Sentences with phrase «of human tissue samples»

THE CREATION of a single Government - funded body to oversee the retention of human tissue samples has moved a step closer...

Not exact matches

The team also tested human milk samples from subjects with mastitis, an infection of the breast tissue that causes pain and inflammation.

There are only a few instances of the polymer being assayed in the milk of women with implants; the concentrations are not elevated over control samples.20 There is no evidence at the present time that this polymer is directly toxic to human tissues; however, concern also exists that toxicity may be mediated through an immunologic mechanism.

More work has to be done on humans as many of the results showed up in mice samples, however in studying the human brains of women who had AD scientists found significantly less male fetal tissue in their brains as in the same of women who did not have AD.

Research into the biology of human lactation has been seriously impeded by the impracticality and ethical concerns of obtaining systematic samples of mammary tissue from lactating woman.

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

West Nile virus and Powassan virus also replicated, or multiplied, more efficiently than the alphaviruses in lab samples of human placental tissue.

Larger biomarker signatures can be detected with technology from CDI Laboratories, which offers microarrays of functional human proteins (over 20,000 on a single array) to test the antibodies present in human liquid biopsy samples, such as blood, serum, plasma, CSF, or tissue lysates.

In cancer research, our goal is to be able to start with a sample of human tissue, extract many cells of interest, and perform genetic analysis upon each of them separately.

The biobank of MedUni Vienna and Vienna General Hospital is a central service facility dedicated to the storage of human tissue, cell material and body fluids for more in - depth diagnosis, academic research projects and clinical tests, as well as working - up samples by way of a medical service.

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

Senior author Madhav Dhodapkar, M.D., the Arthur H. and Isabel Bunker Professor of Medicine and Immunobiology, and chief of Hematology, said the study, using tissue and blood samples from humans and mice, shows that chronic stimulation of the immune system by lipids made in the context of inflammation underlies the origins of at least a third of all myeloma cases.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

By using a range of tissue stains, they were able to assess levels of oestrogen receptor (ER), progesterone receptor (PR) and HER2 — human epidermal growth factor — in order to divide the samples into four subtypes.

The interdisciplinary project team is made up of eco - and human toxicologists, physicists, chemists and biologists, and they have just managed to take their first major step forward in achieving their goal: they have developed a method for testing a variety of environmental samples such as river water, animal tissue, or human urine and blood that can detect nanomaterials at a concentration level of nanogram per liter (ppb — parts per billion).

These triple - mutant H7 hemagglutinins also successfully latched onto cells in samples of human trachea tissue.

Iwasaki and colleagues next added type I interferon to samples of human placental tissue in dishes.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

Dr. Wang plans to continue studying the effects of TNF and IL - 17 on melanocytes, and would like to expand the research to 3D skin models — fabricated samples of tissue in vitro that behave like human skin — that would give a better visual of how the melanin production process is being disrupted by these two cytokines during skin inflammation or wound healing.

To streamline this process, Uhlén's team has created standardized arrays containing microscopic samples from 48 kinds of normal human tissue and 20 types of tumors.

The molecular fingerprint obtained by the MasSpec Pen from an uncharacterized tissue sample is instantaneously evaluated by software, called a statistical classifier, trained on a database of molecular fingerprints that Eberlin and her colleagues gathered from 253 human tissue samples.

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

The Ogretmen laboratory screened previously reported microarray data sets of several human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and renal cell carcinoma) and showed that, in these samples, only the levels of CerS4 were significantly decreased.

The scientist tested their set - up using frozen human skin cells, segments of pig heart tissue, and sections of pig arteries in volumes almost 20 times larger than previously attempted samples.

«We can apply this method to any type of clinical sample and all types of human tissues, including normal and cancerous tissues,» said co-lead author Yongxin Zhao, PhD, of MIT's Media Lab.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

Historically, animal models — from fruit flies to mice — have been the go - to technique to study the biological consequences of aging, especially in tissues that can't be easily sampled from living humans, like the brain.

«Body on a chip» could improve drug evaluation: Human tissue samples linked by microfluidic channels replicate interactions of multiple organs..»

To discover how HIV causes AIDS, Gladstone scientists studied HIV - infected samples of human tonsil and spleen tissue.

Finally, the researchers analyzed samples of human brain tissue from patients with Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and multiple sclerosis.

The use of muscle tissue in post-mortem studies is a novel approach which presents several advantages: first, muscle tissue is the most abundant tissue of the human body and can therefore be sampled easily.

The study of human astrocytes has faced issues related to access (samples of living tissue must be obtained from brain cancer or epilepsy surgeries or fetal tissue) and purification (breaking apart astrocytes away from other cells often killed them and many experiments ended in failure).

They also demonstrated that the probe could acquire separate coherent anti-stokes Raman scattering, second harmonic generation and two - photon excited autofluorescence images of healthy human skin tissue samples with a resolution of 2048 by 2048 pixels for a scanned area of 300 by 300 microns.

Livia Eberlin at the University of Texas, whose team created the device, tested it on 253 human tissue samples (Science Translational Medicine, doi.org/cctx).

With the help of an Egyptology professor, he obtained soft - tissue samples from several Egyptian mummies and, in 1984, coaxed scraps of human genetic material from them.

In Peru, the National Institute of Health's urine samples reflect elemental mercury — mainly vapor inhaled within the past several days — but not methylmercury accumulated in human tissue, which shows up in blood or scalp hair.

The researchers also analyzed samples of human neural tissue from embryos that had been stored by a hospital pathologist..

The researchers analyzed the concentrations of 5,713 different lipids, or fat molecules and their derivatives, present in samples of brain, kidney and muscle tissues taken from humans, chimpanzees, macaques and mice.

Subcutaneous adipose tissue samples were aspirated from the subcutaneous abdominal region of human subjects whose BMIs ranged from 19.4 to 60.1 kg / m2.

The next step will be to explore the effects of lipoxin A4 in samples of human fat tissue, said Borgeson, who has already started this work as a guest researcher at the Sahlgrenska Academy Hospital in Sweden.

By studying these conditions in rats and other animals, Roberts and his colleagues say, researchers can avoid the ethical conundrum involved in forcing active children to refrain from exercise, imposing biopsies and other tissue sampling techniques, or other parts of research that are possible in animals but not in humans.

For each assay, 200 μl of sample (taken from the Optisol solution bathing the human and rabbit corneal endothelial tissues) was added to microplates coated with TGF - β receptor.

Usually, because of the inaccessibility of brain tissue in living humans, epigenetic studies are carried out using blood samples.

ONE - PARENT SAMPLE SET PARENTAL GUIDANCE RULES: Maternally methylated (red dots) and paternally methylated (blue dots) regions across the human autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are exprehuman autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expreHuman METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expressed.

Building on 30 years of research, this achievement outlines three fundamental steps that successfully took ovarian tissue samples and nurtured them into human eggs to a point of full maturity.

Acquire tissue samples and clinical information from as many cases of human prion disease occurring in the United States as possible in order to help monitor the possible occurrence of variant CJD (vCJD) in the USA.

Human spinal cord tissues were obtained from two nine week old, de-identified abortus samples collected in the course of medically prescribed procedures using the Safe - Harbor Method.

Western blot analysis of antibody specificity has been done using a routine sample setup composed of IgG / HSA - depleted human plasma and protein lysates from a limited number of human tissues and cell lines.

Our proprietary discovery platform enables the identification of disease - specific hydroxymethylated (5hmC) DNA from blood and tissue samples — enhancing human health through more accurate and earlier diagnosis, improved patient stratification and the development of liquid biopsy - based tests.

The study looked at transcriptional profiles of 247 tissue samples from six humans, five chimps, and five macaques.