Sentences with phrase «of human pathology»

The goal of this Unit is based on the simple, but fundamental, concept that an understanding of normal developmental regulation should provide us with a better understanding of the basis of human pathology.

Biomedcode's unique animal models of human TNF - depended arthritis have offered the first proof of concept for the central role of TNF in the development of human pathology.

From a public health perspective, aging is also the critical risk factor for a variety of human pathologies, including neurodegenerative diseases, many forms of cancer and metabolic disease.

Not exact matches

The pathologies of speech, hearing, and sight demonstrate the profound dependence of all of the higher human functions upon bodily structures.

Examines the pathology of normalcy in our society and the creation of a society in which human needs will be fulfilled.

It also follows from Legutko's view that liberal orders like the EU recreate the pathologies of communism, albeit with a human mask.

Assagioli has an appreciation for the way in which the intensive study of pathology by psychoanalysis and depth psychology has enlarged and deepened our understanding of the human psyche.

The growth contributions of the traditional therapies are, for the most part, concentrated in two areas — their illumination of the depths and complexity of human personality, and their insights about the nature and dynamics of deeply blocked growth (pathology).

But it does throw some light upon the dark side of the human story if we see human cruelties and destructiveness as corruptions of the power to love, and thus as belonging not to the norm of human nature but to its pathology.

There are great differences among these three spokes - persons for social possibility and pathology, but they all focus on the fact that societies have ways in which to articulate and distort certain kinds of truth that make human life possible Or problematic.

Jung sought an explanation for the human psyche that went beyond what he once called «the curse of pathology.»

First of all, it implies some superficial beliefs about the place of sexuality in human experience (we might regard these as being in the antechamber of the temple of sacred sexuality proper): the belief that sexuality is a key, perhaps even the key, component of the quality of being human (in this, of course, lies the pervasive heritage of Freud); the belief that modern Western culture, and especially American culture, has unduly suppressed sexuality (this is the anti-Puritan aspect of the proposition), and, that, as a result, not only are we sexually frustrated (and that frustration carries all sorts of physical and psychological pathologies in its wake), but our entire relation to our own bodies as well as the bodies of others has become distorted.

«Pathologies of power: rethinking health and human rights,» American Journal of Public Health 89 (10): 1486 - 1496.

«Norovirus is one of the deadliest human pathogens that we know the least about,» said first author Craig B. Wilen, MD, PhD, an instructor in pathology and immunology.

«We feel it's critical that the scientific community consider the potential hazards of all off - target mutations caused by CRISPR, including single nucleotide mutations and mutations in non-coding regions of the genome,» says co-author Stephen Tsang, MD, PhD, the Laszlo T. Bito Associate Professor of Ophthalmology and associate professor of pathology and cell biology at Columbia University Medical Center, and in Columbia's Institute of Genomic Medicine and the Institute of Human Nutrition.

«Before this study, it was not known if it is possible to produce sufficient numbers of these cells and successfully use them to remuscularize damaged hearts in a large animal whose heart size and physiology is similar to that of the human heart,» said Dr. Charles Murry, UW professor of pathology and bioengineering, who led the research team that conducted the experiment.

«Every human carries trillions of bacteria in their gut (gut microbiome) and recent advances in research indicate that these tiny passengers play an important role in our overall health maintenance,» says Ashutosh Mangalam, PhD, assistant professor of pathology at the University of Iowa Carver College of Medicine.

This evidence indicates that LB1 is not a modern human with an undiagnosed pathology or growth defect; rather, it represents a species descended from a hominin ancestor that branched off before the origin of the clade that includes modern humans, Neandertals, and their last common ancestor.

«Lots of ideas and efforts have been made to use NSAIDs to treat human pathologies, including colorectal cancer and other diseases,» Miller said.

The physician - scientist may study the same properties of the same molecule but for a different reason: because he or she believes that those studies will provide information on the fundamental pathology of a disease or insight into human biology that will provide a better understanding of healthy versus diseased states.

«The findings underline the therapeutic potential of this endogenous anti-inflammatory factor, Del - 1, in further human pathologies where the levels of Del - 1 are reduced,» Chavakis said.

So you can put all this together and say it's reasonable that some of this is really driving pathologies in humans.

Jasper says age - related loss of metabolic balance is a risk factor for many human pathologies.

New findings published in Biological Psychiatry brings us closer to understanding the pathology of autism, and the point at which it begins to take shape in the human brain.

Knowledge of these mechanisms in songbird species with different social and mating systems may in turn elucidate social and sexual pathologies in humans.

The study, led by Dr. Maximilian Muenke of the National Human Genome Research Institute in Bethesda, Maryland, brings scientists closer to understanding how ADGRL3 contributes to risk by providing functional evidence that implicates a transcription factor in the pathology of the disorder.

«We think that for the first time, we have a mouse model of anorexia that closely resembles the conditions leading up to the disease in humans,» said study leader Lori Zeltser, PhD, associate professor of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.

Researchers from Kent State University's College of Arts and Sciences, along with colleagues from the George Washington University, Yerkes National Primate Research Center, Georgia State University, Barrow Neurological Institute and the Icahn School of Medicine at Mount Sinai, found that the brains of aged chimpanzees, our closest living relatives, show pathology similar to the human Alzheimer's disease brain.

«Very few studies have investigated Alzheimer's disease pathology in chimpanzees, the species closest in phylogeny and most genetically related to humans,» said senior author Mary Ann Raghanti, Ph.D., associate professor and interim chair of anthropology at Kent State.

«The presence of amyloid and tau pathology in aged chimpanzees indicates these Alzheimer's disease lesions are not specific to the human brain as generally believed,» Hof continued.

Kent State University researchers analyzed the brains of aged chimpanzees to show pathology similar to the human Alzheimer's disease brain.

For centuries people have painted cities as unnatural human conglomerations, blighted by pathologies such as public health crises, aggression and exorbitant costs of living.

«Peripheral neuropathy is a major and largely untreated cause of human suffering,» said first author Nigel Calcutt, PhD, professor of pathology at UC San Diego School of Medicine.

The next step, says Makoto Kuro - o, an assistant professor of pathology at the University of Texas Southwestern Medical Center, is to study Klotho in humans.

The authors also found abnormalities in the subthalamic nucleus occur earlier than in other brain regions, and that subthalamic nucleus nerve cells progressively degenerate as the mice age, mirroring the human pathology of Huntington's disease.

They grow as extracellular parasites inside phlebotomine sand flies that transmit Leishmania to variety of vertebrates, such as rodents, dogs, and humans, where they grow inside immune cells, notably macrophages, causing severe pathologies that may lead to death.

Researchers Bob Hider and S. Singh from the Department of Pharmacy at King's College, London describe the effects and novel chemical treatments of pathology caused by an imbalance of iron in the human body.

Results of previous studies in mice of bexarotene's effect on AD have been mixed, and none of those studies were done in mice that carry a human APOE gene and also develop progressive, AD - like pathology.

iPS cells enable to enlarge applications for modeling numerous human pathologies, reproducing the dysfunction processes of damaged tissue, and developing targeted medicine.

«Very few studies have investigated Alzheimer's disease pathology in chimpanzees, the species closest in phylogeny and most genetically related to humans,» said senior author Dr. Mary Ann Raghanti, associate professor and interim chair of anthropology at Kent State.

The brains of aged chimpanzees, our closest living relatives, show pathology similar to the human Alzheimer's disease (AD) brain, according to a new, multi-institution research study.

«It's probably the single most common gene fusion in human cancer,» said study co-leader Antonio Iavarone, MD, professor of neurology and of pathology and cell biology (in the Institute for Cancer Genetics) at CUMC.

The rest of the complex anatomical changes that are observable in human evolution are subsumed under one heading: pathology.

The setting in Honolulu captured my conflicted mood perfectly — human pathology inside the convention center and great natural beauty outside of it.

Among large animals, the dog is an extraordinary species with an extremely high quantity of human - like pathologies, correlated with the large variety of races.

Human Embryonic Stem (hES) cells derived from Preimplantation Genetic Diagnosed (PGD)- embryos offer a new alternative source of cellular model as they can be largely expanded, differentiated in several cell types and harbors «naturally» the causative mutation of the pathology.

We have found that expression of C3 in normal mouse eyes leads to pathology similar to AMD in humans, including the creation of anaphylatoxins and the MAC.

Monogenic diseases are often lacking of physiological human cellular models dedicated to the study of the molecular mechanism implicated in the development of the pathology.

The unit study macromolecules that are central in basic processes of cellular life, as well as for specific human pathologies.

We have combined microbiology and immunology with functional genetics and have developed critical mouse models of chronic bacterial infection that reproduce the advanced - stage human pulmonary pathology.