutrition.
We know there is so much more to do in solving the problem
of childhood
obesity and in bringing healthy food to food deserts; so, we're just getting started,» said Andy,
HUMAN's managing partner.
HUMAN donates 10 %
of its proceeds to charities that fight the causes
of childhood
obesity and malnutrition, with a predominate recipient
of those funds being
HUMAN's non-profit charity arm,
HUMAN Everywhere.
Two are the Office
of Minority Health in the Department
of Health and
Human Services, and HBO, which produced the Weight
of the Nation
obesity documentary I discussed a few weeks ago.
Research published yesterday by the Medical Research Council,
Human Nutrition Research Centre and the Department
of Health found parents fail to respond to the warning signs
of childhood
obesity.
Low levels
of physical activity and inefficient sleep patterns intensify the effects
of genetic risk factors for
obesity, according to results
of a large - scale study presented at the American Society
of Human Genetics (ASHG) 2017 Annual Meeting in Orlando, Fla..
Similarly, jet lag in two
humans who had traveled from the United States to Israel changed the composition
of gut microbes, favoring the growth
of bacteria that have been linked to
obesity and metabolic disease.
«Our findings confirm in
humans what has been shown in animal models — that maternal
obesity has a more significant impact on the body composition
of boys than girls,» said Dr. Andres.
«Many people who have pets consider them as part
of the family and like
humans, dogs have a growing
obesity problem.
Obesity in animals, including
humans, is not dependent on the amount
of body weight, but on the amount
of body fat - specifically adipose tissue.
«We wanted to investigate whether
human adults had the ability to transform some white fat deposits into beige fat when they were exposed to cold,» said one
of the study's authors, Philip A. Kern, MD,
of the University
of Kentucky School
of Medicine in Lexington, KY. «Browning fat tissue would be an excellent defense against
obesity.
With global increase in
obesity and diet - related metabolic diseases, interest has intensified in ancestral or «Palaeolithic» diets, not least because — to a first order
of approximation —
human physiology should be optimized for the nutritional profiles we have experienced during our evolution.
«Our results indicate that the epigenetic modification we studied makes both mice and
humans more susceptible to
obesity and with increasing age increases their risk
of developing a fatty liver,» said Anne Kammel, first author
of the study.
«Whether an insulating effect
of obesity exists is
of significance both for
humans and for animal models
of obesity,» the research team wrote.
Until now, hundreds
of labs searching for a leptin defect or another gene that might cause
human obesity had come up empty - handed.
In
humans, too much fructose puts the liver at risk for conditions such as fatty liver disease, and raises the overall risk
of obesity and type 2 diabetes (SN: 10/5/13, p. 18).
Regulatory issues must be addressed before moving to
human studies, Davies said, but the findings published in the August issue
of the Journal
of Clinical Investigation suggest that it may be possible to manipulate the bacterial residents
of the gut — the gut microbiota — to treat
obesity and other chronic diseases.
Comparative anatomy and
human evolution experts from the University's School
of Medicine have been studying the correlation between meat consumption and
obesity rates in 170 countries.
This pattern
of weight gain and insulin resistance parallels the development
of obesity and Type 2 diabetes in
humans, Hinton said.
In the study, the scientists examined the
human serotonin receptor, which plays a role in learning, mood and sleep and is the target
of drugs that combat
obesity, depression and migraines.
«Knowing which microbes live in various ecological niches in healthy people allows us to better investigate what goes awry in diseases thought to have a microbial link, like Crohn's disease and
obesity,» says George Weinstock, associate director
of the Genome Institute at Washington University in St Louis and one
of the
Human Microbiome Project's principal investigators.
«Our results provide a large body
of evidence demonstrating that the harmine drug class can make
human beta cells proliferate at levels that may be relevant for diabetes treatment,» said senior study author Andrew Stewart, MD, Director
of the Diabetes,
Obesity and Metabolism Institute at the Icahn School
of Medicine.
«The BDNF gene has previously been linked to
obesity, and scientists have been working for several years to understand how changes in this particular gene may predispose people to
obesity,» said Jack A. Yanovski, M.D., Ph.D., one
of the study authors and an investigator at NIH's Eunice Kennedy Shriver National Institute
of Child Health and
Human Development (NICHD).
Given the importance
of this discovery, the researchers are confident they will obtain the funding needed to continue their work — says principle researcher Ahmad Agil — «and be able to achieve their final objective: to confirm these findings in
humans, by administering melatonin to help combat
obesity and diabetes.»
The results suggest that drugs capable
of targeting similar molecular pathways in
human fat cells could one day become major tools for fighting the growing worldwide epidemics
of obesity and type 2 diabetes, according to senior investigator Shingo Kajimura, PhD, an assistant professor
of cell and tissue biology in UCSF's School
of Dentistry.
The researchers are now examining whether CK2 - inhibitors can effectively reduce
obesity as well as prevent it, and whether they can be used alongside next - generation drugs that mimic the effects
of cold to trigger brown fat to burn energy in
humans.
From that perspective, it becomes clear that
humans are prone to
obesity because our bodies evolved in an environment
of scarcity, where consuming as much high - energy food as possible was a useful survival strategy.
The researchers note that while some genes involved in
obesity could already have been implicated in other aspects
of human health, others could be part
of pathways that are not yet understood.
By analyzing genetic samples for over half a million individuals as part
of the GIANT research project, which aims to identify genes that regulate
human body and size, researchers found more than 100 locations across the genome that play roles in various
obesity traits.
Even seemingly intractable problems such as the antibiotic crisis and the
obesity epidemic could be resolved by treating
human health and society as an integral part
of an ecosystem.