Sentences with phrase «of human oocytes»

While many important developments impacted the field, two that garnered significant public, political and scientific attention in 2016 were the proliferation of clinics using unproven stem cell «therapies,» and the steps forward in therapeutic modification of human oocytes (unfertilized eggs) through a process called mitochondrial replacement therapy (MRT).

But few labs had a source of human oocytes with which to attempt the experiment.

The results come from the first year of the Human Oocyte Preservation Experience (HOPE) Registry, which is analysing the results of thawed - egg IVF over five years.

Not exact matches

As with humans, he says, the oocytes of C. elegans also show an increase in chromosome abnormalities with aging.

Mindful of public sensitivities, Daley opted to pursue experiments using what he considers the least controversial human materials to create new nonpresidential stem cell lines — poor quality embryos and oocytes that, in his words, «otherwise would have been disposed of as medical waste.»

To do this, they used a nanotemplate of known stoichiometry (the human Glycine receptor expressed in Xenopus oocytes) and studied several fluorescent proteins to see the percentage of proteins that was photoactivated.

«The use of nonhuman oocytes for SCNT is currently the only ethically justifiable option given the large numbers of eggs required to derive cloned human stem cell lines,» he said.

Outline title: «First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh syndrome» by J. Zhang et al. published in outline form by the American Society of Reproductive Medicine's Fertility and Sterility journal website.

Appearance of an oocyte activation - related substance during spermatogenesis in mice and humans.

Oocyte activation ability correlates with head flatness and presence of perinuclear theca substance in human and mouse sperm.

Scientists publishing in the journal Cell Stem Cell have reported the production of functional human oocytes from discarded genetic material, a process which they suggest could one day assist in fertility treatment or mitochondrial replacement therapy.

As outlined below, we used a microfluidic quantitative PCR (qPCR) system to elucidate the gene expression profiles of individual human oocytes and small numbers of cumulus cells using a combination of a large number of samples and targets [12], and then extended our studies via the use of parthenogenesis, in conjunction with gene expression profiling, as a functional assay of cytoplasmic maturation of oocytes.

Ms. Roxland concurrently served as the Special Advisor to the Commissioner of Health on Stem Cell Research Ethics, where she spearheaded creation of state - wide rules on embryonic stem cell protocols, human - animal chimera research, compensation of women who donate their oocytes to stem cell research, informed consent processes, re-contact for return of research results and incidental findings, and downstream uses of biological samples.

Both animal and human studies have demonstrated the important roles of neurotrophins (BDNF, NTF3 and NTF4) in oocyte maturation mediated by their receptors (NTRK1 — 3 and NGFRAP1)[20], [25].

Since the first report of in vitro human oocyte maturation in 1969 [3], several reports have documented blastocyst (BL) development or live birth achieved from oocytes matured in vitro [1], [4], [5].

Immature human oocytes were matured in vitro via supplementation with ovarian paracrine / autocrine factors that were selected based on expression of ligands in the cumulus cells and their corresponding receptors in oocytes.

As a reminder, the lifetime supply of all oocytes of a human female is produced before puberty.