Sentences with phrase «of human somatic cells»

In the following year, the direct reprogramming of human somatic cells was accomplished [2], [3].

The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) offers tremendous potential for cell therapy, basic research, disease modeling, and drug development.

The telomerase deficiency of human somatic cells reduces the risk of cancer development, as telomerase fuels uncontrolled cancer cell growth.

Not exact matches

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

In May 2013, Mitalipov was the first scientist in the world to demonstrate the successful use of somatic cell nuclear transfer, or SCNT, to produce human embryonic stem cells from an individual's skin cell.

L1 - associated genomic regions are deleted in somatic cells of the healthy human brain.

Opponents said that the measure should have banned somatic cell nuclear transfer; it criminalized only the «implantation» of an embryo into a woman to create a human clone.

To sum up, we have seen that somatic cells of various origins, including human, can be lineage reprogrammed into induced neurons.

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

Our definition is similar to the European Medicines Agency (EMA) definition of Advanced Therapy Medicinal Product (ATMP): «Medicinal product for human use that is a gene therapy medicinal product, a somatic cell therapy medicinal product or tissue engineered product» (EMA ATMP Reg.

Comparisons of genetically matched human pluripotent stem cells reveals that somatic cell nuclear transfer is the ideal means of generating cells for replacement therapy

Disease - specific human pluripotent stem cells, from embryonic origin or derived from reprogramming somatic cells, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

seek to identify the mutational processes underlying mutational signatures found in cancers, characterise the mutational processes operating in normal cells, use phylogenetic analyses of somatic mutations in humans to explore cellular lineages during embryonic development

Pluripotent stem cellderived somatic stem cells as tool to study the role of microRNAs in early human neural development

He was also a Fulbright Scholar, and was part of the team that cloned the world's first human embryo, as well as the first to successfully generate stem cells from adults using somatic - cell nuclear transfer (therapeutic cloning).

A proprietary bioinformatics tool for the detection of aging biomarkers in DNA samples from somatic cells of human and mouse;

WIKIMEDIA, CSIROAfter human somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs), the resulting cells retain both genetic and epigenetic indicators of the age of the person who donated the somatic - cell progenitors, scientists have found.

In light of the observation that iPS cell derivation takes place under the same culture conditions used for ES cells [20], we hypothesized that these human feeder cells could offer a stable tool for defining molecular hallmarks during conversion of differentiated somatic cells to the pluripotent state.

Reprogramming human somatic cells to pluripotency represents a valuable resource for the development of in vitro based models for human disease and holds tremendous potential for deriving patient - specific pluripotent stem cells.

In the several years since those first reports, new advances in the derivation of hiPSCs from various tissue sources (including those from human patients) and using diverse reprogramming techniques, and in their use as a pluripotent cell source in the induced differentiation of a wide array of somatic cell types, have appeared with almost startling rapidity.

The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity.

The goal of our laboratory is to generate pluripotent stem cells from human somatic cells.

The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential uses in cell therapy.

In contrast to germline variants, somatic variants are not propagated to the whole individual but to a subpopulation of cells in the body, with the final consequence that adult human tissues are a mosaic of genetically different cells.

Human pluripotent stem cells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell tHuman pluripotent stem cells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell tcells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell thuman Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell tCells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell tcells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell thuman Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell tCells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell types.

Most human somatic cells can undergo only a limited number of population doublings in vitro.

However, this is inefficient and has a low throughput method so I aim to use our growing knowledge of epigenetics to devise strategies for «reprogramming» human somatic cells towards a stem cell like phenotype.

Telomere maintenance has been proposed to play a central role in human aging by limiting the replicative potential of somatic cell populations and... >> MORE