Sentences with phrase «of humoral»

Ontogeny of humoral immunity in northern elephant seal (Mirounga angustirostris) neonates.

Dr Jean W Dodds, writing in US Dog World, March, 1995, (16) states: «Immune — suppressant viruses of the retrovirus and parvovirus classes have recently been implicated as causes of bone marrow failure, immune - mediated blood diseases, haematologic malignancies (lymphoma and leukemia), dysregulation of humoral and cell - mediated immunity, organ failure (liver, kidney) and autoimmune endocrine disorders — especially of the thyroid gland (thyroiditis), adrenal gland (Addison's disease) and pancreas (diabetes).

Lack of humoral immunity may contribute to the slower rate of destruction of β - cells in people with chronic pancreatitis compared with those with type 1 diabetes (97).

The FDA now requires that the chelator EDTA include calcium salts to prevent the death of humoral immunity.7

Salty flavor is hot, heavy and wet in quality, and helps to reduce and balance vāta, the component of the humoral theory in Āyurveda that is most closely associated with function of the nervous system.

Together these approaches allowed us to highlight the focus of humoral responses and hypothesise new modes of pathogen immune evasion.

Immunogenicity and efficacy studies in pig (influenza) and sheep (RSV) with a focus on skin vaccination and extended monitoring of humoral and cellular immune responses in the blood and lung.

In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADE.

The exact composition of germline V gene sequences in an individual has been difficult to determine due to the highly repetitive nature of the genomic sequences encoding these segments, thus limiting our understanding of humoral immune responses.

Antigen - Specific Suppression of Humoral Immunity by Anergic Ars / A1 B Cells % U http://www.jimmunol.org/content/early/2012/09/23/jimmunol.1201818.short.

Antigen - Specific Suppression of Humoral Immunity by Anergic Ars / A1 B Cells.

A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell - mediated immunity, leukopenia, and low or absent antibody levels.

We produce live and inactivated viruses in our BSL2 and BSL3 facilities, and perform immunogenicity and efficacy studies in pigs (influenza) and sheep (RSV) with a focus on skin vaccination and extended monitoring of humoral and cellular immune responses in the blood and lung.

(**) C. Hammer et al.: Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses.

«The key was the use of the humoral factor LIF.

The researchers then examined various combinations of humoral factors to determine the optimal culture conditions.

Not exact matches

In the higher organisms, including man, a complex set of neural and humoral regulatory mechanisms preserve the stability of the metabolic processes within very narrow limits, despite substantial changes in the external environment.

The South Asian culture has a strong belief in the maintenance of the body's «hot - cold» (humoral) equilibrium to sustain good health.

These findings update results presented at December's Annual Meeting of the American Society of Hematology, with additional analysis examining the speed of patients» humoral immunity recovery following therapy.

During his postdoctoral training at the California Institute of Technology, he developed Vectored ImmunoProphylaxis (VIP) as a means of engineering humoral immunity, leading to successful demonstration of this approach as a prophylaxis against HIV as well as influenza.

Michael Pfreundschuh and colleagues Ugur Sahin and Ozlem Türeci at the University of Saarland develop SEREX (SErological analysis of Recombinant cDNA Expression), providing a powerful method to analyze the humoral immune response to intracellular cancer antigens and ushering in the third phase of cancer serology, bringing with it the prospect of providing a comprehensive view of the immune recognition of human cancer.

UNISI will investigate whether the magnitude of antigen - specific cellular responses generated after priming can predict the secondary humoral response.

cellular immunity - protection provided by the cells of the body's immune system (as opposed to humoral immunity).

We will evaluate the immunogenicity of vaccine candidates (provided by user) administered by systemic, transdermal or mucosal routes and will monitor humoral responses and cellular responses.

Jäger E, Stockert E, Zidianakis Z, Chen YT, Karbach J, Jäger D, Arand M, Ritter G, Old LJ, Knuth A. Humoral immune responses of cancer patients against «Cancer - Testis» antigen NY - ESO - 1: correlation with clinical events.

Richard Pfeiffer demonstrates the rapid killing of cholera bacteria in the cell - free serum of immunized guinea pigs («Pfeiffer's phenomenon»), providing further evidence for the humoral theory of immunity.

The late - boost study, led by scientists from AFRIMS and the Thai Ministry of Health, found that vaccine boosts containing AIDSVAX B / E generated increased, but short - lived, humoral and CD4 + T - cell responses that did not rise further after subsequent boosting.

The CD4 subset is capable of directing B cell responses and humoral immunity, and can modulate the actions of many other cell types including CD8 T cells, dendritic cells, macrophages, eosinophils, and basophils.

However, until an AMA1 malaria vaccine demonstrates clinical efficacy against genetically diverse natural parasites, the relevance of growth inhibition assays and other humoral and cellular immunogenicity endpoints for clinical development decisions will remain a matter of reasoned conjecture.

The fat body senses the concentration of intracellular amino acids through the activity of the Target of Rapamycin (TOR) signaling pathway, which in turn regulates the synthesis and secretion of an undescribed humoral factor (s), called the fat - body — derived signal.

The fat body senses intracellular amino acids through Target of Rapamycin (TOR) signaling, and produces an unidentified humoral factor (s) to regulate insulin - like peptide (ILP) synthesis and / or secretion in the insulin - producing cells.

You will be responsible for the development of immune assays to facilitate the assessment of responses post nairovirus exposure, including assessment of both cellular and humoral immunity.

Although much is known regarding the specificity and efficacy of antibody responses, our knowledge of the function, phenotype, and specificity of the antigen - specific B cells that are responsible for antibody production, as well as for long - term humoral memory, is inadequate.

This led to the establishment of international collaborations aimed at preclinical identification, development and selection of HIV vaccine candidates, such as NeutNet, a worldwide consortium dedicated to the standardisation of HIV neutralisation assays, and the Humoral Immunity Platform of EUROPRISE.

The SPG cell layer, which is adjacent to the neurons of the brain, forms septate junctions, which function as a barrier to separate the humoral space and the brain, analogously to the mammalian tight junctions formed between endothelial cells.

Working with Inovio Pharmaceuticals, Duke University, Emory University, University of Massachusetts and the National Institutes of Health, the group aims to build on the success of previous generations of DNA vaccines in order to induce strong cellular and humoral responses.

In Stiff Person Syndrome, which is a rare autoimmune disease in the central nervous system with autoantibodies targeting glutamic acid decarboxylase (GAD65), the humoral autoimmune response was shown to consist of a Rituximab - sensitive part rapidly cleared after treatment, and a Rituximab - resistant part from long - lived and persistent plasma cells acting as a reservoir for secretion of autoantibodies.

We are currently investigating the role of various T - cell costimulatory pathways in regulating the humoral and cellular responses to and between DENV and ZIKV, and are defining the particular pathways that should be targeted to maximize safety and efficacy of vaccines.

Odunsi K, Qian F, Matsuzaki J, Mhawech - Fauceglia P, Andrews C, Hoffman EW, Pan L. Ritter G, Villella J, Thomas B, Rodabaugh K, Lele S, Shrikant P, Old LJ, Gnjatic S. (2007) Vaccination with an NY - ESO - 1 peptide of HLA class I / II specificities induces integrated humoral and T cell responses in ovarian cancer.

For example, previous studies reported that only 23 % of immune sera examined contained specific serum IgG antibodies against PFA0135w, suggesting that this protein does not normally elicit strong humoral responses [59].

Our data indicate that 3 of 16 patients mounted a vaccine - specific humoral immune response.

In that study, only 1 of 12 patients had an anti-Id specific humoral response.

In addition to myself and Sally Fallon, our petition was signed by three worldclass scientists: Kilmer S. McCully, MD, father of the homocysteine theory of heart disease, winner of the 1998 Linus Pauling Award and author of The Homocysteine Revolution and The Heart Revolution; Mary G. Enig, PhD, the world renowned biochemist and nutritionist who exposed the dangers of trans fats in the food supply back in the 1970s, vice president of WAPF, author of Know Your Fats and co-author of Eat Fat Lose Fat and Nourishing Traditions; and Galen D. Knight, PhD, a biochemist who has carried out pioneering research on the role of vitalethine in humoral immunity and cancer development.

Kunze R., Ransberger K., et at: Humoral immunomodulatory capasity of proteases in immune complex decomposition and formation.

Nonetheless, the inhibitory substance involved in this humoral mechanism that may be linked to colonic fermentation is still putative, even though several observations led us to consider a possible involvement of incretins such as polypeptide YY and glucagon - like peptides (25 — 27).

Recent research has identified that adenosine acts as a homeostatic regulator of sleep and to be a link between the humoral and neural mechanisms of sleep - wake regulation.

Chelation therapy can lead to hypocalcemia, a severe lowering of blood calcium levels with disastrous effects upon humoral immunity.6 We also have reports of comas and blood cell rupturing due to chelation therapy.

We are investigating the influence of physical, neural and humoral factors on the generation of lymph flow with particular emphasis on the mechanisms by which these factors alter the active lymph pump.

Production of these antibodies against the BBB and other neural cell antigens from a cell - mediated and humoral immune response may indicate a pathological alteration of the protective brain barrier.

In fact the presence of good humoral antibody levels blocks the anamnestic response to vaccine boosters just as maternal antibody blocks the response in some young animals.»