Sentences with phrase «of hyperglycaemia»

Within pancreatic Î ² cells, excessive lipid deposition causes the metabolic inhibition of postprandial insulin secretion which, above an individual threshold, will herald the onset of hyperglycaemia.

Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat.

Research is underway to evaluate these closed - loop systems in the very young, in pregnant women with type 1 diabetes, and in hospital in - patients who are suffering episodes of hyperglycaemia.»

With regard to microvascular complications, the authors say that «a refocus towards intensive management of hyperglycaemia at diagnosis, particularly in younger people, may be warranted if the long - term risk of microvascular complications is to be minimised.

Not exact matches

It is useful to provide greater insight into glucose levels throughout the day, supply trend information, determine benefits (or otherwise) of medication changes and may help identify and prevent unwanted periods of hypo and hyperglycaemia (2,3)..

The most common, more severe adverse event (grade 3) was hyperglycaemia, which was observed in 14 % of patients.

One of the greatest health concerns in developed countries is the increase in obesity, diabetes, and metabolic syndrome, which is a combination of high blood pressure (hypertension), blood sugar (hyperglycaemia), and cholesterol (dyslipidemia) along with increased belly fat.

A cross-sectional study of glucose regulation in young adults with very low birth weight: impact of male gender on hyperglycaemia

Using cut - offs recommended by guidelines, we defined obesity and overweight using body mass index (BMI), and metabolic dysfunction («unhealthy») as ≥ 3 of elevated blood pressure, hypertriglyceridaemia, low HDL - cholesterol, hyperglycaemia, and elevated waist circumference.

Within diabetic populations, hyperglycaemia is considered the hallmark diagnostic marker of metabolic abnormality and a major contributor to T2DM associated macro - and micro - vascular complications.61 One study by Ash et al 36 saw 51 overweight / obese male subjects with T2DM assigned to one of three groups; (i) IER (four days 50 % ER, three days ad libitum intake / week), (ii) CER (30 % ER / day, all meals provided) and (iii) CER (30 % ER / day, food self - selected by the participant).

Conversely, within non-diabetic populations, periods of IER (75 - 85 % ER on restricted days) do not typically affect fasting glucose levels 37, 41, 45, 48 or HbA1c 41, 48; results of which can often be replicated by short term CER studies.62 - 65These findings are unsurprising given that frank hyperglycaemia within the T2DM diagnostic range is effectively a late - stage manifestation of IR, which along with compensatory increases insulin secretion, can precede the onset of T2DM by many years.66, 67 Findings from one large scale prospective cohort study, Whitehall II, reveal a sharp increase in the trajectory towards fasting hyperglycaemia which is only detectable three years prior to diagnosis with T2DM.67 Consequently, it can be argued that changes in circulating insulin concentrations, fasting (hepatic) insulin sensitivity and glucose uptake / clearance are more sensitive markers of deteriorating glucose control than fasting glycaemia in non - diabetics.68 - 70

In the past two decades several medical treatments that exert their effects despite hyperglycaemia have been derived from the experimental pathogenetic concepts of diabetic neuropathy.

Long - term mortality after community - acquired pneumonia — impacts of diabetes and newly discovered hyperglycaemia: a prospective, observational cohort study

Chronic hyperglycaemia, the main characteristic of badly managed DM, is associated with a wide range of acute and chronic complications that can affect all the body's organs and systems, including the gingival and periodontal tissues.